Relation Inference and Type Identification Based on Brain Knowledge Graph

Large-scale brain knowledge bases, such as Linked Brain Data, integrate and synthesize domain knowledge on the brain from various data sources. Although it is designed to provide comprehensive understanding of the brain from multiple perspectives and multi-scale, the correctness and specificity of the extracted knowledge is very important. In this paper, we propose a framework of relation inference and relation type identification to solve the upper problem. Firstly, we propose a quadrilateral closure method based on the network topology to verify and infer the binary relations. Secondly, we learn a model based on artificial neural network to predict the potential relations. Finally, we propose a model free method to identify the specific type of relations based on dependency parsing. We test our verified relations on the annotated data, and the result demonstrates a promising performance.

[1]  Dimitris Papadias,et al.  Topological Inference , 1995, IJCAI.

[2]  C. Eckman,et al.  Molecular Characterization of Mutations That Cause Globoid Cell Leukodystrophy and Pharmacological Rescue Using Small Molecule Chemical Chaperones , 2010, The Journal of Neuroscience.

[3]  Jun Zhao,et al.  Relation Classification via Convolutional Deep Neural Network , 2014, COLING.

[4]  Anatol Rapoport,et al.  Spread of information through a population with socio-structural bias: III. Suggested experimental procedures , 1954 .

[5]  Ralph Grishman,et al.  Discovering Relations among Named Entities from Large Corpora , 2004, ACL.

[6]  A. Vázquez,et al.  Network clustering coefficient without degree-correlation biases. , 2005, Physical review. E, Statistical, nonlinear, and soft matter physics.

[7]  Glenda MacQueen,et al.  Psychological Factors in Asthma , 2008, Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology.

[8]  Razvan C. Bunescu,et al.  A Shortest Path Dependency Kernel for Relation Extraction , 2005, HLT.

[9]  Gueorgi Kossinets,et al.  Empirical Analysis of an Evolving Social Network , 2006, Science.

[10]  Lei Liu,et al.  Automatic Verification of "isa" Relations Based on Features , 2009, 2009 Sixth International Conference on Fuzzy Systems and Knowledge Discovery.

[11]  Danqi Chen,et al.  A Fast and Accurate Dependency Parser using Neural Networks , 2014, EMNLP.

[12]  Yi Zeng,et al.  Brain Knowledge Graph Analysis Based on Complex Network Theory , 2016, BIH.

[13]  Jean-Cédric Chappelier,et al.  Large-scale extraction of brain connectivity from the neuroscientific literature , 2015, Bioinform..

[14]  Aron Culotta,et al.  Dependency Tree Kernels for Relation Extraction , 2004, ACL.

[15]  Yi Zeng,et al.  Linked Neuron Data (LND): A Platform for Integrating and Semantically Linking Neuroscience Data and Knowledge , 2014 .

[16]  Mark S. Granovetter The Strength of Weak Ties , 1973, American Journal of Sociology.

[17]  Oren Etzioni,et al.  Open Information Extraction from the Web , 2007, CACM.

[18]  A Dean Befus The Mind-Body of Allergic Diseases , 2008, Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology.

[19]  T. Newcomb An approach to the study of communicative acts. , 1953, Psychological review.

[20]  A. Goate,et al.  Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort , 2012, Alzheimer's Research & Therapy.