Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications.
暂无分享,去创建一个
[1] R. Evans,et al. Mechanism of corepressor binding and release from nuclear hormone receptors. , 1999, Genes & development.
[2] M. Lazar,et al. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors , 1999, Nature.
[3] B. Spiegelman,et al. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[4] Zbigniew Dauter,et al. Molecular basis of agonism and antagonism in the oestrogen receptor , 1997, Nature.
[5] T. Willson,et al. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ , 1998, Nature.
[6] L. Freedman,et al. 20-Epi Analogues of 1,25-Dihydroxyvitamin D3 Are Highly Potent Inducers of DRIP Coactivator Complex Binding to the Vitamin D3 Receptor* , 1999, The Journal of Biological Chemistry.
[7] V. Giguère,et al. Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1. , 1999, Molecular cell.
[8] Jean-Paul Renaud,et al. Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid , 1995, Nature.
[9] P B Sigler,et al. Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[10] C. Glass,et al. The coregulator exchange in transcriptional functions of nuclear receptors. , 2000, Genes & development.
[11] R. Lanz,et al. Nuclear receptor coregulators: cellular and molecular biology. , 1999, Endocrine reviews.
[12] R J Fletterick,et al. Structure and specificity of nuclear receptor-coactivator interactions. , 1998, Genes & development.
[13] D. Fowlkes,et al. Dissection of the LXXLL Nuclear Receptor-Coactivator Interaction Motif Using Combinatorial Peptide Libraries: Discovery of Peptide Antagonists of Estrogen Receptors α and β , 1999, Molecular and Cellular Biology.
[14] P. Chambon,et al. Conformational adaptation of agonists to the human nuclear receptor RARγ , 1998, Nature Structural Biology.
[15] H Grøn,et al. Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[16] D. Moras,et al. Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[17] Jacek Ostrowski,et al. Two distinct actions of retinoid-receptor ligands , 1996, Nature.
[18] P. Sigler,et al. Atomic structure of progesterone complexed with its receptor , 1998, Nature.
[19] Mary E. McGrath,et al. A structural role for hormone in the thyroid hormone receptor , 1995, Nature.
[20] B. Spiegelman,et al. Terminal differentiation of human breast cancer through PPAR gamma. , 1998, Molecular cell.
[21] P. Chambon,et al. Role of the two activating domains of the oestrogen receptor in the cell‐type and promoter‐context dependent agonistic activity of the anti‐oestrogen 4‐hydroxytamoxifen. , 1990, The EMBO journal.
[22] V. Jordan,et al. Basic guide to the mechanisms of antiestrogen action. , 1998, Pharmacological reviews.
[23] J. Gustafsson,et al. Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists. , 1998, Molecular pharmacology.
[24] J. Gustafsson,et al. Cloning of a novel receptor expressed in rat prostate and ovary. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[25] C. Glass,et al. Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation. , 1998, Genes & development.
[26] L. Freedman,et al. Nuclear receptor cofactors as chromatin remodelers. , 1999, Current opinion in genetics & development.
[27] D. Moras,et al. The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand. , 2000, Molecular cell.
[28] J. Lehmann,et al. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. , 2000, Molecular cell.
[29] P. Meltzer,et al. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. , 1997, Science.
[30] P. Chambon,et al. Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains. , 2000, Molecular cell.
[31] P Chambon,et al. Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. , 1999, Chemistry & biology.
[32] P. Chambon,et al. RAR‐specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage‐independent cell proliferation. , 1995, The EMBO journal.
[33] M Carlquist,et al. Structure of the ligand‐binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist , 1999, The EMBO journal.
[34] M Carlquist,et al. Structural aspects of agonism and antagonism in the oestrogen receptor. , 2000, Biochemical Society transactions.
[35] P. Chambon,et al. Crystal structure of the human RXRα ligand‐binding domain bound to its natural ligand: 9‐cis retinoic acid , 2000 .
[36] J. Lehmann,et al. An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway , 1998, Cell.
[37] C. Glass,et al. Molecular determinants of nuclear receptor-corepressor interaction. , 1999, Genes & development.
[38] D. Mangelsdorf,et al. Nuclear receptor regulation of cholesterol and bile acid metabolism. , 1999, Current opinion in biotechnology.
[39] R. Roeder,et al. HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. , 2000, Molecular cell.
[40] J. Gustafsson,et al. Differential Response of Estrogen Receptor a and Estrogen Receptor b to Partial Estrogen Agonists/Antagonists , 1998 .
[41] David A. Agard,et al. The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen , 1998, Cell.
[42] J. Lehmann,et al. A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[43] Millard H. Lambert,et al. Asymmetry in the PPARγ/RXRα Crystal Structure Reveals the Molecular Basis of Heterodimerization among Nuclear Receptors , 2000 .
[44] W. Wahli,et al. Peroxisome proliferator-activated receptors: nuclear control of metabolism. , 1999, Endocrine reviews.
[45] H. Gronemeyer,et al. Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo. , 1997, Molecular Endocrinology.
[46] I. Issemann,et al. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators , 1990, Nature.
[47] David M. Heery,et al. A signature motif in transcriptional co-activators mediates binding to nuclear receptors , 1997, Nature.
[48] R. Evans,et al. The RXR heterodimers and orphan receptors , 1995, Cell.
[49] P. Puigserver,et al. A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis , 1998, Cell.
[50] L. Hamann,et al. Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists , 1997, Nature.
[51] L. Jendeberg,et al. Crystal Structure of the Ligand Binding Domain of the Human Nuclear Receptor PPARγ* , 1998, The Journal of Biological Chemistry.
[52] B. Katzenellenbogen,et al. Novel Ligands that Function as Selective Estrogens or Antiestrogens for Estrogen Receptor-α or Estrogen Receptor-β. , 1999, Endocrinology.
[53] William Bourguet,et al. A canonical structure for the ligand-binding domain of nuclear receptors , 1996, Nature Structural Biology.
[54] L. Freedman. Increasing the Complexity of Coactivation in Nuclear Receptor Signaling , 1999, Cell.
[55] H. Gronemeyer,et al. Transcription factors 3: nuclear receptors. , 1995, Protein profile.
[56] S. Yeh,et al. Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[57] P. Herrlich,et al. Transcriptional cross-talk, the second mode of steroid hormone receptor action , 1998, Journal of Molecular Medicine.
[58] W. Sabbagh,et al. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. , 1998, Genes & development.
[59] F. Claessens,et al. Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform. , 1999, Molecular endocrinology.
[60] H. Gronemeyer,et al. Therapeutic potential of selective modulators of nuclear receptor action. , 1998, Current opinion in chemical biology.
[61] William Bourguet,et al. Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α , 1995, Nature.