Developmental mechanisms driving complex tooth shape in reptiles

In mammals, odontogenesis is regulated by transient signaling centers known as enamel knots (EKs), which drive the dental epithelium shaping. However, the developmental mechanisms contributing to formation of complex tooth shape in reptiles are not fully understood. Here, we aim to elucidate whether signaling organizers similar to EKs appear during reptilian odontogenesis and how enamel ridges are formed.

[1]  W. Nelson,et al.  Cell-Cell Junctions Organize Structural and Signaling Networks. , 2018, Cold Spring Harbor perspectives in biology.

[2]  S. Kron,et al.  A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence , 2017, Cell Death Discovery.

[3]  M. Papi,et al.  Biomimetic antimicrobial cloak by graphene-oxide agar hydrogel , 2016, Scientific Reports.

[4]  Takashi Nakamura,et al.  Fine tuning of Rac1 and RhoA alters cuspal shapes by remolding the cellular geometry , 2016, Scientific Reports.

[5]  G. Fraser,et al.  An ancient dental gene set governs development and continuous regeneration of teeth in sharks. , 2016, Developmental biology.

[6]  Jeremy B. A. Green,et al.  Epithelial stratification and placode invagination are separable functions in early morphogenesis of the molar tooth , 2016, Development.

[7]  D. Casane,et al.  Tooth and scale morphogenesis in shark: an alternative process to the mammalian enamel knot system , 2015, BMC Evolutionary Biology.

[8]  Thomas Mangeat,et al.  Apico-basal forces exerted by apoptotic cells drive epithelium folding , 2015, Nature.

[9]  A. Tucker,et al.  The development of complex tooth shape in reptiles , 2014, Front. Physiol..

[10]  A. Abzhanov,et al.  Molecular characterization of dental development in a toothed archosaur, the American alligator Alligator mississippiensis , 2013, Evolution & development.

[11]  A. Tucker,et al.  Odontogenesis in the Veiled Chameleon (Chamaeleo calyptratus). , 2013, Archives of oral biology.

[12]  I. Horáček,et al.  Tooth development in a model reptile: functional and null generation teeth in the gecko Paroedura picta , 2012, Journal of anatomy.

[13]  J. Richman,et al.  Unicuspid and bicuspid tooth crown formation in squamates. , 2011, Journal of experimental zoology. Part B, Molecular and developmental evolution.

[14]  J. Richman,et al.  A network of Wnt, hedgehog and BMP signaling pathways regulates tooth replacement in snakes. , 2010, Developmental biology.

[15]  M. Ferguson,et al.  Development of the dentition in Alligator mississippiensis. Early embryonic development in the lower jaw , 2009 .

[16]  K. Fu,et al.  Initiation and patterning of the snake dentition are dependent on Sonic hedgehog signaling. , 2008, Developmental biology.

[17]  G. Yuan,et al.  Sonic hedgehog signaling is critical for cytodifferentiation and cusp formation in developing mouse molars , 2008, Journal of Molecular Histology.

[18]  I. Morita,et al.  Sonic Hedgehog Signaling is Important in Tooth Root Development , 2006, Journal of dental research.

[19]  Yingnan Song,et al.  Making a tooth: growth factors, transcription factors, and stem cells , 2005, Cell Research.

[20]  Ruei-Jiun Hung,et al.  Assembly of adherens junctions is required for sphingosine 1-phosphate-induced matriptase accumulation and activation at mammary epithelial cell-cell contacts. , 2004, American journal of physiology. Cell physiology.

[21]  Baljit Singh,et al.  Characterization of Matriptase Expression in Normal Human Tissues , 2003, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[22]  S. Wahl,et al.  Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis , 2002, Oncogene.

[23]  A. McMahon,et al.  Sonic hedgehog regulates growth and morphogenesis of the tooth. , 2000, Development.

[24]  P. Sharpe,et al.  Expression of Wnt signalling pathway genes during tooth development , 1999, Mechanisms of Development.

[25]  J. Vonesch,et al.  Aspects of cell proliferation kinetics of the inner dental epithelium during mouse molar and incisor morphogenesis: a reappraisal of the role of the enamel knot area. , 1999, The International journal of developmental biology.

[26]  R. Maas,et al.  FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development. , 1998, Development.

[27]  C. Hui,et al.  The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. , 1998, Development.

[28]  S. Keränen,et al.  The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot. , 1998, Development.

[29]  J. Wozney,et al.  Expression patterns of bone morphogenetic proteins (Bmps) in the developing mouse tooth suggest roles in morphogenesis and cell differentiation , 1997, Developmental dynamics : an official publication of the American Association of Anatomists.

[30]  I. Thesleff,et al.  Signalling networks regulating dental development , 1997, Mechanisms of Development.

[31]  J. Vonesch,et al.  Mouse molar morphogenesis revisited by three-dimensional reconstruction. II. Spatial distribution of mitoses and apoptosis in cap to bell staged first and second upper molar teeth. , 1996, The International journal of developmental biology.

[32]  R. Maas,et al.  Msx1 controls inductive signaling in mammalian tooth morphogenesis. , 1996, Development.

[33]  I. Thesleff,et al.  Evidence for the role of the enamel knot as a control center in mammalian tooth cusp formation: non-dividing cells express growth stimulating Fgf-4 gene. , 1994, The International journal of developmental biology.

[34]  M. Ferguson,et al.  Development of the dentition in Alligator mississippiensis. Later development in the lower jaws of embryos, hatchlings and young juveniles , 1987 .

[35]  P. M. Butler.  THE ONTOGENY OF MOLAR PATTERN , 1956 .

[36]  S. Keränen,et al.  The enamel knot as a signaling center in the developing mouse tooth , 1996, Mechanisms of Development.

[37]  P. Sharpe,et al.  Homeobox genes and orofacial development. , 1995, Connective tissue research.