DNA damage and mutation: contributors to the age-related alterations in T cell-mediated immune responses?

[1]  L. Breimer Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: The role of dna base damage , 2006, Molecular carcinogenesis.

[2]  E. S. Gillespie,et al.  In vivo antioxidant status, DNA damage, mutation and DNA repair capacity in cultured lymphocytes from healthy 75- to 80-year-old humans. , 1997, Mutation research.

[3]  G. Pawelec,et al.  The T cell in the ageing individual 1 This article is based on a presentation to the First International Conference on Aging and Immunology, Bethesda, MD, 16–19 June, 1996. 1 , 1997, Mechanisms of Ageing and Development.

[4]  L. Rink,et al.  Dysregulation between TH1 and TH2 T cell subpopulations in the elderly , 1996, Mechanisms of Ageing and Development.

[5]  A. Fornace,et al.  Mammalian DNA damage-inducible genes associated with growth arrest and apoptosis. , 1996, Mutation research.

[6]  R. Effros Insights on immunological aging derived from the T lymphocyte cellular senescence model , 1996, Experimental Gerontology.

[7]  R. Paules,et al.  DNA damage and cell cycle checkpoints , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[8]  Y. Barnett,et al.  An investigation of antioxidant status, DNA repair capacity and mutation as a function of age in humans. , 1995, Mutation research.

[9]  A. McLean,et al.  In vivo estimates of division and death rates of human T lymphocytes. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[10]  L. Hartwell,et al.  Cell cycle control and cancer. , 1994, Science.

[11]  R. Effros,et al.  Decline in CD28+ T cells in centenarians and in long-term T cell cultures: A possible cause for both in vivo and in vitro immunosenescence , 1994, Experimental Gerontology.

[12]  E. S. Gillespie,et al.  An investigation of mutation as a function of age in humans. , 1994, Mutation research.

[13]  B. Ames,et al.  Oxidants, antioxidants, and the degenerative diseases of aging. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[14]  T. Lindahl Instability and decay of the primary structure of DNA , 1993, Nature.

[15]  R. Simmons,et al.  Reactive nitrogen intermediates suppress the primary immunologic response to Listeria. , 1993, Journal of immunology.

[16]  K. Kinzler,et al.  The multistep nature of cancer. , 1993, Trends in genetics : TIG.

[17]  D. Longo,et al.  Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin‐1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[18]  Bunker Vw Free radicals, antioxidants and ageing. , 1992 .

[19]  A. McLean,et al.  Lifespan of human lymphocyte subsets defined by CD45 isoforms , 1992, Nature.

[20]  C B Harley,et al.  Telomere length predicts replicative capacity of human fibroblasts. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[21]  C. Franceschi,et al.  Genomic Instability and Aging , 1992 .

[22]  A. Zwinderman,et al.  Use of the clonal assay for the measurement of frequencies of HPRT mutants in T-lymphocytes from five control populations. , 1991, Mutation research.

[23]  C. Franceschi,et al.  Aging, Longevity, and Cancer: Studies in Down's Syndrome and Centenarians a , 1991, Annals of the New York Academy of Sciences.

[24]  Veikko Hayatsu Mutagens in Food Detection and Prevention , 1991 .

[25]  W. Dröge,et al.  Interleukin-2 mRNA expression, lymphokine production and DNA synthesis in glutathione-depleted T cells. , 1990, Cellular immunology.

[26]  C. Harley,et al.  Telomeres shorten during ageing of human fibroblasts , 1990, Nature.

[27]  D. Goeddel,et al.  Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism , 1988, Science.

[28]  E. Mullaart,et al.  Age-dependent accumulation of alkali-labile sites in DNA of post-mitotic but not in that of mitotic rat liver cells , 1988, Mechanisms of Ageing and Development.

[29]  M. Green,et al.  A further assessment of factors influencing measurements of thioguanine-resistant mutant frequency in circulating T-lymphocytes. , 1988, Mutation research.

[30]  Y. Nakatsuru,et al.  Carcinogenic effect of the simultaneous administration of five heterocyclic amines to F344 rats. , 1987, Japanese journal of cancer research : Gann.

[31]  T. Makinodan,et al.  Frequency of 6-thioguanine-resistant T cells is inversely related to the declining T-cell activities in aging mice. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[32]  Kevin J. Trainor,et al.  Mutation frequency in human lymphocytes increases with age , 1984, Mechanisms of Ageing and Development.

[33]  A. Morley,et al.  Human lymphocytes resistant to 6-thioguanine increase with age , 1982, Mechanisms of Ageing and Development.

[34]  J. Oppenheim,et al.  Macrophage-mediated suppression. I. Evidence for participation of both hdyrogen peroxide and prostaglandins in suppression of murine lymphocyte proliferation. , 1980, Journal of immunology.

[35]  L. Hayflick,et al.  The serial cultivation of human diploid cell strains. , 1961, Experimental cell research.

[36]  B. Lambert,et al.  Reduced proliferation rate of hypoxanthine‐phosphoribosyl transferase mutant human T‐lymphocytes in vitro , 1996, Environmental and molecular mutagenesis.

[37]  C. Franceschi,et al.  The immunology of exceptional individuals: the lesson of centenarians. , 1995, Immunology today.

[38]  T. Buttke,et al.  Oxidative stress as a mediator of apoptosis. , 1994, Immunology today.

[39]  I Hannet,et al.  Developmental and maturational changes in human blood lymphocyte subpopulations. , 1992, Immunology today.

[40]  R. Tice,et al.  Basal DNA damage in individual human lymphocytes with age. , 1991, Mutation research.

[41]  D. Beare,et al.  Hprt mutant frequencies in circulating lymphocytes: population studies using normal donors, exposed groups and cancer-prone syndromes. , 1991, Progress in clinical and biological research.

[42]  K. Davies,et al.  Protein, lipid and DNA repair systems in oxidative stress: the free-radical theory of aging revisited. , 1991, Gerontology.

[43]  T. Sugimura,et al.  Successful use of short-term tests for academic purposes: their use in identification of new environmental carcinogens with possible risk for humans. , 1988, Mutation research.

[44]  N. Berger Poly(ADP-ribose) in the cellular response to DNA damage. , 1985, Radiation research.

[45]  M. Fenech,et al.  The effect of donor age on spontaneous and induced micronuclei. , 1985, Mutation research.

[46]  Vijayalaxmi,et al.  Measurement of spontaneous and X-irradiation-induced 6-thioguanine-resistant human blood lymphocytes using a T-cell cloning technique. , 1984, Mutation research.

[47]  P. Lipsky,et al.  Immunosuppression by D-penicillamine in vitro. Inhibition of human T lymphocyte proliferation by copper- or ceruloplasmin-dependent generation of hydrogen peroxide and protection by monocytes. , 1984, The Journal of clinical investigation.