Why do we age?

[1]  T. Kirkwood,et al.  Evolution of the human menopause. , 2001, BioEssays : news and reviews in molecular, cellular and developmental biology.

[2]  George C. Williams,et al.  PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCE , 1957, Science of Aging Knowledge Environment.

[3]  A. Force,et al.  Extended longevity in Drosophila is consistently associated with a decrease in developmental viability. , 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

[4]  T. Kirkwood,et al.  CALORIE RESTRICTION AND AGING: A LIFE‐HISTORY ANALYSIS , 2000, Evolution; international journal of organic evolution.

[5]  G. Lithgow,et al.  Natural selection: Evolution of lifespan in C. elegans , 2000, Nature.

[6]  M. Doebeli,et al.  Experimental evolution of aging, growth, and reproduction in fruitflies. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[7]  G. Barja,et al.  Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[8]  Caleb E. Finch,et al.  Chance, development, and aging , 2000 .

[9]  Z B Zeng,et al.  Genotype-environment interaction for quantitative trait loci affecting life span in Drosophila melanogaster. , 2000, Genetics.

[10]  L. Partridge,et al.  A delayed wave of death from reproduction in Drosophila. , 1999, Science.

[11]  M. Tatar.  Evolution of Senescence: Longevity and the Expression of Heat Shock Proteins , 1999 .

[12]  Pier Paolo Pandolfi,et al.  The p66shc adaptor protein controls oxidative stress response and life span in mammals , 1999, Nature.

[13]  T. Kirkwood.  Time of Our Lives: The Science of Human Aging , 1999 .

[14]  G. Barja,et al.  8-oxo-deoxyguanosine levels in heart and brain mitochondrial and nuclear DNA of two mammals and three birds in relation to their different rates of aging , 1999, Aging.

[15]  S. Ward,et al.  Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[16]  C. K. Lee,et al.  Gene expression profile of aging and its retardation by caloric restriction. , 1999, Science.

[17]  C. Geyer,et al.  Toward reconciling inferences concerning genetic variation in senescence in Drosophila melanogaster. , 1999, Genetics.

[18]  D. Wallace.  Mitochondrial diseases in man and mouse. , 1999, Science.

[19]  T. Kirkwood,et al.  Positive correlation between mammalian life span and cellular resistance to stress. , 1999, Free radical biology & medicine.

[20]  L. Partridge,et al.  Another set of responses and correlated responses to selection on age at reproduction in Drosophila melanogaster , 1999, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[21]  S. Benzer,et al.  Extended life-span and stress resistance in the Drosophila mutant methuselah. , 1998, Science.

[22]  P. Wise.  Female Reproductive Aging , 1998 .

[23]  E. Masoro.  Influence of caloric intake on aging and on the response to stressors. , 1998, Journal of toxicology and environmental health. Part B, Critical reviews.

[24]  R. Ricklefs.  Evolutionary Theories of Aging: Confirmation of a Fundamental Prediction, with Implications for the Genetic Basis and Evolution of Life Span , 1998, The American Naturalist.

[25]  P. Rabinovitch,et al.  Cultured renal epithelial cells from birds and mice: enhanced resistance of avian cells to oxidative stress and DNA damage. , 1998, The journals of gerontology. Series A, Biological sciences and medical sciences.

[26]  A. Yashin,et al.  Biodemographic trajectories of longevity. , 1998, Science.

[27]  D. Martinez,et al.  Mortality Patterns Suggest Lack of Senescence in Hydra , 1998, Experimental Gerontology.

[28]  Craig Packer,et al.  Reproductive cessation in female mammals , 1998, Nature.

[29]  E. Charnov,et al.  Grandmothering, menopause, and the evolution of human life histories. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[30]  L. Keller,et al.  Extraordinary lifespans in ants: a test of evolutionary theories of ageing , 1997, Nature.

[31]  R. Walford,et al.  The response to calorie restriction in mammals shows features also common to hibernation: a cross-adaptation hypothesis. , 1997, The journals of gerontology. Series A, Biological sciences and medical sciences.

[32]  L. Gavrilov,et al.  Parental age at conception and offspring longevity , 1997 .

[33]  T. Kirkwood.  Human senescence , 1996, BioEssays : news and reviews in molecular, cellular and developmental biology.

[34]  L. Partridge,et al.  On measuring the rate of ageing , 1996, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[35]  K. Hughes,et al.  Age-specific inbreeding depression and components of genetic variance in relation to the evolution of senescence. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[36]  D. Promislow,et al.  Age-specific patterns of genetic variance in Drosophila melanogaster. I. Mortality. , 1996, Genetics.

[37]  S. Austad,et al.  Genetic analysis of ageing: role of oxidative damage and environmental stresses , 1996, Nature Genetics.

[38]  R. Short.  Why we age , 1996, Nature.

[39]  J. Vanfleteren,et al.  Rate of aerobic metabolism and superoxide production rate potential in the nematode Caenorhabditis elegans. , 1996, The Journal of experimental zoology.

[40]  W. A. Johnson,et al.  Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[41]  Kim Hill,et al.  Ache Life History: The Ecology and Demography of a Foraging People , 1995 .

[42]  J. S. Peccei.  The origin and evolution of menopause: The altriciality-lifespan hypothesis , 1995 .

[43]  B. Zwaan,et al.  DIRECT SELECTION ON LIFE SPAN IN DROSOPHILA MELANOGASTER , 1995, Evolution; international journal of organic evolution.

[44]  S. Austad.  Menopause: An evolutionary perspective , 1994, Experimental Gerontology.

[45]  Brian Charlesworth,et al.  A genetic analysis of senescence in Drosophila , 1994, Nature.

[46]  R. S. Sohal,et al.  Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species. , 1993, Free radical biology & medicine.

[47]  R. S. Sohal,et al.  Biochemical correlates of longevity in two closely related rodent species. , 1993, Biochemical and biophysical research communications.

[48]  E. W. Hutchinson,et al.  Absence of strong heterosis for life span and other life history traits in Caenorhabditis elegans. , 1993, Genetics.

[49]  S. Austad.  Retarded senescence in an insular population of Virginia opossums (Didelphis virginiana) , 1993 .

[50]  A. Bürkle,et al.  Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[51]  F. Bronson,et al.  Life History AND BIOECONOMY OF THE House Mouse , 1992, Biological reviews of the Cambridge Philosophical Society.

[52]  S. Stearns,et al.  The Evolution of Life Histories , 1992 .

[53]  Thomas E. Johnson,et al.  Evolutionary biology of aging , 1990 .

[54]  Edward L. Schneider,et al.  Handbook of the Biology of Aging , 1990 .

[55]  Caleb E. Finch,et al.  Longevity, senescence, and the genome , 1990 .

[56]  S. Austad.  Life extension by dietary restriction in the bowl and doily spider, Frontinella pyramitela , 1989, Experimental Gerontology.

[57]  S. Austad,et al.  Natural selection, dietary restriction, and extended longevity. , 1989, Growth, development, and aging : GDA.

[58]  Richard Weindruch,et al.  The Retardation of Aging and Disease by Dietary Restriction , 1988 .

[59]  M R Rose,et al.  MULTIPLE GENETIC MECHANISMS FOR THE EVOLUTION OF SENESCENCE IN DROSOPHILA MELANOGASTER , 1988, Evolution; international journal of organic evolution.

[60]  M. Rose,et al.  OF SENESCENCE IN DROSOPHILA MELANOGASTER , 1988 .

[61]  T. Kirkwood,et al.  DNA, mutations and aging. , 1988, Mutation research.

[62]  N. Risch,et al.  Spontaneous mutation and parental age in humans. , 1987, American journal of human genetics.

[63]  A. Bittles,et al.  The biology of human ageing: Frontmatter , 1986 .

[64]  T. Kirkwood,et al.  The biology of human ageing: Ageing as a consequence of natural selection , 1986 .

[65]  E. W. Hutchinson,et al.  Resistance to Environmental Stress in Drosophila melanogaster Selected for Postponed Senescence , 1985, Physiological Zoology.

[66]  Graham Bell,et al.  Evolutionary and Nonevolutionary Theories of Senescence , 1984, The American Naturalist.

[67]  L. Luckinbill,et al.  SELECTION FOR DELAYED SENESCENCE IN DROSOPHILA MELANOGASTER , 1984, Evolution; international journal of organic evolution.

[68]  B. Charlesworth,et al.  Evolution in Age-Structured Populations , 1984 .

[69]  B. Charlesworth,et al.  A test of evolutionary theories of senescence , 1980, Nature.

[70]  R. S. Sohal,et al.  Effects of experimentally altered life spans on the accumulation of fluorescent age pigment in the housefly, Musca domestica , 1978, Experimental Gerontology.

[71]  Gary L. Anderson.  Responses of dauerlarvae of Caenorhabditis elegans (Nematoda: Rhabditidae) to thermal stress and oxygen deprivation , 1978 .

[72]  T. Kirkwood.  Evolution of ageing , 1977, Nature.

[73]  M. Klass,et al.  Non-ageing developmental variant of Caenorhabditis elegans , 1976, Nature.

[74]  W. Hamilton.  The moulding of senescence by natural selection. , 1966, Journal of theoretical biology.

[75]  R. Kohn.  Mutations and Aging. , 1963, Science.

[76]  P. Medawar.  UNSOLVED problem of biology. , 1953, The Medical journal of Australia.