Computer-aided retinal photocoagulation system.

Researchers at the University of Texas at Austin's Biomedical Engineering Laser Laboratory and the U. S. Air Force Academy’s Department of Electrical Engineering are developing a computer-assisted prototype retinal photocoagulation system. The project goal is to rapidly and precisely automatically place laser lesions in the retina for the treatment of disorders such as diabetic retinopathy and retinal tears while dynamically controlling the extent of the lesion. Separate prototype subsystems have been developed to control lesion parameters (diameter or depth) using lesion reflectance feedback and lesion placement using retinal vessels as tracking landmarks. Successful subsystem testing results in vivo on pigmented rabbits using an argon continuous wave laser are presented. A prototype integrated system design to simultaneously control lesion parameters and placement at clinically significant speeds is provided.

[1]  W. Frost Ophthalmic Surgery , 1888, Journal of the American College of Surgeons.

[2]  F. Okuyama,et al.  Eye‐tracking infra‐red optometer , 1990, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[3]  Alessandro Martelli,et al.  Compensation of Random Eye Motion in Television Ophthalmoscopy: Preliminary Results , 1987, IEEE Transactions on Medical Imaging.

[4]  Henry Grady Rylander,et al.  Real-time control of lesion size based on reflectance images , 1992, Photonics West - Lasers and Applications in Science and Engineering.

[5]  Ashley J. Welch,et al.  The preliminary development of a robotic laser system used for ophthalmic surgery , 1987 .

[6]  R C Pruett,et al.  Monochromatic ophthalmoscopy and fundus photography. The normal fundus. , 1977, Archives of ophthalmology.

[7]  Positional control of laser photocoagulator lesions near the fovea. , 1968, The British journal of ophthalmology.

[8]  A J Welch,et al.  Reflectance feedback control of photocoagulation in vivo. , 1993, Archives of ophthalmology.

[9]  Ashley J. Welch,et al.  Automatic control of lesion size in a simulated model of the eye , 1990 .

[10]  Steven F. Barrett,et al.  Digital tracking and control of retinal images , 1994 .

[11]  Y. Yang,et al.  An automated laser system for eye surgery , 1989, IEEE Engineering in Medicine and Biology Magazine.

[12]  L. Arend,et al.  Reading with a macular scotoma. I. Retinal location of scotoma and fixation area. , 1986, Investigative ophthalmology & visual science.

[13]  S. Pizer,et al.  An evaluation of the effectiveness of adaptive histogram equalization for contrast enhancement. , 1988, IEEE transactions on medical imaging.

[14]  H. G. Rylander,et al.  Automated lesion placement in the rabbit eye , 1995, Lasers in surgery and medicine.

[15]  R Machemer,et al.  Retinal oxygenation and laser treatment in patients with diabetic retinopathy. , 1992, American journal of ophthalmology.

[16]  J J Yu,et al.  Eye-tracking system for computer-assisted photocoagulation. , 1991, Ophthalmic surgery.

[17]  G. Timberlake,et al.  Feature-Based Registration of Retinal Images , 1987, IEEE Transactions on Medical Imaging.

[18]  T Bantel,et al.  Global tracking of the ocular fundus pattern imaged by scanning laser ophthalmoscopy. , 1991, International journal of bio-medical computing.

[19]  M L Wolbarsht,et al.  The rationale of photocoagulation therapy for proliferative diabetic retinopathy: a review and a model. , 1980, Ophthalmic surgery.

[20]  H D Crane,et al.  Research study of a fundus tracker for experiments in stabilized vision. NASA CR-1121. , 1968, NASA contractor report. NASA CR. United States. National Aeronautics and Space Administration.

[21]  Harvey F. Silverman,et al.  A Class of Algorithms for Fast Digital Image Registration , 1972, IEEE Transactions on Computers.

[22]  Steven F. Barrett,et al.  Instrumentation for feedback-controlled retinal photocoagualation , 1993, Photonics West - Lasers and Applications in Science and Engineering.

[23]  M Lades,et al.  Measurement of eye rotations in three dimensions and the retinal stimulus projection using scanning laser ophthalmoscopy , 1990, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[24]  H. G. Rylander,et al.  Real-time algorithm for retinal tracking , 1993, IEEE Transactions on Biomedical Engineering.

[25]  D. Snodderly,et al.  Mapping Retinal Features in a Freely Moving Eye with Precise Control of Retinal Stimulus Position , 1978 .

[26]  A J Welch,et al.  Dynamic optical property changes: implications for reflectance feedback control of photocoagulation. , 1992, Journal of photochemistry and photobiology. B, Biology.

[27]  H. D. Crane,et al.  Accurate three-dimensional eyetracker. , 1978, Applied optics.

[28]  H.G. Rylander,et al.  Preliminary results on reflectance feedback control of photocoagulation in vivo , 1994, IEEE Transactions on Biomedical Engineering.