Intrathecal, but not intravenous adenosine reduces allodynia in patients with neuropathic pain

[1]  P. Manfredi Opioids versus antidepressants in postherpetic neuralgia: A randomized, placebo-controlled trial , 2003, Neurology.

[2]  J. Eisenach,et al.  Dose Response of Intrathecal Adenosine in Experimental Pain and Allodynia , 2002, Anesthesiology.

[3]  J. Eisenach,et al.  Phase I Safety Assessment of Intrathecal Injection of an American Formulation of Adenosine in Humans , 2002, Anesthesiology.

[4]  J. Eisenach,et al.  Preliminary Efficacy Assessment of Intrathecal Injection of an American Formulation of Adenosine in Humans , 2002, Anesthesiology.

[5]  M. Max,et al.  Mechanism-based Pain Diagnosis: Issues for Analgesic Drug Development , 2001, Anesthesiology.

[6]  M. Rowbotham,et al.  Effect of Systemic Adenosine on Pain and Secondary Hyperalgesia Associated With the Heat/Capsaicin Sensitization Model in Healthy Volunteers , 2001, Regional Anesthesia & Pain Medicine.

[7]  A. Sollevi,et al.  Intrathecal adenosine administration in abdominal hysterectomy lacks analgesic effect , 2000, Acta anaesthesiologica Scandinavica.

[8]  J. Eisenach,et al.  Relative potency of epidural to intrathecal clonidine differs between acute thermal pain and capsaicin-induced allodynia , 2000, Pain.

[9]  J. A. Gomes,et al.  Intrathecal adenosine interacts with a spinal noradrenergic system to produce antinociception in nerve-injured rats. , 1999, Anesthesiology.

[10]  A. Sollevi,et al.  The safety and efficacy of intrathecal adenosine in patients with chronic neuropathic pain. , 1999, Anesthesia and analgesia.

[11]  J. Eisenach,et al.  Intrathecal adenosine: interactions with spinal clonidine and neostigmine in rat models of acute nociception and postoperative hypersensitivity. , 1999, Anesthesiology.

[12]  J. Eisenach,et al.  Exogenous and endogenous adenosine enhance the spinal antiallodynic effects of morphine in a rat model of neuropathic pain , 1999, Pain.

[13]  A. Sollevi,et al.  Intrathecal Adenosine Administration: A Phase 1 Clinical Safety Study in Healthy Volunteers, with Additional Evaluation of Its Influence on Sensory Thresholds and Experimental Pain , 1998, Anesthesiology.

[14]  J. Eisenach,et al.  Intrathecal, but Not Intravenous, Clonidine Reduces Experimental Thermal or Capsaicin-Induced Pain and Hyperalgesia in Normal Volunteers , 1998, Anesthesia and analgesia.

[15]  F. Benedetti,et al.  Dose-response relationship of opioids in nociceptive and neuropathic postoperative pain , 1998, Pain.

[16]  W. Kingery,et al.  A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes , 1997, Pain.

[17]  T. Yaksh,et al.  Pharmacology and mechanisms of opioid analgesic activity , 1997, Acta anaesthesiologica Scandinavica.

[18]  T. Yaksh,et al.  Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists. , 1996, The Journal of pharmacology and experimental therapeutics.

[19]  A. Sollevi,et al.  Systemic Adenosine Infusion Alleviates Spontaneous and Stimulus Evoked Pain in Patients with Peripheral Neuropathic Pain , 1995, Anesthesia and analgesia.

[20]  J. Eisenach,et al.  Epidural clonidine analgesia for intractable cancer pain , 1995, Pain.

[21]  T. Gordh,et al.  An A1-selective adenosine agonist abolishes allodynia elicited by vibration and touch after intrathecal injection. , 1995, Anesthesia and analgesia.

[22]  A. Sollevi,et al.  Systemic adenosine infusion: a new treatment modality to alleviate neuropathic pain , 1995, Pain.

[23]  A. Sollevi Adenosine infusion during isoflurane‐nitrous oxide anaesthesia: indications of perioperative analgesic effect , 1992, Acta anaesthesiologica Scandinavica.

[24]  R. Isbrucker,et al.  Adenosine mediates calcium-induced antinociception and potentiation of noradrenergic antinociception in the spinal cord , 1990, Brain Research.

[25]  T. White,et al.  Classification of adenosine receptors mediating antinociception in the rat spinal cord , 1986, British journal of pharmacology.

[26]  C J Robinson,et al.  Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: a comparison of neural events in monkey with sensory judgments in human. , 1983, Journal of neurophysiology.

[27]  R. Myers,et al.  Preclinical toxicity screening of intrathecal adenosine in rats and dogs. , 1999, Anesthesiology.