Stained images of Brodmann's area 45 in the left and right hemispheres of a human brain. Sections were stained using a modified Gallyas stain for Nissl

The human brain shows marked gross anatomical and microstructural asymmetries that are presumably related to lateralized motor and cognitive functions. This chapter generally summarizes the extant data on gross morphological asymmetries in human and nonhuman mammal brains. In addition, the evidence of microstructural asymmetries, such as gray-level index, minicolumn width, and cellular organization, are presented. Although there are few studies of microstructrual asymmetries in nonhuman primates, it is argued that such studies are important for validating morphological asymmetries as well as for understanding the cellular basis for hemispheric specialization in primates,

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