Superoxide from NADPH oxidase upregulates type 5 phosphodiesterase in human vascular smooth muscle cells: inhibition with iloprost and NONOate

[1]  K. Chorneyko,et al.  RhoA/Rho-Kinase Contribute to the Pathogenesis of Diabetic Renal Disease , 2008, Diabetes.

[2]  G. Angelini,et al.  Acute inhibition of superoxide formation and Rac1 activation by nitric oxide and iloprost in human vascular smooth muscle cells in response to the thromboxane A2 analogue, U46619. , 2008, Prostaglandins, leukotrienes, and essential fatty acids.

[3]  G. Angelini,et al.  Reactive oxygen species and erectile dysfunction: possible role of NADPH oxidase , 2007, International Journal of Impotence Research.

[4]  G. Angelini,et al.  Superoxide auto-augments superoxide formation and upregulates gp91(phox) expression in porcine pulmonary artery endothelial cells: inhibition by iloprost. , 2006, European journal of pharmacology.

[5]  Mark A Sussman,et al.  The Rac and Rho Hall of Fame: A Decade of Hypertrophic Signaling Hits , 2006, Circulation research.

[6]  P. Hordijk Regulation of NADPH Oxidases: The Role of Rac Proteins , 2006, Circulation research.

[7]  J. Jeremy,et al.  Nicotinamide adenine dinucleotide phosphate oxidase: a promiscuous therapeutic target for cardiovascular drugs? , 2005, Trends in cardiovascular medicine.

[8]  G. Angelini,et al.  The potential use of type-5 phosphodiesterase inhibitors in coronary artery bypass graft surgery. , 2005, Chest.

[9]  G. Angelini,et al.  Sildenafil citrate and sildenafil nitrate (NCX 911) are potent inhibitors of superoxide formation and gp91phox expression in porcine pulmonary artery endothelial cells , 2005, British journal of pharmacology.

[10]  G. Angelini,et al.  Acute hypoxia simultaneously induces the expression of gp91phox and endothelial nitric oxide synthase in the porcine pulmonary artery , 2005, Thorax.

[11]  A. Shah,et al.  Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. , 2004, American journal of physiology. Regulatory, integrative and comparative physiology.

[12]  Z. Ying,et al.  Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta. , 2004, American journal of physiology. Heart and circulatory physiology.

[13]  J. Liao,et al.  Inhibition of Rho-Kinase Leads to Rapid Activation of Phosphatidylinositol 3-Kinase/Protein Kinase Akt and Cardiovascular Protection , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[14]  G. Angelini,et al.  Nitroaspirins and Morpholinosydnonimine but Not Aspirin Inhibit the Formation of Superoxide and the Expression of gp91phox Induced by Endotoxin and Cytokines in Pig Pulmonary Artery Vascular Smooth Muscle Cells and Endothelial Cells , 2004, Circulation.

[15]  P. Pasricha,et al.  Modulation of TRPV1 by nonreceptor tyrosine kinase, c-Src kinase. , 2004, American journal of physiology. Cell physiology.

[16]  G. Angelini,et al.  Reactive oxygen species, vascular disease and cardiovascular surgery. , 2004, Current vascular pharmacology.

[17]  D. Hartshorne,et al.  Myosin phosphatase: Structure, regulation and function , 2004, Molecular and Cellular Biochemistry.

[18]  G. Angelini,et al.  Iloprost inhibits superoxide formation and gp91phox expression induced by the thromboxane A2 analogue U46619, 8‐isoprostane F2α, prostaglandin F2α, cytokines and endotoxin in the pig pulmonary artery , 2004, British journal of pharmacology.

[19]  Hisham S. Elbatarny,et al.  Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system. , 2003, Molecular pharmacology.

[20]  D. Harrison,et al.  The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases. , 2003, Trends in pharmacological sciences.

[21]  J. Beavo,et al.  Regulation of Nitric Oxide–Sensitive Guanylyl Cyclase Cyclic GMP Phosphodiesterases and Regulation of Smooth Muscle Function Structure, Regulation, and Function of Membrane Guanylyl Cyclase Receptors, With a Focus on GC-A Cyclic GMP–Dependent Protein Kinases and the Cardiovascular System: Insights F , 2003 .

[22]  A. Friebe,et al.  This Review Is Part of a Thematic Series on Cyclic Gmp–generating Enzymes and Cyclic Gmp–dependent Signaling, Which Includes the following Articles: Regulation of Nitric Oxide–sensitive Guanylyl Cyclase Cyclic Gmp Phosphodiesterases and Regulation of Smooth Muscle Function Structure, Regulation, and , 2022 .

[23]  G. Angelini,et al.  Role of the endothelium and nitric oxide synthases in modulating superoxide formation induced by endotoxin and cytokines in porcine pulmonary arteries , 2003, Thorax.

[24]  K. Kaibuchi,et al.  Rho GTPase/Rho Kinase Negatively Regulates Endothelial Nitric Oxide Synthase Phosphorylation through the Inhibition of Protein Kinase B/Akt in Human Endothelial Cells , 2002, Molecular and Cellular Biology.

[25]  H. Shimokawa,et al.  Rho-Kinase Mediates Hypoxia-Induced Downregulation of Endothelial Nitric Oxide Synthase , 2002, Circulation.

[26]  K. Kaibuchi,et al.  Elongation Factor-1α Is a Novel Substrate of Rho-Associated Kinase , 2000 .

[27]  D. Harrison,et al.  Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. , 2000, Circulation research.

[28]  D. Sorescu,et al.  Modulation of Protein Kinase Activity and Gene Expression by Reactive Oxygen Species and Their Role in Vascular Physiology and Pathophysiology , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[29]  A. Newby,et al.  Nitric oxide and the proliferation of vascular smooth muscle cells. , 1999, Cardiovascular research.

[30]  M. Sakurai,et al.  Phosphorylation of Vimentin by Rho-associated Kinase at a Unique Amino-terminal Site That Is Specifically Phosphorylated during Cytokinesis* , 1998, The Journal of Biological Chemistry.

[31]  Y. Agazie,et al.  A Rho-associated Protein Kinase, ROKα, Binds Insulin Receptor Substrate-1 and Modulates Insulin Signaling* , 1998, The Journal of Biological Chemistry.

[32]  J. Stolk,et al.  Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. , 1994, American journal of respiratory cell and molecular biology.

[33]  G. A. Thompson,et al.  Membrane formation in Tetrahymena pyriformis. 4. Lipid composition and biochemical properties of Tetrahymena pyriformis membrane systems , 1971 .

[34]  Thompson Wj,et al.  Multiple cyclic nucleotide phosphodiesterase activities from rat brain , 1971 .

[35]  K. Kaibuchi,et al.  Elongation factor-1 alpha is a novel substrate of rho-associated kinase. , 2000, Biochemical and biophysical research communications.

[36]  E. Miyamoto,et al.  Multiple cyclic nucleotide phosphodiesterase activities from rat tissues and occurrence of a calcium-plus-magnesium-ion-dependent phosphodiesterase and its protein activator. , 1975, The Biochemical journal.

[37]  M. M. Appleman,et al.  Multiple cyclic nucleotide phosphodiesterase activities from rat brain. , 1971, Biochemistry.