Engineered Tet repressors with recognition specificity for the tetO-4C5G operator variant.
暂无分享,去创建一个
[1] Wolfgang Hillen,et al. Gene regulation by tetracyclines. , 2004, Genetic engineering.
[2] Single-chain Tet transregulators. , 2003, Nucleic acids research.
[3] A. Jeltsch,et al. Recognition and cleavage of DNA by type-II restriction endonucleases. , 1997, European journal of biochemistry.
[4] J. Richardson,et al. Amino acid preferences for specific locations at the ends of alpha helices. , 1988, Science.
[5] M. Gossen,et al. Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[6] M. T. Hasan,et al. Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[7] M. Gossen,et al. Tetracyclines in the control of gene expression in eukaryotes , 2001 .
[8] Ralph Bertram,et al. Activity reversal of Tet repressor caused by single amino acid exchanges , 2004, Molecular microbiology.
[9] J. S. Kim,et al. Zinc Finger Proteins as Designer Transcription Factors* , 2000, The Journal of Biological Chemistry.
[10] W. Hillen,et al. Amino acids determining operator binding specificity in the helix‐turn‐helix motif of Tn10 Tet repressor. , 1991, The EMBO journal.
[11] Alfonso Mondragón,et al. The phage 434 Cro/OR1 complex at 2.5 A resolution. , 1991, Journal of molecular biology.
[12] W. Hillen,et al. Selection for Tn10 tet repressor binding to tet operator in Escherichia coli: isolation of temperature-sensitive mutants and combinatorial mutagenesis in the DNA binding motif. , 1991, Genetics.
[13] W. Hillen,et al. Tetracyclines in Biology, Chemistry and Medicine , 2001, Birkhäuser Basel.
[14] W. Hillen,et al. Teaching TetR to recognize a new inducer. , 2003, Journal of molecular biology.
[15] Jeffrey H. Miller. Experiments in molecular genetics , 1972 .
[16] W. Hillen,et al. Contacts between Tet repressor and tet operator revealed by new recognition specificities of single amino acid replacement mutants. , 1992, Journal of molecular biology.
[17] S. Harrison,et al. The phage 434 OR2/R1-69 complex at 2.5 A resolution. , 1993, Journal of molecular biology.
[18] W. Hillen,et al. Induction of single chain tetracycline repressor requires the binding of two inducers , 2006, Nucleic acids research.
[19] J. Sambrook,et al. Molecular Cloning: A Laboratory Manual , 2001 .
[20] Pascale Cossart,et al. Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli , 1984, Nature.
[21] B. Müller-Hill,et al. Mutants in position 69 of the Trp repressor ofEscherichia coli K12 with altered DNA-binding specificity , 1996, Molecular and General Genetics MGG.
[22] W. Hillen,et al. Generating Tetracycline-Inducible Auxotrophy in Escherichia coli and Salmonella enterica Serovar Typhimurium by Using an Insertion Element and a Hyperactive Transposase , 2006, Applied and Environmental Microbiology.
[23] W. Hillen,et al. Stepwise selection of TetR variants recognizing tet operator 4C with high affinity and specificity. , 1998, Journal of molecular biology.
[24] A. C. Chang,et al. Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid , 1978, Journal of bacteriology.
[25] W. Hillen,et al. Determinants of protein–protein recognition by four helix bundles: changing the dimerization specificity of Tet repressor , 1998, The EMBO journal.
[26] Independent Regulation of Two Genes in Escherichia coli by Tetracyclines and Tet Repressor Variants , 2004, Journal of bacteriology.
[27] W. Saenger,et al. Structural basis of gene regulation by the tetracycline inducible Tet repressor–operator system , 2000, Nature Structural Biology.
[28] Transactivator mutants with altered effector specificity allow selective regulation of two genes by tetracycline variants. , 2004, Gene.
[29] D. Hanahan. Studies on transformation of Escherichia coli with plasmids. , 1983, Journal of molecular biology.
[30] W. Hillen,et al. Two mutations in the tetracycline repressor change the inducer anhydrotetracycline to a corepressor. , 2004, Nucleic acids research.
[31] Alan R Davidson,et al. Two-way interdomain signal transduction in tetracycline repressor. , 2006, Journal of molecular biology.
[32] W. Hillen,et al. Combinations of the alpha-helix-turn-alpha-helix motif of TetR with respective residues from LacI or 434Cro: DNA recognition, inducer binding, and urea-dependent denaturation. , 1997, Biochemistry.
[33] M. Gossen,et al. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[34] W. Hillen,et al. Quantitative analysis of Tn10 Tet repressor binding to a complete set of tet operator mutants. , 1990, Nucleic acids research.