and PARP cleavage caspases hematopoietic cell death through activation of TRPM2 is an ion channel that modulates

[PDF] [Full Text] [Abstract] , May 1, 2007; 292 (5): C1746-C1758. Am J Physiol Cell Physiol W. Zhang, Q. Tong, K. Conrad, J. Wozney, J. Y. Cheung and B. A. Miller Regulation of TRP channel TRPM2 by the tyrosine phosphatase PTPL1 [PDF] [Full Text] [Abstract] , February 15, 2008; 102 (3): 347-355. Circ. Res. C. M. Hecquet, G. U. Ahmmed, S. M. Vogel and A. B. Malik Hyperpermeability Role of TRPM2 Channel in Mediating H2O2-Induced Ca2+ Entry and Endothelial [PDF] [Full Text] , February 15, 2008; 102 (3): 275-277. Circ. Res. A. Dietrich and T. Gudermann Another TRP to Endothelial Dysfunction: TRPM2 and Endothelial Permeability [PDF] [Full Text] [Abstract] , April 28, 2009; 106 (17): 7239-7244. PNAS J. Du, J. Xie and L. Yue Intracellular calcium activates TRPM2 and its alternative spliced isoforms [PDF] [Full Text] [Abstract] , December 1, 2009; 134 (6): 471-488. J. Gen. Physiol. J. Du, J. Xie and L. Yue Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity

[1]  R. Penner,et al.  Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels. , 2005, Molecular cell.

[2]  Craig Montell,et al.  The TRP Superfamily of Cation Channels , 2005, Science's STKE.

[3]  B. Stoddard,et al.  Accumulation of Free ADP-ribose from Mitochondria Mediates Oxidative Stress-induced Gating of TRPM2 Cation Channels* , 2005, Journal of Biological Chemistry.

[4]  D. H. Kim,et al.  Calcium Binding of ARC Mediates Regulation of Caspase 8 and Cell Death , 2004, Molecular and Cellular Biology.

[5]  S. Skaper,et al.  TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP‐ribose) polymerase , 2004, British journal of pharmacology.

[6]  H. Haas,et al.  Primary human CD34+ hematopoietic stem and progenitor cells express functionally active receptors of neuromediators. , 2004, Blood.

[7]  J. Cheung,et al.  Interaction of TRPC2 and TRPC6 in Erythropoietin Modulation of Calcium Influx* , 2004, Journal of Biological Chemistry.

[8]  J A Peters,et al.  Guide to Receptors and Channels, 1st Edition , 2004, British journal of pharmacology.

[9]  J. Macdonald,et al.  A Key Role for TRPM7 Channels in Anoxic Neuronal Death , 2003, Cell.

[10]  David E. Clapham,et al.  TRP channels as cellular sensors , 2003, Nature.

[11]  Á. Apáti,et al.  Effects of Intracellular Calcium on Cell Survival and the MAPK Pathway in a Human Hormone‐Dependent Leukemia Cell Line (TF‐1) , 2003, Annals of the New York Academy of Sciences.

[12]  Wei He,et al.  Hydrogen peroxide induced down-regulation of CD28 expression of Jurkat cells is associated with a change of site α-specific nuclear factor binding activity and the activation of caspase-3 , 2003, Experimental Gerontology.

[13]  Sten Orrenius,et al.  Calcium: Regulation of cell death: the calcium–apoptosis link , 2003, Nature Reviews Molecular Cell Biology.

[14]  J. Cheung,et al.  A Novel TRPM2 Isoform Inhibits Calcium Influx and Susceptibility to Cell Death* , 2003, The Journal of Biological Chemistry.

[15]  A. Perraud,et al.  TRPM2 Ca2+ permeable cation channels: from gene to biological function. , 2003, Cell calcium.

[16]  Christian R. Halaszovich,et al.  Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD. , 2003, The Biochemical journal.

[17]  J. Eisfeld,et al.  Role and regulation of TRP channels in neutrophil granulocytes. , 2003, Cell calcium.

[18]  A. Perraud,et al.  Critical Intracellular Ca2+ Dependence of Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel Activation* , 2003, The Journal of Biological Chemistry.

[19]  Á. Apáti,et al.  Calcium Induces Cell Survival and Proliferation through the Activation of the MAPK Pathway in a Human Hormone-dependent Leukemia Cell Line, TF-1* , 2003, The Journal of Biological Chemistry.

[20]  T. Denning,et al.  Oxidative stress induces the expression of Fas and Fas ligand and apoptosis in murine intestinal epithelial cells. , 2002, Free radical biology & medicine.

[21]  J. Cheung,et al.  Erythropoietin Modulates Calcium Influx through TRPC2* , 2002, The Journal of Biological Chemistry.

[22]  M. Brizzi,et al.  HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors , 2002, Leukemia.

[23]  J. Eisfeld,et al.  Activation of the Cation Channel Long Transient Receptor Potential Channel 2 (LTRPC2) by Hydrogen Peroxide , 2002, The Journal of Biological Chemistry.

[24]  C. Montell,et al.  The TRP Channels, a Remarkably Functional Family , 2002, Cell.

[25]  H. Matsushime,et al.  Immunocyte Ca2+ Influx System Mediated by LTRPC2 , 2001, Science.

[26]  B. Zhivotovsky,et al.  Cytochrome c Release Occurs via Ca2+-dependent and Ca2+-independent Mechanisms That Are Regulated by Bax* , 2001, The Journal of Biological Chemistry.

[27]  A. Perraud,et al.  ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology , 2001, Nature.

[28]  T. Tuschl,et al.  Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells , 2001, Nature.

[29]  M. Shapero,et al.  Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. , 2001, Cancer research.

[30]  M. Berridge,et al.  The versatility and universality of calcium signalling , 2000, Nature Reviews Molecular Cell Biology.

[31]  S. Zhuang,et al.  p38 Mitogen-activated Protein Kinase Mediates Bid Cleavage, Mitochondrial Dysfunction, and Caspase-3 Activation during Apoptosis Induced by Singlet Oxygen but Not by Hydrogen Peroxide* , 2000, The Journal of Biological Chemistry.

[32]  M. Czaja,et al.  Role of caspases and NF-kappaB signaling in hydrogen peroxide- and superoxide-induced hepatocyte apoptosis. , 2000, American journal of physiology. Gastrointestinal and liver physiology.

[33]  G. Schultz,et al.  From worm to man: three subfamilies of TRP channels , 2000, Trends in Neurosciences.

[34]  J. Pelletier,et al.  Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression. , 2000, Human molecular genetics.

[35]  B. Beattie,et al.  Identification of the Erythropoietin Receptor Domain Required for Calcium Channel Activation* , 1999, The Journal of Biological Chemistry.

[36]  J. Hunter,et al.  Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1). , 1998, Genomics.

[37]  N. Shimizu,et al.  Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain. , 1998, Genomics.

[38]  B. Attali,et al.  Expression of two inward rectifier potassium channels is essential for differentiation of primitive human hematopoietic progenitor cells , 1998, Journal of cellular physiology.

[39]  E. Harhaj,et al.  Bcl-3 expression and nuclear translocation are induced by granulocyte-macrophage colony-stimulating factor and erythropoietin in proliferating human erythroid precursors. , 1998, Blood.

[40]  Yiming Wu,et al.  Calcium transient alternans in blood-perfused ischemic hearts: observations with fluorescent indicator Fura Red. , 1997, American journal of physiology. Heart and circulatory physiology.

[41]  R. Naviaux,et al.  The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses , 1996, Journal of virology.

[42]  S. Baylor,et al.  Use of fura red as an intracellular calcium indicator in frog skeletal muscle fibers. , 1993, Biophysical journal.

[43]  D. Garland,et al.  Phosphorylation of lens fiber cell membrane proteins. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[44]  G. Schultz,et al.  Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia. , 2004, American journal of physiology. Cell physiology.

[45]  J A Peters,et al.  Guide to receptors and channels, 1st edition. , 2004, British journal of pharmacology.

[46]  N. Shimizu,et al.  LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. , 2002, Molecular cell.

[47]  C. Begley,et al.  Anemia But Other bHLH Proteins Are Deficient Expression of SCL Is Normal in Transfusion-Dependent Diamond-Blackfan , 1997 .

[48]  D. Tillotson,et al.  Modulation of calcium channels in human erythroblasts by erythropoietin. , 1997, Blood.