Delivering the kiss of death
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[1] P. Bird,et al. The Intracellular Granzyme B Inhibitor, Proteinase Inhibitor 9, Is Up-Regulated During Accessory Cell Maturation and Effector Cell Degranulation, and Its Overexpression Enhances CTL Potency1 , 2003, The Journal of Immunology.
[2] J. Lieberman,et al. Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A , 2003, Nature Immunology.
[3] P. Pandolfi,et al. The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells. , 2002, Immunity.
[4] R. Clementi,et al. Haemophagocytic lymphohistiocytosis: proposal of a diagnostic algorithm based on perforin expression , 2002, British journal of haematology.
[5] M. McNiven,et al. Motoring around the Golgi , 2002, Nature Cell Biology.
[6] P. Henkart,et al. Surface Cathepsin B Protects Cytotoxic Lymphocytes from Self-destruction after Degranulation , 2002, Journal of Experimental Medicine.
[7] G. Griffiths. Albinism and immunity: what's the link? , 2002, Current molecular medicine.
[8] Alistair N. Hume,et al. A Family of Rab27-binding Proteins , 2002, The Journal of Biological Chemistry.
[9] J. Fournié,et al. Synaptic Transfer by Human γδ T Cells Stimulated with Soluble or Cellular Antigens1 , 2002, The Journal of Immunology.
[10] A. Fischer,et al. Functional consequences of perforin gene mutations in 22 patients with familial haemophagocytic lymphohistiocytosis , 2002, British journal of haematology.
[11] R. Bleackley,et al. Cytotoxic T lymphocytes: all roads lead to death , 2002, Nature Reviews Immunology.
[12] K. Mikoshiba,et al. Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. , 2002, Biochemical and biophysical research communications.
[13] E. Joly,et al. Active trans‐synaptic capture of membrane fragments by natural killer cells , 2002, European journal of immunology.
[14] J. Sellers,et al. Rab27a is an essential component of melanosome receptor for myosin Va. , 2002, Molecular biology of the cell.
[15] K. Mikoshiba,et al. Slac2-a/Melanophilin, the Missing Link between Rab27 and Myosin Va , 2002, The Journal of Biological Chemistry.
[16] H. Goodson,et al. Late endosome motility depends on lipids via the small GTPase Rab7 , 2002, The EMBO journal.
[17] Vladimir Gelfand. Faculty Opinions recommendation of Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. , 2002 .
[18] L. Collinson,et al. The leaden Gene Product Is Required with Rab27a to Recruit Myosin Va to Melanosomes in Melanocytes , 2002, Traffic.
[19] J. Trapani,et al. Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. , 2002, Immunity.
[20] H. Takada,et al. Perforin defects of primary haemophagocytic lymphohistiocytosis in Japan , 2002, British journal of haematology.
[21] J. Rothberg,et al. The Chediak-Higashi Protein Interacts with SNARE Complex and Signal Transduction Proteins , 2002, Molecular medicine.
[22] J. Fournié,et al. Synaptic transfer by human gamma delta T cells stimulated with soluble or cellular antigens. , 2002, Journal of immunology.
[23] P. A. van der Merwe. Formation and function of the immunological synapse. , 2002, Current opinion in immunology.
[24] M. Poenie,et al. Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing. , 2002, Immunity.
[25] K. Kärre,et al. Acquisition of External Major Histocompatibility Complex Class I Molecules by Natural Killer Cells Expressing Inhibitory Ly49 Receptors , 2001, The Journal of experimental medicine.
[26] Leo M. Carlin,et al. Intercellular Transfer and Supramolecular Organization of Human Leukocyte Antigen C at Inhibitory Natural Killer Cell Immune Synapses 〉 , 2001, The Journal of experimental medicine.
[27] J. Lieberman,et al. Granzyme A Activates an Endoplasmic Reticulum-associated Caspase-independent Nuclease to Induce Single-stranded DNA Nicks* , 2001, The Journal of Biological Chemistry.
[28] G. Griffiths,et al. The immunological synapse of CTL contains a secretory domain and membrane bridges. , 2001, Immunity.
[29] A. Zweifach,et al. Role of calcium influx in cytotoxic T lymphocyte lytic granule exocytosis during target cell killing. , 2001, Immunity.
[30] Jacques Neefjes,et al. The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors , 2001, Current Biology.
[31] G. de Saint Basile,et al. The role of cytotoxicity in lymphocyte homeostasis. , 2001, Current opinion in immunology.
[32] M. Neuberger,et al. B cells acquire antigen from target cells after synapse formation , 2001, Nature.
[33] E. Joly,et al. Cutting Edge: CTLs Rapidly Capture Membrane Fragments from Target Cells in a TCR Signaling-Dependent Manner1 , 2001, The Journal of Immunology.
[34] Marion E. Schneider,et al. Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis. , 2001, American journal of human genetics.
[35] L. Collinson,et al. Rab27a Regulates the Peripheral Distribution of Melanosomes in Melanocytes , 2001, Journal of Cell Biology.
[36] E. Haddad,et al. Defective Granule Exocytosis in Rab27a-Deficient Lymphocytes from Ashen Mice , 2001, The Journal of cell biology.
[37] L. Machesky,et al. Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes , 2001, The Journal of cell biology.
[38] E. G. Arias-Salgado,et al. A 1063G→A mutation in exon 12 of glycoprotein (GP)IIb associated with a thrombasthenic phenotype: mutation analysis of [324E]GPIIb , 2000, British journal of haematology.
[39] R. Zinkernagel,et al. On the pathogenesis of perforin defects and related immunodeficiencies. , 2000, Immunology today.
[40] G. Korbutt,et al. Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Is a Death Receptor for Granzyme B during Cytotoxic T Cell–Induced Apoptosis , 2000, Cell.
[41] J. Kaplan,et al. Analysis of the Lysosomal Storage Disease Chediak–Higashi Syndrome , 2000, Traffic.
[42] N. Copeland,et al. A mutation in Rab27a causes the vesicle transport defects observed in ashen mice. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[43] G. de Saint Basile,et al. Perforin: more than just an effector molecule. , 2000, Immunology today.
[44] A. Fischer,et al. Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome , 2000, Nature Genetics.
[45] L. Page,et al. Secretory Lysosome Biogenesis in Cytotoxic T Lymphocytes from Normal and Chediak Higashi Syndrome Patients , 2000, Traffic.
[46] S. Kingsmore,et al. Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[47] M. Jackson,et al. T Cells Can Use Either T Cell Receptor or Cd28 Receptors to Absorb and Internalize Cell Surface Molecules Derived from Antigen-Presenting Cells , 2000, The Journal of experimental medicine.
[48] A. Fischer,et al. Two genes are responsible for Griscelli syndrome at the same 15q21 locus. , 2000, Genomics.
[49] A. Fischer,et al. Perforin gene defects in familial hemophagocytic lymphohistiocytosis. , 1999, Science.
[50] J. Trapani,et al. Cytosolic Delivery of Granzyme B by Bacterial Toxins: Evidence that Endosomal Disruption, in Addition to Transmembrane Pore Formation, Is an Important Function of Perforin , 1999, Molecular and Cellular Biology.
[51] M. Jackson,et al. TCR-Mediated internalization of peptide-MHC complexes acquired by T cells. , 1999, Science.
[52] G. Griffiths,et al. Regulated Secretion from Hemopoietic Cells , 1999, The Journal of cell biology.
[53] T. Mak,et al. Homeostatic regulation of CD8+ T cells by perforin , 1999, European journal of immunology.
[54] R. Ahmed,et al. A Role for Perforin in Downregulating T-Cell Responses during Chronic Viral Infection , 1999, Journal of Virology.
[55] J. Tschopp,et al. FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation. , 1998, Journal of immunology.
[56] B. Goud,et al. Interaction of a Golgi-associated kinesin-like protein with Rab6. , 1998, Science.
[57] M. Zvelebil,et al. Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid‐binding C2 domain , 1997, The EMBO journal.
[58] D. Hudig,et al. Perforin-enhancing protein, a low molecular weight protein of cytotoxic lymphocyte granules, enhances perforin lysis. , 1997, Biochemical and biophysical research communications.
[59] R. Gottlieb,et al. New Paradigm for Lymphocyte Granule-mediated Cytotoxicity , 1996, The Journal of Biological Chemistry.
[60] M. Lovett,et al. Identification of the homologous beige and Chediak–Higashi syndrome genes , 1996, Nature.
[61] M. Justice,et al. Identification of the murine beige gene by YAC complementation and positional cloning , 1996, Nature Genetics.
[62] R. Zinkernagel,et al. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. , 1996, Annual review of immunology.
[63] K. Baetz,et al. Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis. , 1995, Journal of immunology.
[64] P. Henkart,et al. Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin , 1995, Journal of Experimental Medicine.
[65] M. Peitsch,et al. Perforin and granzymes: crucial effector molecules in cytolytic T lymphocyte and natural killer cell-mediated cytotoxicity. , 1995, Current topics in microbiology and immunology.
[66] R. Ueda,et al. Immune function in mice lacking the perforin gene. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[67] J. Tschopp,et al. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways , 1994, Nature.
[68] Timothy J. Ley,et al. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells , 1994, Cell.
[69] J. Shiver,et al. Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A , 1992, Cell.
[70] R. Aebersold,et al. A natural killer cell granule protein that induces DNA fragmentation and apoptosis , 1992, The Journal of experimental medicine.
[71] J. Slot,et al. Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes , 1991, The Journal of experimental medicine.
[72] J. Shiver,et al. A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene , 1991, Cell.
[73] J. Tschopp,et al. Functional size of complement and perforin pores compared by confocal laser scanning microscopy and fluorescence microphotolysis. , 1991, Biochimica et biophysica acta.
[74] Y. Argon,et al. The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments , 1990, The Journal of cell biology.
[75] H. Eisen,et al. Cognate peptides induce self-destruction of CD8+ cytolytic T lymphocytes. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[76] 真貝 洋一. Homology of perforin to the ninth component of complement (C9) , 1990 .
[77] P. Henkart,et al. Mechanism of lysis by large granular lymphocyte granule cytolysin: generation of a stable cytolysin-RBC intermediate. , 1989, Journal of immunology.
[78] J. Tschopp,et al. Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis , 1986, Nature.
[79] S. Singer,et al. On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell , 1986, The Journal of experimental medicine.
[80] J. D. Young,et al. Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[81] K. Figura,et al. Internalization of blocking antibodies against mannose‐6‐phosphate specific receptors. , 1985, The EMBO journal.
[82] S. Singer,et al. The reorientation of the Golgi apparatus and the microtubule-organizing center in the cytotoxic effector cell is a prerequisite in the lysis of bound target cells. , 1985, The Journal of molecular and cellular immunology : JMCI.
[83] A. Kupfer,et al. Reorientation of the microtubule-organizing center and the Golgi apparatus in cloned cytotoxic lymphocytes triggered by binding to lysable target cells. , 1984, Journal of immunology.
[84] Craig W. Reynolds,et al. Purification and properties of cytoplasmic granules from cytotoxic rat LGL tumors. , 1984, Journal of immunology.
[85] B. Geiger,et al. Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells , 1982, The Journal of cell biology.
[86] P. Henkart,et al. Lymphocyte mediated cytolysis as a secretory phenomenon. , 1982, Advances in experimental medicine and biology.
[87] J. Grubb,et al. Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling , 1980, The Journal of cell biology.
[88] C. Sanderson. The mechanism of T cell mediated cytotoxicity I. The release of different cell components , 1976, Proceedings of the Royal Society of London. Series B. Biological Sciences.