Diagnosis and management of diabetic autonomic neuropathy

Autonomic neuropathy affects every system in the body including the eye, cardiovascular, respiratory, and gastrointestinal and neurovascular systems. The diagnosis confers an attenuated life expectancy, but much can be done to alleviate symptoms and to address the underlying disorder.

[1]  M. Veglio,et al.  Autonomic neuropathy in non-insulin-dependent diabetic patients: correlation with age, sex, duration and metabolic control of diabetes. , 1990, Diabete & metabolisme.

[2]  P. Watkins,et al.  Postural Hypotension in Diabetic Autonomic Neuropathy: a Review , 1995, Diabetic medicine : a journal of the British Diabetic Association.

[3]  E. Damsgaard,et al.  Cardiovascular autonomic neuropathy in insulin-dependent diabetes mellitus: prevalence and estimated risk of coronary heart disease in the general population. , 2000, Journal of internal medicine.

[4]  R. Freeman,et al.  Diabetic autonomic neuropathy. , 2003, Diabetes care.

[5]  R. Jeyarajah,et al.  Autonomic function tests in non-insulin dependent diabetic patients and apparently healthy volunteers. , 1986, Journal of chronic diseases.

[6]  J. Wishart,et al.  Disordered gastric motor function in diabetes mellitus. Recent insights into prevalence, pathophysiology, clinical relevance, and treatment. , 1991, Scandinavian journal of gastroenterology.

[7]  J. Rajfer,et al.  Sildenafil for treatment of erectile dysfunction in men with diabetes: a randomized controlled trial. Sildenafil Diabetes Study Group. , 1999, JAMA.

[8]  H. Yki-Järvinen,et al.  Mechanisms of altered hemodynamic and metabolic responses to insulin in patients with insulin-dependent diabetes mellitus and autonomic dysfunction. , 1998, The Journal of clinical endocrinology and metabolism.

[9]  D. Ewing,et al.  The natural history of diabetic autonomic neuropathy. , 1980, The Quarterly journal of medicine.

[10]  D. Ewing,et al.  Cardiovascular responses to sustained handgrip in normal subjects and in patients with diabetes mellitus: a test of autonomic function. , 1974, Clinical science and molecular medicine.

[11]  A. Vinik,et al.  Impairment of Peripheral Blood Flow Responses in Diabetes Resembles an Enhanced Aging Effect , 1997, Diabetes Care.

[12]  G. Sundkvist,et al.  Autonomic neuropathy in non‐insulin dependent (type II) diabetes mellitus. Possible influence of obesity , 1990, Journal of internal medicine.

[13]  P. Reinikainen,et al.  Urinary albumin excretion rate is independently related to autonomic neuropathy in type 2 diabetes mellitus , 1999, Journal of internal medicine.

[14]  R. Collins,et al.  Morning peak in the incidence of myocardial infarction: experience in the ISIS-2 trial. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. , 1992, European heart journal.

[15]  F. Kiesewetter,et al.  Neuropathy is a major contributing factor to diabetic erectile dysfunction , 2001, Neurological research.

[16]  L. Niskanen,et al.  Autonomic neuropathy predicts the development of stroke in patients with non-insulin-dependent diabetes mellitus. , 1996, Stroke.

[17]  K. Airaksinen,et al.  Association Between Silent Coronary Artery Disease, Diabetes, and Autonomic Neuropathy: Fact or Fallacy? , 1992, Diabetes Care.

[18]  T. Erbas,et al.  Comparison of Metoclopramide and Erythromycin in the Treatment of Diabetic Gastroparesis , 1993, Diabetes Care.

[19]  P. O'Brien,et al.  The Sensory Symptoms of Diabetic Polyneuropathy Are Improved With α-Lipoic Acid , 2003 .

[20]  R. Bretzel,et al.  Effects of autonomic neuropathy on counterregulation and awareness of hypoglycemia in type 1 diabetic patients. , 1998, Diabetes care.

[21]  A. Karchmer,et al.  Infections in patients with diabetes mellitus. , 1999, The New England journal of medicine.

[22]  A. Vinik,et al.  Abnormal cardiac function in diabetic patients with autonomic neuropathy in the absence of ischemic heart disease. , 1986, The Journal of clinical endocrinology and metabolism.

[23]  I. O'Brien,et al.  The influence of autonomic neuropathy on mortality in insulin-dependent diabetes. , 1991, The Quarterly journal of medicine.

[24]  K. Stansberry,et al.  Primary nociceptive afferents mediate the blood flow dysfunction in non-glabrous (hairy) skin of type 2 diabetes: a new model for the pathogenesis of microvascular dysfunction. , 1999, Diabetes care.

[25]  C. Sninsky,et al.  Diabetes and the gastrointestinal tract. , 1998, Gastroenterology clinics of North America.

[26]  Increased intraoperative cardiovascular morbidity in diabetics with autonomic neuropathy. , 1989, Anesthesiology.

[27]  P. Kopelman,et al.  Silent myocardial ischemia: role of subclinical neuropathy in patients with and without diabetes. , 1993, Journal of the American College of Cardiology.

[28]  A. Vinik,et al.  Recognizing and treating diabetic autonomic neuropathy. , 2001, Cleveland Clinic journal of medicine.

[29]  E. Sharpey-Schafer,et al.  Absent circulatory reflexes in diabetic neuritis. , 1960, Lancet.

[30]  A. T. N. Group,et al.  The relation between QTc interval prolongation and diabetic complications. The EURODIAB IDDM Complication Study Group , 1999, Diabetologia.

[31]  C. Frugoni.  [Myocardial infarction in diabetes]. , 1952, Il Policlinico. Sezione pratica.

[32]  F. Lithner,et al.  Prevalence of gastrointestinal symptoms in young and middle-aged diabetic patients. , 1999, Scandinavian journal of gastroenterology.

[33]  M. Camilleri,et al.  Chronic diarrhea in diabetes mellitus: mechanisms and an approach to diagnosis and treatment. , 1993, Mayo Clinic proceedings.

[34]  H. R. Peterson,et al.  Autonomic influence on cardiovascular performance in diabetic subjects. , 1989, The American journal of medicine.

[35]  F. A. Gries,et al.  The Epidemiology of Diabetic Neuropathy , 1993 .

[36]  E. Faccio,et al.  Autonomic Neuropathy and Painless Myocardial Infarction in Diabetic Patients: Histologic Evidence of Their Relationship , 1977, Diabetes.

[37]  A. Burger,et al.  Circadian patterns of heart rate variability, fibrinolytic activity, and hemostatic factors in type I diabetes mellitus with cardiac autonomic neuropathy. , 1999, The American journal of cardiology.

[38]  F. Gries,et al.  Effects of Treatment With the Antioxidant α-Lipoic Acid on Cardiac Autonomic Neuropathy in NIDDM Patients: A 4-month randomized controlled multicenter trial (DEKAN Study) , 1997, Diabetes Care.

[39]  J M Neilson,et al.  Twenty four hour heart rate variability: effects of posture, sleep, and time of day in healthy controls and comparison with bedside tests of autonomic function in diabetic patients. , 1991, British heart journal.

[40]  K. Demyttenaere,et al.  Diabetes mellitus and female sexuality: a review of 25 years’ research , 1998, Diabetic medicine : a journal of the British Diabetic Association.

[41]  M. Camilleri,et al.  Pilot Study of Pathophysiology of Constipation Among Community Diabetics , 2004, Digestive Diseases and Sciences.

[42]  W. Rathmann,et al.  Mortality in Diabetic Patients with Cardiovascular Autonomic Neuropathy , 1993, Diabetic medicine : a journal of the British Diabetic Association.

[43]  J. Shaw,et al.  A randomised controlled trial of topical glycopyrrolate, the first specific treatment for diabetic gustatory sweating , 1997, Diabetologia.

[44]  E. Corazziari,et al.  Neurologic disorders affecting the anorectum. , 2001, Gastroenterology clinics of North America.

[45]  A. Vinik,et al.  Impaired Peripheral Vasomotion in Diabetes , 1996, Diabetes Care.

[46]  T. Ikeda,et al.  Long-term effect of epalrestat on cardiac autonomic neuropathy in subjects with non-insulin dependent diabetes mellitus. , 1999, Diabetes research and clinical practice.

[47]  H. Abrahamsson.  Gastrointestinal motility disorders in patients with diabetes mellitus , 1995, Journal of internal medicine.

[48]  S. Morimoto,et al.  Circadian Rhythm of Blood Pressure in Normotensive NIDDM Subjects: Its Relationship to Microvascular Complications , 1991, Diabetes Care.

[49]  L. Kuller,et al.  Diabetic autonomic neuropathy and cardiovascular risk. Pittsburgh Epidemiology of Diabetes Complications Study III. , 1990, Archives of internal medicine.

[50]  W. Rathmann,et al.  Prevalence and clinical correlates of cardiovascular autonomic and peripheral diabetic neuropathy in patients attending diabetes centers. The Diacan Multicenter Study Group. , 1993, Diabete & metabolisme.

[51]  B. Lacy,et al.  Tegaserod: a new 5-HT4 agonist. , 2002, Journal of clinical gastroenterology.

[52]  R. Prescott,et al.  The prevalence of diabetic impotence , 1980, Diabetologia.

[53]  O. Pedersen,et al.  Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno type 2 randomised study , 1999, The Lancet.

[54]  G. Sundkvist,et al.  Autonomic Neuropathy Predicts Deterioration in Glomerular Filtration Rate in Patients With IDDM , 1993, Diabetes Care.

[55]  G Steiner,et al.  Detection of silent myocardial ischemia in diabetes mellitus. , 1991, The American journal of cardiology.

[56]  M. Alon,et al.  Pudendal Nerve Conduction to Evaluate Organic Erectile Dysfunction , 2001, American journal of physical medicine & rehabilitation.

[57]  A. Burger,et al.  Effect of glycemic control on heart rate variability in type I diabetic patients with cardiac autonomic neuropathy. , 1999, The American journal of cardiology.

[58]  K. Koch.  Diabetic Gastropathy (Gastric Neuromuscular Dysfunction in Diabetes Mellitus A Review of Symptoms, Pathophysiology, and Treatment) , 1999, Digestive Diseases and Sciences.

[59]  D. Ewing,et al.  Autonomic neuropathy, QT interval lengthening, and unexpected deaths in male diabetic patients , 1991, Diabetologia.