ACE DD genotype: an independent predisposition factor to venous thromboembolism

Background The renin angiotensin system affects haemostasis through different mechanisms; data on the possible role of angiotensin‐converting enzyme I/D polymorphism in the pathogenesis of deep venous thrombosis are conflicting, and no information is available regarding the A1166C polymorphism of the angiotensin type 1 receptor gene. In order to investigate this issue, angiotensin‐converting enzyme and AT1R polymorphisms were genotyped in 336 consecutive venous thromboembolism patients and 378 controls.

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