Regional left ventricular myocardial contractility and stress in a finite element model of posterobasal myocardial infarction.

Recently, a noninvasive method for determining regional myocardial contractility, using an animal-specific finite element (FE) model-based optimization, was developed to study a sheep with anteroapical infarction (Sun et al., 2009, "A Computationally Efficient Formal Optimization of Regional Myocardial Contractility in a Sheep With Left Ventricular Aneurysm," ASME J. Biomech. Eng., 131(11), p. 111001). Using the methodology developed in the previous study (Sun et al., 2009, "A Computationally Efficient Formal Optimization of Regional Myocardial Contractility in a Sheep With Left Ventricular Aneurysm," ASME J. Biomech. Eng., 131(11), p. 111001), which incorporates tagged magnetic resonance images, three-dimensional myocardial strains, left ventricular (LV) volumes, and LV cardiac catheterization pressures, the regional myocardial contractility and stress distribution of a sheep with posterobasal infarction were investigated. Active material parameters in the noninfarcted border zone (BZ) myocardium adjacent to the infarct (T(max_B)), in the myocardium remote from the infarct (T(max_R)), and in the infarct (T(max_I)) were estimated by minimizing the errors between FE model-predicted and experimentally measured systolic strains and LV volumes using the previously developed optimization scheme. The optimized T(max_B) was found to be significantly depressed relative to T(max_R), while T(max_I) was found to be zero. The myofiber stress in the BZ was found to be elevated, relative to the remote region. This could cause further damage to the contracting myocytes, leading to heart failure.

[1]  Ming-Ting Wu,et al.  Sequential Changes of Myocardial Microstructure in Patients Postmyocardial Infarction by Diffusion-Tensor Cardiac MR: Correlation With Left Ventricular Structure and Function , 2009, Circulation. Cardiovascular imaging.

[2]  Elena Aikawa,et al.  Diffusion Spectrum MRI Tractography Reveals the Presence of a Complex Network of Residual Myofibers in Infarcted Myocardium , 2009, Circulation. Cardiovascular imaging.

[3]  Elliot R. McVeigh,et al.  Analysis and Visualization of Cardiac Function from MR Images , 1997 .

[4]  D. Bogen,et al.  Large animal model of ischemic mitral regurgitation. , 1994, The Annals of thoracic surgery.

[5]  Samuel T Wall,et al.  Theoretical Impact of the Injection of Material Into the Myocardium: A Finite Element Model Simulation , 2006, Circulation.

[6]  V. Wedeen,et al.  Diffusion Tensor Magnetic Resonance Imaging Mapping the Fiber Architecture Remodeling in Human Myocardium After Infarction: Correlation With Viability and Wall Motion , 2006, Circulation.

[7]  E. McVeigh,et al.  Four-dimensional B-spline based motion analysis of tagged MR images: introduction and in vivo validation. , 2000, Physics in medicine and biology.

[8]  J M Guccione,et al.  Mechanism underlying mechanical dysfunction in the border zone of left ventricular aneurysm: a finite element model study. , 2001, The Annals of thoracic surgery.

[9]  J. Guccione,et al.  MRI-based finite-element analysis of left ventricular aneurysm. , 2005, American journal of physiology. Heart and circulatory physiology.

[10]  Robert C Gorman,et al.  Effect of ventricular size and patch stiffness in surgical anterior ventricular restoration: a finite element model study. , 2005, The Annals of thoracic surgery.

[11]  Yi Liu,et al.  Reconstruction of myocardial tissue motion and strain fields from displacement-encoded MR imaging. , 2009, American journal of physiology. Heart and circulatory physiology.

[12]  A. Tözeren,et al.  Continuum rheology of muscle contraction and its application to cardiac contractility. , 1985, Biophysical journal.

[13]  J W Covell,et al.  Functional implications of myocardial scar structure. , 1997, The American journal of physiology.

[14]  E. McVeigh,et al.  Endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm increases systolic circumferential shortening in sheep. , 2007, The Journal of thoracic and cardiovascular surgery.

[15]  L. Dougherty,et al.  Deformation analysis of 3D tagged cardiac images using an optical flow method , 2010, Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.

[16]  Nielen Stander,et al.  A method for automatically optimizing medical devices for treating heart failure: designing polymeric injection patterns. , 2009, Journal of biomechanical engineering.

[17]  A D McCulloch,et al.  Transmural distribution of three-dimensional strain in the isolated arrested canine left ventricle. , 1991, The American journal of physiology.

[18]  A. McCulloch,et al.  Passive material properties of intact ventricular myocardium determined from a cylindrical model. , 1991, Journal of biomechanical engineering.

[19]  J. Lima,et al.  Pathogenesis of ischemic mitral insufficiency. , 1993, The Journal of thoracic and cardiovascular surgery.

[20]  A D McCulloch,et al.  Mechanics of active contraction in cardiac muscle: Part II--Cylindrical models of the systolic left ventricle. , 1993, Journal of biomechanical engineering.

[21]  David Saloner,et al.  A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysm. , 2009, Journal of biomechanical engineering.

[22]  Litao Yan,et al.  Unsupervised reconstruction of a three‐dimensional left ventricular strain from parallel tagged cardiac images , 2003, Magnetic resonance in medicine.

[23]  E. McVeigh,et al.  The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: a magnetic resonance imaging tagging study. , 2006, The Journal of thoracic and cardiovascular surgery.

[24]  T. Sundt,et al.  Altered Left Ventricular Geometry Changes the Border Zone Temporal Distribution of Stress in an Experimental Model of Left Ventricular Aneurysm: A Finite Element Model Study , 2002, Circulation.

[25]  Edward W Hsu,et al.  Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm. , 2008, The Journal of thoracic and cardiovascular surgery.

[26]  Elliot R. McVeigh,et al.  Analysis of Cardiac Function from MR Images , 1997, IEEE Computer Graphics and Applications.

[27]  J Declerck,et al.  Left ventricular motion reconstruction from planar tagged MR images: a comparison. , 2000, Physics in medicine and biology.

[28]  V. Wedeen,et al.  Diffusion MR tractography of the heart , 2009, Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.

[29]  David Saloner,et al.  Discrimination of myocardial acute and chronic (scar) infarctions on delayed contrast enhanced magnetic resonance imaging with intravascular magnetic resonance contrast media. , 2006, Journal of the American College of Cardiology.

[30]  T. Borg,et al.  Structure and mechanics of healing myocardial infarcts. , 2005, Annual review of biomedical engineering.

[31]  Nielen Stander,et al.  Dor procedure for dyskinetic anteroapical myocardial infarction fails to improve contractility in the border zone. , 2010, The Journal of thoracic and cardiovascular surgery.

[32]  Gabriel Acevedo-Bolton,et al.  First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation. , 2010, The Annals of thoracic surgery.