Clinical, epidemiological, and therapeutic profile of dermatophytosis*

BACKGROUND The cutaneous mycoses, mainly caused by dermatophyte fungi, are among the most common fungal infections worldwide. It is estimated that 10% to 15% of the population will be infected by a dermatophyte at some point in their lives, thus making this a group of diseases with great public health importance. OBJECTIVE To analyze the clinical, epidemiological, and therapeutic profile of dermatophytosis in patients enrolled at the Dermatology service of Universidade do Estado do Pará, Brazil, from July 2010 to September 2012. METHOD A total of 145 medical records of patients diagnosed with dermatophytosis were surveyed. Data were collected and subsequently recorded according to a protocol developed by the researchers. This protocol consisted of information regarding epidemiological and clinical aspects of the disease and the therapy employed. RESULTS The main clinical form of dermatophyte infection was onychomycosis, followed by tinea corporis, tinea pedis, and tinea capitis. Furthermore, the female population and the age group of 51 to 60 years were the most affected. Regarding therapy, there was a preference for treatments that combine topical and systemic drugs, and the most widely used drugs were fluconazole (systemic) and ciclopirox olamine (topical). CONCLUSION This study showed the importance of recurrent analysis of the epidemiological profile of dermatophytosis to enable correct therapeutic and preventive management of these conditions, which have significant clinical consequences, with chronic, difficult-totreat lesions that can decrease patient quality of life and cause disfigurement.

[1]  D. Torgerson,et al.  Oral treatments for fungal infections of the skin of the foot. , 2012, The Cochrane database of systematic reviews.

[2]  A. C. Cortez,et al.  Frequency and aetiology of dermatophytosis in children age 12 and under in the state of Amazonas, Brazil. , 2012, Revista iberoamericana de micologia.

[3]  M. Mokni,et al.  Letter: Tinea capitis in infants in their first 2 years of life: A 12-year study and a review of the literature. , 2012, Dermatology online journal.

[4]  S. Maraki Epidemiology of dermatophytoses in Crete, Greece between 2004 and 2010. , 2012, Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia.

[5]  Michel Fleith Otuki,et al.  Eficácia de antifúngicos tópicos em diferentes dermatomicoses: uma revisão sistemática com metanálise , 2012 .

[6]  A. Sanches,et al.  Efficacy of topical antifungal drugs in different dermatomycoses: a systematic review with meta-analysis. , 2012, Revista da Associacao Medica Brasileira.

[7]  G. Vena,et al.  Epidemiology of dermatophytoses: retrospective analysis from 2005 to 2010 and comparison with previous data from 1975. , 2012, The new microbiologica.

[8]  P. Nenoff,et al.  [Fungal nail infections--an update: Part 1--Prevalence, epidemiology, predisposing conditions, and differential diagnosis]. , 2012, Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete.

[9]  P. Nenoff,et al.  Onychomykose – ein Update , 2011, Der Hautarzt.

[10]  D. Heidrich,et al.  Antifungal susceptibility of dermatophytes isolated from patients with chronic renal failure. , 2011, Anais brasileiros de dermatologia.

[11]  H. Lackner,et al.  Prevalence of tinea capitis in Southeastern Austria between 1985 and 2008: up‐to‐date picture of the current situation , 2011, Mycoses.

[12]  E. Chryssanthou,et al.  Epidemiology of dermatophyte infections in Stockholm, Sweden: a retrospective study from 2005-2009. , 2010, Medical mycology.

[13]  S. Prasad,et al.  INTERMITTENT PULSE-DOSED TERBINAFINE IN THE TREATMENT OF TINEA CORPORIS AND/OR TINEA CRURIS , 2011, Indian Journal of Dermatology.

[14]  Francinete Carla Nunes Cavalcanti,et al.  Superficial mycoses in Paraíba: a comparative analysis and bibliographical revision. , 2010, Anais brasileiros de dermatologia.

[15]  F. C. A. Maranhão,et al.  Dermatófitos: interação patógeno-hospedeiro e resistência a antifúngicos , 2010 .

[16]  A. Fuentefria,et al.  Prevalência de dermatófitos na rotina de micologia em hospital particular de médio porte na cidade de Chapecó, estado de Santa Catarina, Brasil , 2010 .

[17]  L. Schraiber,et al.  O homem na atenção primária à saúde: discutindo (in)visibilidade a partir da perspectiva de gênero , 2010 .

[18]  J. Lipozenčić,et al.  The frequency of superficial mycoses according to agents isolated during a ten-year period (1999-2008) in Zagreb area, Croatia. , 2010, Acta dermatovenerologica Croatica : ADC.

[19]  A. J. Carrillo-Muñoz,et al.  [Antifungal agents for onychomycoses]. , 2010, Revista iberoamericana de micologia.

[20]  H. Trau,et al.  Ciclopirox nail lacquer for the treatment of onychomycosis: An open non‐comparative study , 2010, The Journal of dermatology.

[21]  J. Hernández-Molina,et al.  [Antifungal agents for onychomycoses]. , 2010, Revista iberoamericana de micologia.

[22]  I. Biswas,et al.  Studies on comparison of the efficacy of terbinafine 1% cream and butenafine 1% cream for the treatment of Tinea cruris , 2010, Indian Dermatology Online Journal.

[23]  N. Martinez-Rossi,et al.  Dermatophytes: host-pathogen interaction and antifungal resistance. , 2010, Anais brasileiros de dermatologia.

[24]  M. Friedrich,et al.  Epidemiological trends in skin mycoses worldwide , 2008, Mycoses.

[25]  M. Andrews,et al.  Common tinea infections in children. , 2008, American family physician.

[26]  Aditya K. Gupta,et al.  Update in Antifungal Therapy of Dermatophytosis , 2008, Mycopathologia.

[27]  H. Degreef Clinical Forms of Dermatophytosis (Ringworm Infection) , 2008, Mycopathologia.

[28]  J. Bouchara,et al.  Updates on the Epidemiology of Dermatophyte Infections , 2008, Mycopathologia.

[29]  R. Kaur,et al.  Onychomycosis--epidemiology, diagnosis and management. , 2008, Indian journal of medical microbiology.

[30]  R. Arenas,et al.  Tiña de la cabeza , 2008 .

[31]  M. Friedrich,et al.  Title:Epidemiological trends in skin mycoses worldwide. , 2008 .

[32]  Patricia Manzano-Gayosso,et al.  La resistencia a los antifúngicos: un problema emergente en México , 2008 .

[33]  A. Singal Butenafine and superficial mycoses: current status. , 2008, Expert opinion on drug metabolism & toxicology.

[34]  T. I. E. Svidzinski,et al.  Dermatomicoses: freqüência, diagnóstico laboratorial e adesão de pacientes ao tratamento em um sistema público de saúde, Maringá-PR, Brasil , 2007 .

[35]  José Augusto de Oliveira,et al.  Micoses superficiais na cidade de Manaus, AM, entre março e novembro/2003 , 2006 .

[36]  S. Esmat,et al.  Efficacy of topical griseofulvin in treatment of tinea corporis , 2006, Mycoses.

[37]  E. R. Siqueira,et al.  [Occurrence of dermatophyte, in nails, feet and hands of university students]. , 2006, Revista da Sociedade Brasileira de Medicina Tropical.

[38]  Carlos César Somenzi,et al.  Características Particulares da Micologia Clínica e o Diagnóstico Laboratorial de Micoses Superficiais , 2006 .

[39]  F. Crawford,et al.  Fungal nail infections. , 2005, Clinical evidence.

[40]  L. Saxinger,et al.  Dermacase. Dermatophyte infection (tinea). , 2005, Canadian family physician Medecin de famille canadien.

[41]  L. Zaror,et al.  Fusarium Nail and Skin Infection: A Report of Eight Cases from Natal, Brazil , 2005, Mycopathologia.

[42]  M. Souza,et al.  Onicomicoses por fungos emergentes: anlise clnica, diagnstico laboratorial e reviso , 2003 .

[43]  J. Guarro,et al.  Collaborative Evaluation of Optimal Antifungal Susceptibility Testing Conditions for Dermatophytes , 2002, Journal of Clinical Microbiology.

[44]  S. Bell-Syer,et al.  Oral treatments for fungal infections of the skin of the foot. , 2002, The Cochrane database of systematic reviews.

[45]  G. Paixão,et al.  Epidemiologia e ecologia das dermatofitoses na cidade de Fortaleza: o Trichophyton tonsurans como importante patógeno emergente da Tinea capitis , 2000 .

[46]  J. Sidrim,et al.  [Epidemiology and ecology of dermatophytoses in the City of Fortaleza: Trichophyton tonsurans as important emerging pathogen of Tinea capitis]. , 2000, Revista da Sociedade Brasileira de Medicina Tropical.

[47]  Brum,et al.  A ten-year survey of onychomycosis in the central region of the rio grande do sul, brazil , 1999, Revista do Instituto de Medicina Tropical de Sao Paulo.

[48]  R. Kramer,et al.  Studies in Comparison , 1989 .