Asymptomatic renal cell carcinoma with metastasis to the skin and duodenum: a case report and review of the literature

Renal cell carcinoma is known to have blood-borne metastasis. This is usually to the bone, lungs and brain. Other unusual metastatic presentations such as skin and bowel metastasis have also been described. In most cases, the metastasis occurs as a late manifestation in a patient with known primary renal cell carcinoma. A rare synchronous presentation of skin and duodenal metastasis in an otherwise asymptomatic patient is reported here. This patient presented with a skin lesion that, on excision, brought up the diagnosis of metastatic renal cell carcinoma. While the patient was waiting for surgery, she also developed melena that, on gastroscopy, confirmed a duodenal metastasis. This case highlights the importance of early recognition of otherwise unrelated lesions as presentations for an advanced renal malignancy.

[1]  A. Wein,et al.  Campbell-Walsh Urology , 2011 .

[2]  J. Lee,et al.  A Case of Metastatic Renal Cell Carcinoma to Thyroid Gland , 2011, Chonnam medical journal.

[3]  S. Landas,et al.  Recurrent renal cell cancer presenting as gastrointestinal bleed. , 2011, World journal of gastrointestinal oncology.

[4]  P. Rangasamy,et al.  Duodenal Bleeding from Metastatic Renal Cell Carcinoma , 2011, Case Reports in Gastroenterology.

[5]  M. Hoşnuter,et al.  Renal Cell Carcinoma Presenting with Cutaneous Metastasis: A Case Report , 2010, Case reports in medicine.

[6]  P. Karakiewicz,et al.  Treatment of metastatic renal cell carcinoma , 2010, Nature Reviews Urology.

[7]  N. Masood,et al.  Current management of advanced and metastatic renal cell carcinoma. , 2010, Urology journal.

[8]  S. Okazaki,et al.  Metastatic gastric tumor from renal cell carcinoma , 2009, Gastric Cancer.

[9]  H. Brady,et al.  Therapy in Nephrology and Hypertension: A Companion to Brenner & Rector's The Kidney , 2008 .

[10]  M. Garnick Chapter 38 – Primary Neoplasms of the Kidney , 2008 .

[11]  M. J. Pérez-Castejón,et al.  Meta-análisis sobre el rendimiento diagnóstico de la tomografía por emisión de positrones con 18F-FDG en el carcinoma de células renales , 2007 .

[12]  R. Delgado-Bolton,et al.  [Meta-analysis of the diagnostic performance of 18F-FDG PET in renal cell carcinoma]. , 2007, Revista espanola de medicina nuclear.

[13]  A. Vercelli,et al.  Sigmoid Colon Metastasis from Sarcomatoid Renal Cell Carcinoma , 2006, Tumori.

[14]  R. Preetha,et al.  Cutaneous metastasis from silent renal cell carcinoma. , 2004, Journal of postgraduate medicine.

[15]  Thomas J. Mueller,et al.  Cutaneous metastases from genitourinary malignancies. , 2004, Urology.

[16]  P. F. Spooren,et al.  Duodenal metastasis: an uncommon cause of occult small intestinal bleeding. , 2004, The Netherlands journal of medicine.

[17]  G. Sakorafas,et al.  Intestinal metastases from renal cell carcinoma: a rare cause of intestinal obstruction and bleeding. , 2004, The Mount Sinai journal of medicine, New York.

[18]  M. Nishikido,et al.  Renal cell carcinoma metastatic to the skin. , 2000, Anticancer research.

[19]  R. Mendelson,et al.  Duodenal haemorrhage resulting from renal cell carcinoma metastases. , 1995, Australasian radiology.

[20]  C. R. Teixeira [Pancreatic metastasis from renal cell carcinoma]. , 1993, Arquivos de gastroenterologia.

[21]  G. Coppa,et al.  Parotid gland metastasis from renal carcinoma. , 1990, International surgery.

[22]  J. Tschen,et al.  Renal cell carcinoma metastatic to skin. , 1984, Cutis.

[23]  E. B. Helwig,et al.  CUTANEOUS METASTASIS OF RENAL CELL CARCINOMA. , 1963, Archives of pathology.