The respiratory depressant effects of mitragynine are limited by its conversion to 7‐OH mitragynine
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J. R. Lane | J. Javitch | M. Canals | A. Kruegel | Rob Hill | Andrew C. Kruegel | R. Hill | Meritxell Canals
[1] Samuel T. Slocum,et al. Oxidative Metabolism as a Modulator of Kratom's Biological Actions. , 2021, Journal of medicinal chemistry.
[2] Stephen P. H. Alexander,et al. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors , 2021, British journal of pharmacology.
[3] Stephen P. H. Alexander,et al. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes , 2021, British journal of pharmacology.
[4] C. Müller,et al. Methadone, Buprenorphine, and Clonidine Attenuate Mitragynine Withdrawal in Rats , 2021, Frontiers in Pharmacology.
[5] G. Pasternak,et al. Kratom Alkaloids as Probes for Opioid Receptor Function: Pharmacological Characterization of Minor Indole and Oxindole Alkaloids from Kratom. , 2021, ACS chemical neuroscience.
[6] Junmei Wang,et al. Drug-Drug Interaction Between Oxycodone and Diazepam by a Combined in Silico Pharmacokinetic and Pharmacodynamic Modeling Approach. , 2021, ACS chemical neuroscience.
[7] Elyssa B. Margolis,et al. A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects , 2021, bioRxiv.
[8] S. Sadhasivam,et al. Pharmacogenomics of oxycodone: a narrative literature review. , 2021, Pharmacogenomics.
[9] K. Sangkuhl,et al. Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy , 2021, Clinical pharmacology and therapeutics.
[10] J. Javitch,et al. Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy , 2020, Nature communications.
[11] P. Law,et al. Oxycodone in the Opioid Epidemic: High ‘Liking’, ‘Wanting’, and Abuse Liability , 2020, Cellular and Molecular Neurobiology.
[12] H. Raja,et al. Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions , 2020, Scientific Reports.
[13] Astrid G. Stucke,et al. Multi-Level Regulation of Opioid-Induced Respiratory Depression. , 2020, Physiology.
[14] B. Avery,et al. Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy. , 2020, ACS pharmacology & translational science.
[15] Christopher H George,et al. ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020 , 2020, British journal of pharmacology.
[16] Ulrich Dirnagl,et al. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research* , 2020, BMC Veterinary Research.
[17] Justin O. Brower,et al. Identification of five mitragyna alkaloids in blood and tissues using liquid chromatography-quadrupole/time-of-flight mass spectrometry , 2020, Forensic Toxicology.
[18] E. Levitt,et al. Kölliker-Fuse/Parabrachial complex mu opioid receptors contribute to fentanyl-induced apnea and respiratory rate depression , 2020, Respiratory Physiology & Neurobiology.
[19] V. Rinne,et al. Physiologically based pharmacokinetic modelling of oxycodone drug-drug interactions. , 2020, Biopharmaceutics & drug disposition.
[20] Jack Durell,et al. National Institute on Drug Abuse , 2020, Definitions.
[21] G. Pasternak,et al. G protein‐biased kratom‐alkaloids and synthetic carfentanil‐amide opioids as potential treatments for alcohol use disorder , 2019, British journal of pharmacology.
[22] O. Grundmann,et al. Current perspectives on the impact of Kratom use , 2019, Substance abuse and rehabilitation.
[23] G. Pasternak,et al. 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects , 2019, ACS central science.
[24] Bin Zhou,et al. Lateral Flow Assessment and Unanticipated Toxicity of Kratom. , 2018, Chemical research in toxicology.
[25] S. Husbands,et al. The novel μ‐opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception , 2018, British journal of pharmacology.
[26] S. Nielsen,et al. Identifying and treating codeine dependence: a systematic review , 2018, The Medical journal of Australia.
[27] O. Grundmann. Patterns of Kratom use and health impact in the US-Results from an online survey. , 2017, Drug and alcohol dependence.
[28] G. Pasternak,et al. Rubsicolins are naturally occurring G-protein-biased delta opioid receptor peptides , 2018, bioRxiv.
[29] S. Narayanan,et al. Traditional and non-traditional uses of Mitragynine (Kratom): A survey of the literature , 2016, Brain Research Bulletin.
[30] C. Müller,et al. Neurobiology of Kratom and its main alkaloid mitragynine , 2016, Brain Research Bulletin.
[31] J. Javitch,et al. Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators. , 2016, Journal of the American Chemical Society.
[32] Lydia M. M. Vermeer,et al. Evaluation of Ketoconazole and Its Alternative Clinical CYP3A4/5 Inhibitors as Inhibitors of Drug Transporters: The In Vitro Effects of Ketoconazole, Ritonavir, Clarithromycin, and Itraconazole on 13 Clinically-Relevant Drug Transporters , 2016, Drug Metabolism and Disposition.
[33] H. Dringenberg,et al. Abuse potential and adverse cognitive effects of mitragynine (kratom) , 2016, Addiction biology.
[34] Sarah L. Withey,et al. Ethanol Reversal of Tolerance to the Respiratory Depressant Effects of Morphine , 2015, Neuropsychopharmacology.
[35] Z. Walsh,et al. Experiences of Kratom Users: A Qualitative Analysis , 2015, Journal of psychoactive drugs.
[36] Paul A Insel,et al. Experimental design and analysis and their reporting: new guidance for publication in BJP , 2015, British journal of pharmacology.
[37] E. Plise,et al. Differential Effects of Rifampin and Ketoconazole on the Blood and Liver Concentration of Atorvastatin in Wild-Type and Cyp3a and Oatp1a/b Knockout Mice , 2014, Drug Metabolism and Disposition.
[38] V. Navaratnam,et al. Dose–Response Relationship, Acute Toxicity, and Therapeutic Index between the Alkaloid Extract of Mitragyna speciosa and Its Main Active Compound Mitragynine in Mice , 2013 .
[39] S. Haertter. Recent examples on the clinical relevance of the CYP2D6 polymorphism and endogenous functionality of CYP2D6 , 2013, Drug metabolism and drug interactions.
[40] J. Gudin. Opioid therapies and cytochrome p450 interactions. , 2012, Journal of pain and symptom management.
[41] Walter C. Prozialeck,et al. Pharmacology of Kratom: An Emerging Botanical Agent With Stimulant, Analgesic and Opioid-Like Effects , 2012, The Journal of the American Osteopathic Association.
[42] S. Fakurazi,et al. Antinociceptive Action of Isolated Mitragynine from Mitragyna Speciosa through Activation of Opioid Receptor System , 2012, International journal of molecular sciences.
[43] E. Boyer,et al. Mitragyna speciosa, a psychoactive tree from Southeast Asia with opioid activity. , 2011, Current topics in medicinal chemistry.
[44] S. Zoghbi,et al. Effects of ketoconazole on the biodistribution and metabolism of [11C]loperamide and [11C]N-desmethyl-loperamide in wild-type and P-gp knockout mice. , 2010, Nuclear medicine and biology.
[45] Howard S. Smith,et al. Opioid metabolism. , 2009, Mayo Clinic proceedings.
[46] J. Zadina,et al. Reduced suppression of CO2-induced ventilatory stimulation by endomorphins relative to morphine , 2005, Brain Research.
[47] H. Takayama. Chemistry and pharmacology of analgesic indole alkaloids from the rubiaceous plant, Mitragyna speciosa. , 2004, Chemical & pharmaceutical bulletin.
[48] H. Takayama,et al. Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa. , 2004, Life sciences.
[49] S. Darke. Polydrug use and overdose: overthrowing old myths. , 2003, Addiction.
[50] D. Back,et al. Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes. , 1998, British journal of clinical pharmacology.
[51] Shin-ichiro Sakai,et al. Antinociceptive action of mitragynine in mice: evidence for the involvement of supraspinal opioid receptors. , 1996, Life sciences.
[52] J. Weisbach,et al. Some observations on the pharmacology of mitragynine. , 1972, Archives internationales de pharmacodynamie et de therapie.