A high-voltage, high-current CMOS pulse generator ASIC for deep brain stimulation

A high-voltage, high-current pulse generator ASIC based on 0.35-εm high-voltage CMOS technology is presented. The chip has eight independently-controlled biphasic output channels that can generate either current- or voltage-controlled pulses. The output driver is capable of delivering current up to 1.26 mA or 5.04 mA and voltage up to 2.36 V or 9.45 V; all with 6-bit resolution. The stimulation frequency can be adjusted between 3 Hz to 5 kHz, while pulse width can vary from 20 µs to 640 εs in 20 εs steps for 100-kHz clock frequency. The timing parameters can be adjusted further by varying the clock frequency. These parameters, including pulse phase, can be programmed independently in each channel to allow different waveform generation. The foregoing provides an on-chip solution for an arbitrary function generator that can be monolithically fabricated with the rest of the circuitry. Based on its configuration this chip is an ideal solution for deep brain stimulation (DBS) electrode for targeted stimulation through current steering.

[1]  J. Volkmann,et al.  Basic algorithms for the programming of deep brain stimulation in Parkinson's disease , 2006, Movement disorders : official journal of the Movement Disorder Society.

[2]  M. Lanotte,et al.  Freezing and hypokinesia of gait induced by stimulation of the subthalamic region , 2007, Journal of the Neurological Sciences.

[3]  Grant A. McCallum,et al.  3-D microfabricated electrodes for targeted deep brain stimulation , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[4]  Laura Cif,et al.  Evolution of Brain Impedance in Dystonic Patients Treated by GPi Electrical Stimulation , 2004, Neuromodulation : journal of the International Neuromodulation Society.

[5]  M. Ortmanns,et al.  A 0.1mm/sup 2/, Digitally Programmable Nerve Stimulation Pad Cell with High-Voltage Capability for a Retinal Implant , 2006, 2006 IEEE International Solid State Circuits Conference - Digest of Technical Papers.

[6]  A. Benabid,et al.  Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus , 1991, The Lancet.

[7]  S.K. Kelly,et al.  A power-efficient voltage-based neural tissue stimulator with energy recovery , 2004, 2004 IEEE International Solid-State Circuits Conference (IEEE Cat. No.04CH37519).

[8]  Maysam Ghovanloo,et al.  A compact large Voltage-compliance high output-impedance programmable current source for implantable microstimulators , 2005, IEEE Transactions on Biomedical Engineering.

[9]  Kari Halonen,et al.  On-chip Digitally Tunable High Voltage Generator for Electrostatic Control of Micromechanical Devices , 2006, IEEE Custom Integrated Circuits Conference 2006.