The role of magnetic assisted capsule endoscopy (MACE) to aid visualisation in the upper GI tract

Examination of the upper gastrointestinal tract by a standard endoscope is often thought as a daunting experience to many who have undertaken or are about to undergo the procedure. The overall perceived size of the gastroscope, unpleasantness of stimulation of the gag reflex and the need often for sedation is discouraging to many. A method to visualise the upper gastrointestinal mucosa which negates the need for sedation, the associated expensive decontamination costs and the possibility of having a community based examination would be particularly welcoming to this endoscopy field. Since the first swallow of a capsule endoscope by a human volunteer in 1999, their usage for examining the small bowel has exponentially grown to that of over a million patients worldwide. More recently, innovation in this field have shown plausibility for its use to visualise the upper gastrointestinal tract, with the integration of magnets within the capsule the most promising method.

[1]  S. Song,et al.  A novel microactuator for microbiopsy in capsular endoscopes , 2008 .

[2]  Xiang Chen,et al.  A meta-analysis of the yield of capsule endoscopy compared to double-balloon enteroscopy in patients with small bowel diseases. , 2007, World journal of gastroenterology.

[4]  P ? ? ? ? ? ? ? % ? ? ? ? , 1991 .

[5]  Y. Kuo,et al.  Capsule endoscopy with PILLCAM ESO for detecting esophageal varices: a meta-analysis. , 2011, Minerva gastroenterologica e dietologica.

[6]  Praful Patel,et al.  PTU-028 First Human Series Of Magnet Assisted Capsule Endoscopy (mace) In The Upper Gi Tract Using The Novel Mirocam-navi System , 2014, Gut.

[7]  Thomas Rösch,et al.  Magnetically Guided Capsule Versus Conventional Gastroscopy for Upper Abdominal Complaints: A Prospective Blinded Study , 2015, Journal of clinical gastroenterology.

[8]  Z. Liao,et al.  Feasibility and safety of magnetic-controlled capsule endoscopy system in examination of human stomach: a pilot study in healthy volunteers. , 2012, Journal of interventional gastroenterology.

[9]  Emanuele Rondonotti,et al.  Diagnostic yield of small-bowel capsule endoscopy in patients with iron-deficiency anemia: a systematic review. , 2012, Gastrointestinal endoscopy.

[10]  Paul Swain,et al.  Remote magnetic control of a wireless capsule endoscope in the esophagus is safe and feasible: results of a randomized, clinical trial in healthy volunteers. , 2010, Gastrointestinal endoscopy.

[11]  In Seok Lee,et al.  Detection of Neoplastic Gastric Lesions Using Capsule Endoscopy: Pilot Study , 2013, Gastroenterology research and practice.

[12]  S. Song,et al.  First clinical trial of the "MiRo" capsule endoscope by using a novel transmission technology: electric-field propagation. , 2009, Gastrointestinal endoscopy.

[13]  Federico Carpi,et al.  Magnetic shells for gastrointestinal endoscopic capsules as a means to control their motion. , 2006, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[14]  J. Magalhães,et al.  Finding the solution for incomplete small bowel capsule endoscopy. , 2013, World journal of gastrointestinal endoscopy.

[15]  J. Rey,et al.  Feasibility of stomach exploration with a guided capsule endoscope. , 2010, Endoscopy.

[16]  P. Swain,et al.  Inspection of the human stomach using remote-controlled capsule endoscopy: a feasibility study in healthy volunteers (with videos). , 2011, Gastrointestinal endoscopy.

[17]  Metin Sitti,et al.  Biopsy using a Magnetic Capsule Endoscope Carrying, Releasing, and Retrieving Untethered Microgrippers , 2014, IEEE Transactions on Biomedical Engineering.

[18]  Olle Broström,et al.  Capsule Retentions and Incomplete Capsule Endoscopy Examinations: An Analysis of 2300 Examinations , 2011, Gastroenterology research and practice.

[19]  Konstantinos Triantafyllou,et al.  Colon capsule endoscopy is feasible to perform after incomplete colonoscopy and guides further workup in clinical practice. , 2014, Gastrointestinal endoscopy.

[20]  P. Swain,et al.  Remote magnetic manipulation of a wireless capsule endoscope in the esophagus and stomach of humans (with videos). , 2010, Gastrointestinal endoscopy.

[21]  Moshe Rubin,et al.  Pillcam ESO® is more accurate than clinical scoring systems in risk stratifying emergency room patients with acute upper gastrointestinal bleeding , 2013, Therapeutic advances in gastroenterology.

[22]  Atsuo Yamada,et al.  Diagnostic yield of capsule endoscopy for gastric diseases , 2012, Abdominal Imaging.

[23]  Guido Costamagna,et al.  Second-generation colon capsule endoscopy compared with colonoscopy. , 2011, Gastrointestinal endoscopy.

[24]  Borislav Dimitrov,et al.  Optimizing the performance of magnetic-assisted capsule endoscopy of the upper GI tract using multiplanar CT modelling , 2015, European journal of gastroenterology & hepatology.

[25]  S. Kudo,et al.  Blinded nonrandomized comparative study of gastric examination with a magnetically guided capsule endoscope and standard videoendoscope. , 2012, Gastrointestinal endoscopy.