Quantitative Positron Emission Tomography Studies of the Serotonin Transporter in Humans Previously Treated with the Appetite Suppressants Fenfluramine or Dexfenfluramine

[1]  Robert B. Innis,et al.  Sex Differences in Diencephalon Serotonin Transporter Availability in Major Depression , 2006, Biological Psychiatry.

[2]  E. Colman.  Anorectics on Trial: A Half Century of Federal Regulation of Prescription Appetite Suppressants , 2005, Annals of Internal Medicine.

[3]  Zsolt Szabo,et al.  Quantitative PET Studies of the Serotonin Transporter in MDMA Users and Controls Using [11C]McN5652 and [11C]DASB , 2005, Neuropsychopharmacology.

[4]  Ralph Buchert,et al.  A voxel-based PET investigation of the long-term effects of "Ecstasy" consumption on brain serotonin transporters. , 2004, The American journal of psychiatry.

[5]  Zsolt Szabo,et al.  Positron emission tomography imaging of the serotonin transporter in subjects with a history of alcoholism , 2004, Biological Psychiatry.

[6]  Mark Slifstein,et al.  Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[7]  J. Hornung,et al.  The human raphe nuclei and the serotonergic system , 2003, Journal of Chemical Neuroanatomy.

[8]  M. Verbaten.  Specific memory deficits in ecstasy users? The results of a meta‐analysis , 2003, Human psychopharmacology.

[9]  Ralph Buchert,et al.  Long-term effects of "ecstasy" use on serotonin transporters of the brain investigated by PET. , 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[10]  John Hilton,et al.  Comparison of (+)-11C-McN5652 and 11C-DASB as Serotonin Transporter Radioligands Under Various Experimental Conditions , 2002 .

[11]  Zsolt Szabo,et al.  Modified Regression Model for the Logan Plot , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[12]  M Fujita,et al.  Sex differences in [123I]β‐CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers , 2001, Synapse.

[13]  S. Houle,et al.  Novel Radiotracers for Imaging the Serotonin Transporter by Positron Emission Tomography: Synthesis, Radiosynthesis, and in Vitro and ex Vivo Evaluation of (11)C-Labeled 2-(Phenylthio)araalkylamines. , 2000, Journal of medicinal chemistry.

[14]  D. Wong,et al.  Column-switching HPLC for the analysis of plasma in PET imaging studies. , 2000, Nuclear medicine and biology.

[15]  M. Kraut,et al.  Kinetic Analysis of [11C]McN5652: A Serotonin Transporter Radioligand , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[16]  Z. Szabo,et al.  Positron emission tomographic evidence of toxic effect of MDMA (“Ecstasy”) on brain serotonin neurons in human beings , 1998, The Lancet.

[17]  Z. Szabo,et al.  In vivo detection of short‐ and long‐term MDMA neurotoxicity—a positron emission tomography study in the living baboon brain , 1998, Synapse.

[18]  W. Edwards,et al.  Valvular heart disease associated with fenfluramine-phentermine. , 1997, The New England journal of medicine.

[19]  H. Preval,et al.  Psychotic episode associated with dexfenfluramine. , 1997, The American journal of psychiatry.

[20]  C. Raison,et al.  Psychotic mania associated with fenfluramine and phentermine use. , 1997, The American journal of psychiatry.

[21]  Z. Szabo,et al.  Fenfluramine‐induced loss of serotonin transporters in baboon brain visualized with PET , 1996, Synapse.

[22]  P. Dodd,et al.  The nature ofd,l-fenfluramine-induced 5-HT reuptake transporter loss in rats , 1995, Molecular Neurobiology.

[23]  H. Pijl,et al.  Major depression during dexfenfluramine treatment. , 1994, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[24]  U. McCann,et al.  Dexfenfluramine and serotonin neurotoxicity: further preclinical evidence that clinical caution is indicated. , 1994, The Journal of pharmacology and experimental therapeutics.

[25]  S. Garattini,et al.  The role of d-norfenfluramine in the indole-depleting effect of d-fenfluramine in the rat. , 1993, European journal of pharmacology.

[26]  Michael P. Johnson,et al.  Comparative serotonin neurotoxicity of the stereoisomers of fenfluramine and norfenfluramine , 1990, Pharmacology Biochemistry and Behavior.

[27]  J. Contrera,et al.  Effects of repeated fenfluramine administration on indices of monoamine function in rat brain: pharmacokinetic, dose response, regional specificity and time course data. , 1990, The Journal of pharmacology and experimental therapeutics.

[28]  M. Molliver,et al.  Anatomic evidence for a neurotoxic effect of (±)-fenfluramine upon serotonergic projections in the rat , 1990, Brain Research.

[29]  L. Seiden,et al.  D-, L- and DL-fenfluramine cause long-lasting depletions of serotonin in rat brain , 1989, Brain Research.

[30]  J. Contrera,et al.  Fenfluramine selectively and differentially decreases the density of serotonergic nerve terminals in rat brain: evidence from immunocytochemical studies. , 1989, The Journal of pharmacology and experimental therapeutics.

[31]  L. Seiden,et al.  Effect of depletion of brain serotonin by repeated fenfluramine on neurochemical and anorectic effects of acute fenfluramine. , 1988, The Journal of pharmacology and experimental therapeutics.

[32]  A. G. Zacchei,et al.  FENFLURAMINE AND BRAIN SEROTONIN , 1978, Annals of the New York Academy of Sciences.

[33]  J. Harvey,et al.  Comparison between the neurotoxic and serotonin-depleting effects of various halogenated derivatives of amphetamine in the rat. , 1977, The Journal of pharmacology and experimental therapeutics.

[34]  T. Harding.  Depression Following Fenfluramine Withdrawal , 1972, British Journal of Psychiatry.

[35]  T. Harding.  Fenfluramine dependence. , 1971, British medical journal.

[36]  M. Briggs,et al.  Drugs of Dependence Though Not of Abuse: Fenfluramine and Imipramine , 1971, British medical journal.

[37]  D. Hawks.  Unusual effect of fenfluramine. , 1970, British medical journal.

[38]  T. Darby.  On Division of the Stricture in Strangulated Hernia , 1868, British medical journal.

[39]  V. Arango,et al.  Serotonin brain circuits involved in major depression and suicide. , 2002, Progress in brain research.

[40]  John Hilton,et al.  Comparison of (+)-(11)C-McN5652 and (11)C-DASB as serotonin transporter radioligands under various experimental conditions. , 2002, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[41]  John Hilton,et al.  as Serotonin Transporter Radioligands Under Various Experimental Conditions , 2002 .

[42]  D. Murphy,et al.  Brain serotonin neurotransmission: an overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs. , 1998, The Journal of clinical psychiatry.

[43]  L. Seiden,et al.  Fenfluramine: neurotoxicity. , 1986, Psychopharmacology bulletin.

[44]  E. sanders-Bush,et al.  Long-term effects of p-chloroamphetamine and related drugs on central serotonergic mechanisms. , 1975, The Journal of pharmacology and experimental therapeutics.

[45]  Harvey Ja,et al.  Fenfluramine: evidence for a neurotoxic action on midbrain and a long-term depletion of serotonin. , 1975, Psychopharmacology communications.