Empirical evaluation of general-purpose image features for pathology-oriented image retrieval of Alzheimer Disease cases

Purpose: To evaluate the applicability of general-purpose image feature algo- rithms as effective and efficient descriptors for pathology-based image retrieval of Magnetic Resonance Imaging (MRI) brain volumes under the hypothesis that localized quantitative visual similarity associates consistently with the pathological state in Alzheimer Dis- ease (AD).