Rearrangements of the retinotectal projection in Rana pipiens after unilateral caudal half‐tectum ablation

When the caudal half‐tectum is ablated aid the optic nerve is cut in adult Rana pipiens, recordings from optic nerve terminals show that the entire visual field comes to be represented in retinotopic ordcr on the reinairring rostral half‐tecturn (compression). In contrast, if the caudal half‐tectum is ablated but the optic nerve is left intact, no compression of the retinotectal projection results. Instead, the terminals displaced from the ablatcd tissue form apermanently disorganized projection to the rostral half‐tectum superimposed on the unaltered representation of those parts of the retinawhich normally project there. The receptive field locations of tectal ncurons in both groups of animals show that the altered retinotectal projections make functional synapses. This conclusion is further supported by hehavioral data. which show that the accuracy of prey‐catching movements is altered in both groups of frogs.

[1]  Ramón y Cajal,et al.  Histologie du système nerveux de l'homme & des vertébrés , 1909 .

[2]  Roger W. Sperry,et al.  OPTIC NERVE REGENERATION WITH RETURN OF VISION IN ANURANS , 1944 .

[3]  J. E. Rose,et al.  A metal-filled microelectrode. , 1953, Science.

[4]  R. Sperry,et al.  Preferential selection of central pathways by regenerating optic fibers. , 1963, Experimental neurology.

[5]  R. M. Gaze,et al.  Selection of appropriate tectal connections by regenerating optic nerve fibers in adult goldfish. , 1965, Experimental neurology.

[6]  H. Knapp,et al.  New Observations on the Retinal Projection in the Frog , 1968 .

[7]  K. Fite,et al.  Single-unit analysis of binocular neurons in the frog optic tectum. , 1969, Experimental neurology.

[8]  D. Ingle,et al.  Visuomotor functions of the frog optic tectum. , 1970, Brain, behavior and evolution.

[9]  R. M. Gaze,et al.  The retinotopic organization of visual responses from tectal reimplants in adult goldfish. , 1971, Archives italiennes de biologie.

[10]  M. Yoon.  Reorganization of retinotectal projection following surgical operations on the optic tectum in goldfish. , 1971, Experimental neurology.

[11]  H. D. Potter.  Terminal arborizations of retinotectal axons in the bullfrog , 1972, The Journal of comparative neurology.

[12]  S. Sharma.  Redistribution of visual projections in altered optic tecta of adult goldfish. , 1972, Proceedings of the National Academy of Sciences of the United States of America.

[13]  R J Stevens,et al.  A cholinergic inhibitory system in the frog optic tectum: its role in visual electrical responses and feeding behavior. , 1973, Brain research.

[14]  R. Sperry,et al.  Tests for neuroplasticity in the anuran retinotectal system. , 1973, Experimental neurology.

[15]  D. Ingle,et al.  Two Visual Systems in the Frog , 1973, Science.

[16]  F. Scalia.  Autoradiographic demonstration of optic nerve fibers in the stratum zonale of the frog's tectum. , 1973, Brain research.

[17]  M. Yoon.  Retention of the original topographic polarity by the 180° rotated tectal reimplant in young adult goldfish , 1973 .

[18]  E. Kicliter.  Flux, wavelength and movement discrimination in frogs: forebrain and midbrain contributions. , 1973, Brain, behavior and evolution.

[19]  D. Colman,et al.  Aspects of the central projection of the optic nerve in the frog as revealed by anterograde migration of horseradish peroxidase. , 1974, Brain research.

[20]  T. Bliss,et al.  The synaptic organization of optic afferents in the amphibian tectum , 1974, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[21]  D. Ingle,et al.  Thalamo-tectal projections in the frog. , 1974, Brain research.

[22]  W. B. Marks,et al.  Optic nerve terminal arborizations in the frog: shape and orientation inferred from electrophysiological measurements. , 1974, Experimental neurology.

[23]  M. Jacobson,et al.  Stability of implanted duplicate tectal positional markers serving as targets for optic axons in adult frogs , 1975, Brain Research.

[24]  M. Jacobson,et al.  Plasticity in the adult frog brain: filling the visual scotoma after excision or translocation of parts of the optic tectum , 1975, Brain Research.

[25]  H. Levitan,et al.  Polyphasic synaptic potentials in the ganglion of the mollusc, Navanax. , 1975, The Journal of physiology.

[26]  M. Keating,et al.  Retinotectal mismatch: a serendipitous experimental result , 1975, Nature.