G-quadruplexes: from guanine gels to chemotherapeutics.

[1]  P. Hainaut,et al.  G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms. , 2011, Carcinogenesis.

[2]  S. Cacchione,et al.  Self-organization of G-quadruplex structures in the hTERT core promoter stabilized by polyaminic side chain perylene derivatives. , 2010, Biophysical chemistry.

[3]  S. Basu,et al.  An RNA G-quadruplex is essential for cap-independent translation initiation in human VEGF IRES. , 2010, Journal of the American Chemical Society.

[4]  A. Lane,et al.  Hydration is a major determinant of the G-quadruplex stability and conformation of the human telomere 3' sequence of d(AG3(TTAG3)3). , 2010, Journal of the American Chemical Society.

[5]  Yoon-Joo Shin,et al.  Evidence of the formation of G-quadruplex structures in the promoter region of the human vascular endothelial growth factor gene , 2010, Nucleic acids research.

[6]  S. Balasubramanian,et al.  The BCL-2 5' untranslated region contains an RNA G-quadruplex-forming motif that modulates protein expression. , 2010, Biochemistry.

[7]  Kah Wai Lim,et al.  Coexistence of two distinct G-quadruplex conformations in the hTERT promoter. , 2010, Journal of the American Chemical Society.

[8]  M. Komiyama,et al.  Telomeric repeat-containing RNA structure in living cells , 2010, Proceedings of the National Academy of Sciences.

[9]  Jean-Louis Mergny,et al.  How long is too long? Effects of loop size on G-quadruplex stability , 2010, Nucleic acids research.

[10]  J. Beaudoin,et al.  5′-UTR G-quadruplex structures acting as translational repressors , 2010, Nucleic acids research.

[11]  J. Mergny,et al.  A G-quadruplex structure within the 5′-UTR of TRF2 mRNA represses translation in human cells , 2010, Nucleic acids research.

[12]  G. Parkinson,et al.  A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex , 2010, Nucleic acids research.

[13]  A. Lane,et al.  Resolution and characterization of the structural polymorphism of a single quadruplex-forming sequence , 2010, Nucleic acids research.

[14]  P. Ryvkin,et al.  Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential , 2009, Nucleic acids research.

[15]  C. Hodgman,et al.  Repression of translation of human estrogen receptor alpha by G-quadruplex formation. , 2009, Biochemistry.

[16]  M. Komiyama,et al.  Consecutive formation of G-quadruplexes in human telomeric-overhang DNA: a protective capping structure for telomere ends. , 2009, Angewandte Chemie.

[17]  A. Benz,et al.  A comparison of DNA and RNA quadruplex structures and stabilities. , 2009, Bioorganic & medicinal chemistry.

[18]  M. Vorlíčková,et al.  Arrangements of human telomere DNA quadruplex in physiologically relevant K+ solutions , 2009, Nucleic acids research.

[19]  L. Hurley,et al.  Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands. , 2009, Journal of the American Chemical Society.

[20]  Daekyu Sun,et al.  Identification and Characterization of Nucleolin as a c-myc G-quadruplex-binding Protein* , 2009, The Journal of Biological Chemistry.

[21]  S. Maiti,et al.  Differential biophysical behavior of human telomeric RNA and DNA quadruplex. , 2009, The journal of physical chemistry. B.

[22]  S. Basu,et al.  An unusually stable G-quadruplex within the 5'-UTR of the MT3 matrix metalloproteinase mRNA represses translation in eukaryotic cells. , 2009, Biochemistry.

[23]  Oliver Stegle,et al.  Predicting and understanding the stability of G-quadruplexes , 2009, Bioinform..

[24]  A. Phan,et al.  Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers. , 2009, Journal of the American Chemical Society.

[25]  Jaroslav Kypr,et al.  Circular dichroism and conformational polymorphism of DNA , 2009, Nucleic acids research.

[26]  A. Phan,et al.  Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K+ solution. , 2009, Journal of the American Chemical Society.

[27]  J. Chaires,et al.  The tail of the telomere. , 2008, Journal of the American Chemical Society.

[28]  Xiuli Wang,et al.  The structural transition and compaction of human telomeric G-quadruplex induced by excluded volume effect under cation-deficient conditions. , 2008, Biophysical chemistry.

[29]  M. Komiyama,et al.  G-quadruplex formation by human telomeric repeats-containing RNA in Na+ solution. , 2008, Journal of the American Chemical Society.

[30]  V. Scaria,et al.  Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif. , 2008, RNA.

[31]  H. Lipps,et al.  Telomerase recruitment by the telomere end binding protein-β facilitates G-quadruplex DNA unfolding in ciliates , 2008, Nature Structural &Molecular Biology.

[32]  M. Teulade‐Fichou,et al.  A hitchhiker's guide to G-quadruplex ligands. , 2008, Organic & biomolecular chemistry.

[33]  Shankar Balasubramanian,et al.  A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes. , 2008, Biochemistry.

[34]  N. Maizels,et al.  Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes , 2008, Nucleic acids research.

[35]  Shantanu Chowdhury,et al.  Quadruplex-coupled kinetics distinguishes ligand binding between G4 DNA motifs. , 2007, Biochemistry.

[36]  Oleg Kikin,et al.  GRSDB2 and GRS_UTRdb: databases of quadruplex forming G-rich sequences in pre-mRNAs and mRNAs , 2007, Nucleic Acids Res..

[37]  F. Johnson,et al.  Genomic distribution and functional analyses of potential G-quadruplex-forming sequences in Saccharomyces cerevisiae , 2007, Nucleic acids research.

[38]  C. Azzalin,et al.  Telomeric Repeat–Containing RNA and RNA Surveillance Factors at Mammalian Chromosome Ends , 2007, Science.

[39]  Carlo Leonetti,et al.  Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. , 2007, The Journal of clinical investigation.

[40]  K. Shin‐ya,et al.  Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action , 2007, Proceedings of the National Academy of Sciences.

[41]  A. Phan,et al.  Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution† , 2007, Nucleic acids research.

[42]  Yong Xue,et al.  Human telomeric DNA forms parallel-stranded intramolecular G-quadruplex in K+ solution under molecular crowding condition. , 2007, Journal of the American Chemical Society.

[43]  Roger A. Jones,et al.  Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence , 2007, Nucleic acids research.

[44]  Leroy F. Liu,et al.  Protection of DNA Ends by Telomeric 3′ G-Tail Sequences* , 2007, Journal of Biological Chemistry.

[45]  D. Pang,et al.  G-quadruplex formation in human telomeric (TTAGGG)4 sequence with complementary strand in close vicinity under molecularly crowded condition , 2007, Nucleic acids research.

[46]  R. Gartenhaus,et al.  Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism , 2007, British Journal of Cancer.

[47]  Shankar Balasubramanian,et al.  An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation. , 2007, Nature chemical biology.

[48]  J. Mergny,et al.  Highly efficient G-quadruplex recognition by bisquinolinium compounds. , 2007, Journal of the American Chemical Society.

[49]  Hamid Morjani,et al.  Telomestatin-induced Telomere Uncapping Is Modulated by POT1 through G-overhang Extension in HT1080 Human Tumor Cells* , 2006, Journal of Biological Chemistry.

[50]  Shankar Balasubramanian,et al.  G-quadruplexes in promoters throughout the human genome , 2006, Nucleic acids research.

[51]  N. Sugimoto,et al.  Characterization of structure and stability of long telomeric DNA G-quadruplexes. , 2006, Journal of the American Chemical Society.

[52]  A. Phan,et al.  Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solution , 2006, Nucleic acids research.

[53]  K. Shin‐ya,et al.  Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin: in vitro and in vivo studies in acute leukemia , 2006, Oncogene.

[54]  J. Mergny,et al.  Human replication protein A unfolds telomeric G-quadruplexes , 2006, Nucleic acids research.

[55]  Yan Xu,et al.  The new models of the human telomere d[AGGG(TTAGGG)3] in K+ solution. , 2006, Bioorganic & medicinal chemistry.

[56]  S. Orlov,et al.  Intracellular Monovalent Ions as Second Messengers , 2006, The Journal of Membrane Biology.

[57]  N. Maizels,et al.  Gene function correlates with potential for G4 DNA formation in the human genome , 2006, Nucleic acids research.

[58]  K. Shin‐ya,et al.  The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells. , 2006, Cancer research.

[59]  Dinshaw J. Patel,et al.  Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold. , 2006, Journal of the American Chemical Society.

[60]  Roger A. Jones,et al.  Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution , 2006, Nucleic acids research.

[61]  T. Bryan,et al.  Extension of G‐quadruplex DNA by ciliate telomerase , 2006, The EMBO journal.

[62]  K. Shin‐ya,et al.  G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3′ telomeric overhang in cancer cells , 2006, Oncogene.

[63]  J. Shay,et al.  Human telomeres have different overhang sizes at leading versus lagging strands. , 2006, Molecular cell.

[64]  T. Ha,et al.  Extreme conformational diversity in human telomeric DNA. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[65]  J. Chaires,et al.  Thermal difference spectra: a specific signature for nucleic acid structures , 2005, Nucleic acids research.

[66]  Jan Postberg,et al.  Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo , 2005, Nature Structural &Molecular Biology.

[67]  J. Correia,et al.  Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal , 2005, Nucleic acids research.

[68]  T. Cech,et al.  Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[69]  W. Wilson,et al.  Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure. , 2005, Journal of the American Chemical Society.

[70]  S. Neidle,et al.  Highly prevalent putative quadruplex sequence motifs in human DNA , 2005, Nucleic acids research.

[71]  Shankar Balasubramanian,et al.  Prevalence of quadruplexes in the human genome , 2005, Nucleic acids research.

[72]  J. Mergny,et al.  Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands , 2005, Oncogene.

[73]  J. Shay,et al.  Telomere-end processing the terminal nucleotides of human chromosomes. , 2005, Molecular cell.

[74]  B. Saccà,et al.  The effect of chemical modifications on the thermal stability of different G-quadruplex-forming oligonucleotides , 2005, Nucleic acids research.

[75]  Stephen Neidle,et al.  The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. , 2005, Cancer research.

[76]  Barbara Benassi,et al.  Biological Activity of the G-Quadruplex Ligand RHPS4 (3,11-Difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) Is Associated with Telomere Capping Alteration , 2004, Molecular Pharmacology.

[77]  Patrick Mailliet,et al.  Stabilization of the c-myc gene promoter quadruplex by specific ligands' inhibitors of telomerase. , 2004, Biochemical and biophysical research communications.

[78]  K. Shin‐ya,et al.  Interaction of Telomestatin with the Telomeric Single-strand Overhang* , 2004, Journal of Biological Chemistry.

[79]  L. Harper,et al.  A bouquet of chromosomes , 2004, Journal of Cell Science.

[80]  N. Maizels,et al.  Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA. , 2004, Genes & development.

[81]  K. Muniyappa,et al.  Meiosis-specific yeast Hop1 protein promotes synapsis of double-stranded DNA helices via the formation of guanine quartets. , 2004, Nucleic acids research.

[82]  Keith R Fox,et al.  Influence of loop size on the stability of intramolecular DNA quadruplexes. , 2004, Nucleic acids research.

[83]  J. Mergny,et al.  Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing. , 2004, Nucleic acids research.

[84]  N. Munshi,et al.  Telomerase Inhibition and Cell Growth Arrest After Telomestatin Treatment in Multiple Myeloma , 2004, Clinical Cancer Research.

[85]  N. Sugimoto,et al.  Duplex dissociation of telomere DNAs induced by molecular crowding. , 2004, Journal of the American Chemical Society.

[86]  A. Phan,et al.  Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: distinct topologies, thermodynamic properties, and folding/unfolding kinetics. , 2003, Journal of the American Chemical Society.

[87]  S. Balasubramanian,et al.  Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[88]  K. Shin‐ya,et al.  Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways , 2003, Oncogene.

[89]  L. Hurley,et al.  The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures. , 2003, Cancer research.

[90]  N. Maizels,et al.  G4 DNA unwinding by BLM and Sgs1p: substrate specificity and substrate-specific inhibition. , 2002, Nucleic acids research.

[91]  D. Bearss,et al.  Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[92]  Stephen Neidle,et al.  Crystal structure of parallel quadruplexes from human telomeric DNA , 2002, Nature.

[93]  Kazuo Shin-Ya,et al.  Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex. , 2002, Journal of the American Chemical Society.

[94]  J. Darnell,et al.  Fragile X Mental Retardation Protein Targets G Quartet mRNAs Important for Neuronal Function , 2001, Cell.

[95]  J. Darnell,et al.  Microarray Identification of FMRP-Associated Brain mRNAs and Altered mRNA Translational Profiles in Fragile X Syndrome , 2001, Cell.

[96]  I Berger,et al.  In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[97]  Ian D. Hickson,et al.  The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases , 2001, Nucleic Acids Res..

[98]  Stephen Neidle,et al.  Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[99]  K. Shin‐ya,et al.  Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus. , 2001, Journal of the American Chemical Society.

[100]  L. Loeb,et al.  Human Werner Syndrome DNA Helicase Unwinds Tetrahelical Structures of the Fragile X Syndrome Repeat Sequence d(CGG) n * , 1999, The Journal of Biological Chemistry.

[101]  N. Maizels,et al.  The Bloom’s Syndrome Helicase Unwinds G4 DNA* , 1998, The Journal of Biological Chemistry.

[102]  O. Fedoroff,et al.  NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA. , 1998, Biochemistry.

[103]  R. Wheelhouse,et al.  Cationic Porphyrins as Telomerase Inhibitors: the Interaction of Tetra-(N-methyl-4-pyridyl)porphine with Quadruplex DNA , 1998 .

[104]  J. Shay,et al.  Normal human chromosomes have long G-rich telomeric overhangs at one end. , 1997, Genes & development.

[105]  S. Neidle,et al.  Inhibition of human telomerase by a G-quadruplex-interactive compound. , 1997, Journal of medicinal chemistry.

[106]  R. Wellinger,et al.  The terminal DNA structure of mammalian chromosomes , 1997, The EMBO journal.

[107]  J. Langmore,et al.  Long G Tails at Both Ends of Human Chromosomes Suggest a C Strand Degradation Mechanism for Telomere Shortening , 1997, Cell.

[108]  D. F. Ogletree,et al.  Probing the interaction between single molecules: fluorescence resonance energy transfer between a single donor and a single acceptor , 1996, Summaries of Papers Presented at the Quantum Electronics and Laser Science Conference.

[109]  D. Patel,et al.  Solution structure of the Tetrahymena telomeric repeat d(T2G4)4 G-tetraplex. , 1994, Structure.

[110]  P. Balagurumoorthy,et al.  Structure and stability of human telomeric sequence. , 1994, The Journal of biological chemistry.

[111]  P C Moody,et al.  The high-resolution crystal structure of a parallel-stranded guanine tetraplex. , 1994, Science.

[112]  W. Gilbert,et al.  The yeast KEM1 gene encodes a nuclease specific for G4 tetraplex DNA: Implication of in vivo functions for this novel DNA structure , 1994, Cell.

[113]  J. Feigon,et al.  Refined solution structure of the dimeric quadruplex formed from the Oxytricha telomeric oligonucleotide d(GGGGTTTTGGGG). , 1994, Structure.

[114]  D. Patel,et al.  Solution structure of a parallel-stranded G-quadruplex DNA. , 1993, Journal of molecular biology.

[115]  D. Patel,et al.  Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex. , 1993, Structure.

[116]  J. Feigon,et al.  Strand orientation in the DNA quadruplex formed from the Oxytricha telomere repeat oligonucleotide d(G4T4G4) in solution. , 1993, Biochemistry.

[117]  D. Patel,et al.  Guanine residues in d(T2AG3) and d(T2G4) form parallel-stranded potassium cation stabilized G-quadruplexes with anti glycosidic torsion angles in solution. , 1992, Biochemistry.

[118]  M. Bansal,et al.  Hairpin and parallel quartet structures for telomeric sequences. , 1992, Nucleic acids research.

[119]  A. Rich,et al.  Crystal structure of four-stranded Oxytricha telomeric DNA , 1992, Nature.

[120]  J. Feigon,et al.  Quadruplex structure of Oxytricha telomeric DNA oligonucleotides , 1992, Nature.

[121]  C. C. Hardin,et al.  Monovalent cation induced structural transitions in telomeric DNAs: G-DNA folding intermediates. , 1991, Biochemistry.

[122]  David M. Prescott,et al.  Inhibition of telomerase by G-quartet DMA structures , 1991, Nature.

[123]  E. I. Budowsky,et al.  G-DNA: a twice-folded DNA structure adopted by single-stranded oligo(dG) and its implications for telomeres. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[124]  Aaron Klug,et al.  Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops , 1989, Nature.

[125]  T. Cech,et al.  Monovalent cation-induced structure of telomeric DNA: The G-quartet model , 1989, Cell.

[126]  W. Gilbert,et al.  Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis , 1988, Nature.

[127]  C. C. Hardin,et al.  Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine·guanine base pairs , 1987, Cell.

[128]  H. Lipps.  In vitro aggregation of the gene-sized DNA molecules of the ciliate Stylonychia mytilus. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[129]  W. Guschlbauer,et al.  Physicochemical properties of nucleosides 3. Gel formation by 8‐bromoguanosine , 1969, FEBS letters.

[130]  D. Davies,et al.  Helix formation by guanylic acid. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[131]  H. Khorana,et al.  Secondary Structure and Aggregation in Deoxyguanosine Oligonucleotides , 1962 .

[132]  L. Marky,et al.  Monitoring the temperature unfolding of G-quadruplexes by UV and circular dichroism spectroscopies and calorimetry techniques. , 2010, Methods in molecular biology.

[133]  M. Jarstfer,et al.  Preparation of G-quartet structures and detection by native gel electrophoresis. , 2010, Methods in molecular biology.

[134]  T. Ha,et al.  Real-time observation of G-quadruplex dynamics using single-molecule FRET microscopy. , 2010, Methods in molecular biology.

[135]  L. Hurley,et al.  Biochemical techniques for the characterization of G-quadruplex structures: EMSA, DMS footprinting, and DNA polymerase stop assay. , 2010, Methods in molecular biology.

[136]  J. Postberg,et al.  Probing telomeric G-quadruplex DNA structures in cells with in vitro generated single-chain antibody fragments. , 2010, Methods in molecular biology.

[137]  L. Cox.  Molecular themes in DNA replication , 2009 .

[138]  Jean-Louis Mergny,et al.  Targeting telomeres and telomerase. , 2008, Biochimie.

[139]  C. C. Hardin,et al.  Thermodynamic and kinetic characterization of the dissociation and assembly of quadruplex nucleic acids , 2000, Biopolymers.

[140]  G. Thomas,et al.  A phase diagram for sodium and potassium ion control of polymorphism in telomeric DNA. , 1995, Journal of molecular biology.

[141]  J. R. Williamson,et al.  G-quartet structures in telomeric DNA. , 1994, Annual review of biophysics and biomolecular structure.