Mutant KRAS drives metabolic reprogramming and autophagic flux in premalignant pancreatic cells
暂无分享,去创建一个
M. Otsuka | K. Koike | T. Kishikawa | Rei Ishibashi | Kazuma Sekiba | M. Ohno | Tatsunori Suzuki | Takahiro Seimiya | Norihiko Takeda | Takuma Iwata | Tatsuyuki Sato | Yuki Sugiura
[1] M. Otsuka,et al. The biological role of metabolic reprogramming in pancreatic cancer , 2020, MedComm.
[2] X. Brannmjk. Capillary , 2020, Definitions.
[3] Davide Risso,et al. Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition , 2020, Nature.
[4] A. Balmain,et al. KRAS4A directly regulates hexokinase 1 , 2019, Nature.
[5] D. Bar-Sagi,et al. Plasma membrane v-ATPase controls oncogenic Ras-induced macropinocytosis , 2019, Nature.
[6] S. C. Chafe,et al. Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia. , 2019, Gastroenterology.
[7] S. Gulati,et al. Analysis of circulating cell-free DNA identifies KRAS copy number gain and mutation as a novel prognostic marker in Pancreatic cancer , 2019, Scientific Reports.
[8] S. Hanash,et al. Syndecan1 is a critical mediator of macropinocytosis in pancreatic cancer , 2019, Nature.
[9] E. Petricoin,et al. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer , 2019, Nature Medicine.
[10] D. Merico,et al. Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases. , 2019, Cancer cell.
[11] J. Yap,et al. Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers , 2019, Nature Medicine.
[12] B. Garcia,et al. Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis. , 2019, Cancer discovery.
[13] A. Levine,et al. The Roles of Initiating Truncal Mutations in Human Cancers: The Order of Mutations and Tumor Cell Type Matters. , 2019, Cancer cell.
[14] A. Jemal,et al. Cancer statistics, 2019 , 2019, CA: a cancer journal for clinicians.
[15] H. Kocher,et al. Pancreatic Cancer , 2019, Methods in Molecular Biology.
[16] R. Bronson,et al. Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis , 2018, Nature Communications.
[17] Kwok-Kin Wong,et al. Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms. , 2018, Cancer discovery.
[18] Charles M. Perou,et al. Asparagine bioavailability governs metastasis in a model of breast cancer , 2018, Nature.
[19] R. White,et al. As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid. , 2018, Cell metabolism.
[20] P. Zarrinkar,et al. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor , 2018, Cell.
[21] Mathias J Friedrich,et al. Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes , 2018, Nature.
[22] A. Aloisi,et al. Assessment of glutathione/glutathione disulphide ratio and S-glutathionylated proteins in human blood, solid tissues, and cultured cells. , 2017, Free radical biology & medicine.
[23] Steven J. M. Jones,et al. Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma. , 2017, Cancer cell.
[24] M. V. Vander Heiden,et al. Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions , 2017, Nature Communications.
[25] Frank McCormick,et al. RAS Proteins and Their Regulators in Human Disease , 2017, Cell.
[26] Jiahuai Han,et al. Repression of MicroRNA Function Mediates Inflammation-associated Colon Tumorigenesis. , 2017, Gastroenterology.
[27] C. Lyssiotis,et al. Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer. , 2017, Cancer cell.
[28] Y. Bhutia,et al. Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer , 2016, British journal of pharmacology.
[29] D. Hayes,et al. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis , 2016, Nature.
[30] Suguru Hasegawa,et al. Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase12 , 2016, Neoplasia.
[31] L. Cantley,et al. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion , 2016, Nature.
[32] Chi V. Dang,et al. From Krebs to clinic: glutamine metabolism to cancer therapy , 2016, Nature Reviews Cancer.
[33] T. Graeber,et al. Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor , 2016, Nature Communications.
[34] L. Postovit,et al. A Digital PCR-Based Method for Efficient and Highly Specific Screening of Genome Edited Cells , 2016, PloS one.
[35] P. Storz,et al. Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions. , 2016, Cell reports.
[36] R. Gibbs,et al. Genomic analyses identify molecular subtypes of pancreatic cancer , 2016, Nature.
[37] Neal Rosen,et al. Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism , 2016, Science.
[38] C. Martins,et al. Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities , 2016, Nature.
[39] T. Horvath,et al. Mitochondrial ROS Signaling in Organismal Homeostasis , 2015, Cell.
[40] Martin L. Miller,et al. Mitochondrial DNA copy number variation across human cancers , 2015, bioRxiv.
[41] J. Kench,et al. Whole genomes redefine the mutational landscape of pancreatic cancer , 2015, Nature.
[42] Lorenzo Galluzzi,et al. Metabolic Control of Autophagy , 2014, Cell.
[43] R. Finn,et al. KRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition , 2014, British Journal of Cancer.
[44] Dihua Yu,et al. Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis , 2014, PloS one.
[45] Gerald C. Chu,et al. Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. , 2014, Cancer discovery.
[46] Amy Y. M. Au,et al. p53 status determines the role of autophagy in pancreatic tumour development , 2013, Nature.
[47] Tomer Shlomi,et al. Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia , 2013, Molecular systems biology.
[48] Christian M. Metallo,et al. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells , 2013, Nature.
[49] John M. Asara,et al. Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway , 2013, Nature.
[50] N. Sunaga,et al. Prognostic significance of L-type amino-acid transporter 1 expression in surgically resected pancreatic cancer , 2012, British Journal of Cancer.
[51] Gerald C. Chu,et al. Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism , 2012, Cell.
[52] T. Fan,et al. The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. , 2012, Cell metabolism.
[53] Masaaki Komatsu,et al. Autophagy: Renovation of Cells and Tissues , 2011, Cell.
[54] D. Bar-Sagi,et al. RAS oncogenes: weaving a tumorigenic web , 2011, Nature Reviews Cancer.
[55] Marc Liesa,et al. Pancreatic cancers require autophagy for tumor growth. , 2011, Genes & development.
[56] M. Tomita,et al. Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles , 2009, Metabolomics.
[57] Jeffrey P. MacKeigan,et al. Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy , 2009, Cell.
[58] G. Parmigiani,et al. Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses , 2008, Science.
[59] E. Ren. Know the enemy , 2006, Nature Biotechnology.
[60] E. Petricoin,et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. , 2003, Cancer cell.
[61] J. Downward. Targeting RAS signalling pathways in cancer therapy , 2003, Nature Reviews Cancer.
[62] R H Hruban,et al. Progression model for pancreatic cancer. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[63] T. Soga,et al. Amino acid analysis by capillary electrophoresis electrospray ionization mass spectrometry. , 2000, Analytical chemistry.
[64] K. Oh,et al. A novel fluorescent derivative of glucose applicable to the assessment of glucose uptake activity of Escherichia coli. , 1996, Biochimica et biophysica acta.
[65] M. Iannuzzi,et al. A cystic fibrosis pancreatic adenocarcinoma cell line. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[66] N. Dubrawsky. Cancer statistics , 1989, CA: a cancer journal for clinicians.
[67] D. Shibata,et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes , 1988, Cell.