Strategies to assess systemic exposure of chemicals in subchronic/chronic diet and drinking water studies.

[1]  Charles Timchalk,et al.  Comparative inter-species pharmacokinetics of phenoxyacetic acid herbicides and related organic acids. evidence that the dog is not a relevant species for evaluation of human health risk. , 2004, Toxicology.

[2]  B. van Ravenzwaay,et al.  Comparative metabolism of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat and dog , 2003, Xenobiotica; the fate of foreign compounds in biological systems.

[3]  I. Schultz,et al.  Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naive and GST-zeta-depleted rats. , 2002, Environmental health perspectives.

[4]  I. Schultz,et al.  Dichloroacetate toxicokinetics and disruption of tyrosine catabolism in B6C3F1 mice: dose-response relationships and age as a modifying factor. , 2002, Toxicology.

[5]  C Timchalk,et al.  A Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.

[6]  J L Mattsson,et al.  Lack of differential sensitivity to cholinesterase inhibition in fetuses and neonates compared to dams treated perinatally with chlorpyrifos. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[7]  B. Yano,et al.  Single-dose and chronic dietary neurotoxicity screening studies on 2,4-dichlorophenoxyacetic acid in rats. , 1997, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[8]  I. Mahmood.  A comparative computer simulation study of three different sparse-sampling methods for the estimation of steady-state area under the concentration-time curve (AUC) and maximum concentration (Cmax) in toxicokinetics. , 1997, Journal of pharmaceutical sciences.

[9]  J. Bus,et al.  Comparative subchronic studies on 2,4-dichlorophenoxyacetic acid, amine, and ester in rats. , 1996, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[10]  J. Nedelman,et al.  Serial Versus Sparse Sampling in Toxicokinetic Studies , 1996, Pharmaceutical Research.

[11]  C. Buggé,et al.  Effects of gavage versus dosed feed administration on the toxicokinetics of benzyl acetate in rats and mice. , 1995, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[12]  R. Jochemsen,et al.  Assessment of drug exposure in rat dietary studies. , 1993, Xenobiotica; the fate of foreign compounds in biological systems.

[13]  J. Nedelman,et al.  Assessing drug exposure in rodent toxicity studies without satellite animals , 1993, Journal of Pharmacokinetics and Biopharmaceutics.

[14]  J Yuan,et al.  Modeling blood/plasma concentrations in dosed feed and dosed drinking water toxicology studies. , 1993, Toxicology and applied pharmacology.

[15]  L. Chasseaud.  The Importance of Pharmacokinetic/Toxicokinetic and Metabolic Information in Carcinogenicity Study Design , 1992 .

[16]  A. Monro,et al.  Diurnal exposure profile in rats from dietary administration of a chemical (doxazosin) with a short half‐life: Interplay of age and diurnal feeding pattern , 1992, Journal of applied toxicology : JAT.

[17]  A. Monro,et al.  What is an appropriate measure of exposure when testing drugs for carcinogenicity in rodents? , 1992, Toxicology and applied pharmacology.

[18]  A. Renwick,et al.  The pharmacokinetics and tissue concentrations of cyclohexylamine in rats and mice. , 1989, Toxicology and applied pharmacology.

[19]  R. Yeary.  Urinary Excretion of 2,4-D in Commercial Lawn Specialists , 1986 .

[20]  A. Renwick,et al.  The tissue distribution and pharmacokinetics of saccharin in the rat. , 1980, Toxicology and applied pharmacology.

[21]  G. Blau,et al.  The fate of 2,4-dichlorophenoxyacetic acid (2,4-D) following oral administration to man. , 1977, Toxicology.

[22]  R. Irwin,et al.  Toxicokinetics of pentachlorophenol in the F344 rat. Gavage and dosed feed studies. , 1994, Xenobiotica; the fate of foreign compounds in biological systems.

[23]  J. Caron,et al.  Disposition of 2,4-dichlorophenoxyacetic acid dimethylamine by Fischer 344 rats dosed orally and dermally. , 1989, Journal of toxicology and environmental health.