Optimal control of a batch bioreactor: a study on the use of an imperfect model

Abstract This paper presents a numerical study on the performance degradation of a batch bioreactor optimal control strategy when the model used to compute such strategy shows wide variations from the real process. The optimal control was computed using a model that, when exposed to large variations of the control inputs, presents large departures from real process behavior. An improved model based on published experiments was proposed. A new optimal policy was calculated and the behavior of this model when controlled with the earlier policy was studied. Although the earlier control showed a performance degradation with respect to the real optimal control, degradation was modest, and the results are superior to these obtained with other control strategies.

[1]  P. Sandford,et al.  Extracellular Microbial Polysaccharides , 1977 .

[2]  A. H. Evers Sensitivity analysis in dynamic optimization , 1980 .

[3]  Olga Georgieva,et al.  Modeling and control of batch fermentation processes under conditions of uncertainty , 1996 .

[4]  Shangtian Yang,et al.  Kinetics and modeling of temperature effects on batch xanthan gum fermentation , 1991, Biotechnology and bioengineering.

[5]  A Constantinides,et al.  Optimization of batch fermentation processes. II. Optimum temperature profiles for batch penicillin fermentations , 1970, Biotechnology and bioengineering.

[6]  C. Dussap,et al.  Modelling Xanthomonas campestris batch fermentations in a bubble column , 1989, Biotechnology and bioengineering.

[7]  M. Morari,et al.  Chemical process control-CPC III : Elsevier, Amsterdam, 1986 (ISBN 0-444-99532-3). xi + 932 pp. Price $153.25/Dfl. 345.00. , 1987 .

[8]  H. Maurer,et al.  Sensitivity analysis for parametric control problems with control-state constraints , 1994, Proceedings of 1994 33rd IEEE Conference on Decision and Control.

[9]  M. Nikolaou,et al.  Sensitivity analysis of optimal control policies for batch processes , 1990 .

[10]  Shangtian Yang,et al.  Effects of temperature on cell growth and xanthan production in batch cultures of Xanthomonas campestris , 1990, Biotechnology and bioengineering.

[11]  Dardo Marqués,et al.  Optimal control of a batch bioreactor for the production of xanthan gum , 2001 .

[12]  J-H Lee,et al.  Optimal pH control of batch processes for production of curdlan by Agrobacterium species , 1999, Journal of Industrial Microbiology and Biotechnology.

[13]  David F. Ollis,et al.  Extracellular microbial polysaccharides. I. Substrate, biomass, and product kinetic equations for batch xanthan gum fermentation , 1980 .