Voriconazole In situ Gel for Ocular Drug Delivery

Fungal keratitis is an important cause of vision loss in developing countries characterized by a corneal epithelial defect and inflammation of the corneal stroma [17]. Currently, fungal keratitis remains a perplexing diagnostic challenge and a difficult management problem for ophthalmologists [7]. Various factors responsible for development of fungal karatitis includes ocular trauma, contamination of corneal lesions by soil and plant material, use of broad spectrum antibiotics and steroids use of contact lenses. Another important factor to be considered supportive to fungal karatitis are climatic conditions mainly temperate climate and tropical climate [10]. Early diagnosis of fungal keratitis and its treatment is important in preventing Abstract