Cerebral blood flow sensor with in situ temperature and thermal conductivity compensation

A micromachined blood flow sensor with in situ tissue temperature and thermal conductivity compensation was developed for the continuous and quantitative measurement of intraparenchymal regional cerebral blood flow. The flow sensor operates in a constant-temperature mode and employs a periodic heating and cooling technique. Thermal conductivity compensation is realized by sampling the peak current outputs at the beginning of the heating period and the baseline temperature variation during the heating period is compensated by an integrated temperature sensor. This approach provides highly reliable data with MEMS-based thin film sensors. It achieves sensitivity of 1.467 mV/ml/100gram-min in the linear range from 0 to 160 ml/100gram-min.

[1]  Chong H Ahn,et al.  A novel lab-on-a-tube for multimodality neuromonitoring of patients with traumatic brain injury (TBI). , 2009, Lab on a chip.

[2]  Pei-Ming Wu,et al.  Brain temperature measurement: A study of in vitro accuracy and stability of smart catheter temperature sensors , 2012, Biomedical microdevices.

[3]  Jungyoup Han,et al.  A flexible polymer tube lab-chip integrated with microsensors for smart microcatheter , 2008, Biomedical microdevices.

[4]  J. González-Darder,et al.  Flujometría por difusión termal para la medida del flujo sanguíneo cerebral regional en la cirugía de los aneurismas cerebrales , 2010 .

[5]  Anthony J. Strong,et al.  Multimodal Cerebral Monitoring in Traumatic Brain Injury , 2011 .

[6]  R. Narayan,et al.  Smart catheter flow sensor for continuous regional cerebral blood flow monitoring , 2011, 2011 IEEE SENSORS Proceedings.

[7]  Christine Martin,et al.  Incorporating a parenchymal thermal diffusion cerebral blood flow probe in bedside assessment of cerebral autoregulation and vasoreactivity in patients with severe traumatic brain injury. , 2011, Journal of neurosurgery.

[8]  A. Lam,et al.  Cerebral blood flow and the injured brain: how should we monitor and manipulate it? , 2011, Current opinion in anaesthesiology.

[9]  S. Lee,et al.  Continuous regional cerebral blood flow monitoring in the neurosurgical intensive care unit , 2005, Journal of Clinical Neuroscience.

[10]  M. Zuccarello,et al.  Cerebral Blood Flow Measurement in Neurosurgery , 2011, Translational Stroke Research.

[11]  D. Delpy,et al.  Thermal clearance blood flow sensor—sensitivity, linearity and flow depth discrimination , 1989, Medical and Biological Engineering and Computing.