Symmetry-based HIV Protease inhibitors: rational design of 2-methylbenzamides as novel P2/P2′ ligands

[1]  K. Appelt,et al.  Structure-based drug design of nonpeptidic P2 substituents for HIV-1 protease inhibitors , 1995 .

[2]  A. Haight,et al.  An Efficient Stereocontrolled Strategy for the Synthesis of Hydroxyethylene Dipeptide Isosteres , 1994 .

[3]  S. Kaldor,et al.  New dipeptide isosteres useful for the inhibition of HIV-1 protease , 1994 .

[4]  Dale J. Kempf,et al.  Influence of Stereochemistry on Activity and Binding Modes for C2 Symmetry-Based Diol Inhibitors of HIV-1 Protease , 1994 .

[5]  S. Vasavanonda,et al.  Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol. , 1993, Journal of medicinal chemistry.

[6]  D. Norbeck,et al.  Stereocontrolled synthesis of C2-symmetric and pseudo-C2-symmetric diamino alcohols and diols for use in HIV protease inhibitors , 1992 .

[7]  Roger E Bumgarner,et al.  Benzene Forms Hydrogen Bonds with Water , 1992, Science.

[8]  S. Vasavanonda,et al.  Antiviral and pharmacokinetic properties of C2 symmetric inhibitors of the human immunodeficiency virus type 1 protease , 1991, Antimicrobial Agents and Chemotherapy.

[9]  J. Huff,et al.  HIV protease: a novel chemotherapeutic target for AIDS. , 1991, Journal of medicinal chemistry.

[10]  S. Vasavanonda,et al.  Structure-based, C2 symmetric inhibitors of HIV protease. , 1990, Journal of medicinal chemistry.

[11]  D. Norbeck,et al.  Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease. , 1990, Science.

[12]  M. Jaskólski,et al.  Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease. , 1989, Science.

[13]  M. Navia,et al.  Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1 , 1989, Nature.

[14]  William R. Taylor,et al.  A structural model for the retroviral proteases , 1987, Nature.

[15]  A. Mcinnes,et al.  Influence of Lewis Acids on the Diels–Alder Reaction. VI. Reaction of 2,5-Dimethyl- and 2,5-Diphenylfuran with Ethyl Propiolate , 1971 .

[16]  M. Murcko,et al.  Crystal Structure of HIV-1 Protease in Complex with Vx-478, a Potent and Orally Bioavailable Inhibitor of the Enzyme , 1995 .