Age-related total gray matter and white matter changes in normal adult brain. Part I: volumetric MR imaging analysis.

BACKGROUND AND PURPOSE A technique of segmenting total gray matter (GM) and total white matter (WM) in human brain is now available. We investigated the effects of age and sex on total fractional GM (%GM) and total fractional WM (%WM) volumes by using volumetric MR imaging in healthy adults. METHODS Fifty-four healthy volunteers (22 men, 32 women) aged 20-86 years underwent dual-echo fast spin-echo MR imaging. Total GM, total WM, and intracranial space volumes were segmented by using MR image-based computerized semiautomated software. Volumes were normalized as a percentage of intracranial volume (%GM and %WM) to adjust for variations in head size. Age and sex effects were then assessed. RESULTS Both %GM and %WM in the intracranial space were significantly less in older subjects (> or =50 years) than in younger subjects (<50 years) (P <.0001 and P =.02, respectively). Consistently, %GM decreased linearly with age, beginning in the youngest subjects. %WM decreased in a quadratic fashion, with a greater rate beginning only in adult midlife. Although larger GM volumes were observed in men before adjustments for cranium size, no significant differences in %GM or %WM were observed between the sexes. CONCLUSION GM volume loss appears to be a constant, linear function of age throughout adult life, whereas WM volume loss seems to be delayed until middle adult life. Both appear to be independent of sex. Quantitative analysis of %GM and %WM volumes can improve our understanding of brain atrophy due to normal aging; this knowledge may be valuable in distinguishing atrophy of disease patterns from characteristics of the normal aging process.

[1]  J A Corsellis,et al.  VARIATION WITH AGE IN THE VOLUMES OF GREY AND WHITE MATTER IN THE CEREBRAL HEMISPHERES OF MAN: MEASUREMENTS WITH AN IMAGE ANALYSER , 1980, Neuropathology and applied neurobiology.

[2]  R. Terry,et al.  Senile dementia of the Alzheimer type , 1983, Annals of neurology.

[3]  H. Haug,et al.  Are Neurons of the Human Cerebral Cortex Really Lost During Aging? A Morphometric Examination , 1985 .

[4]  R F Spetzler,et al.  Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. II. Postmortem pathological correlations. , 1986, Stroke.

[5]  T. H. Newton,et al.  Foci of MRI signal (pseudo lesions) anterior to the frontal horns: histologic correlations of a normal finding. , 1986, AJR. American journal of roentgenology.

[6]  R. DeTeresa,et al.  Neocortical cell counts in normal human adult aging , 1987, Annals of neurology.

[7]  J. Trojanowski,et al.  Brain MR: pathologic correlation with gross and histopathology. 2. Hyperintense white-matter foci in the elderly. , 1988, AJR. American journal of roentgenology.

[8]  G. Press,et al.  Methods for measuring brain morphologic features on magnetic resonance images. Validation and normal aging. , 1990, Archives of neurology.

[9]  D. Leys,et al.  Periventricular and white matter magnetic resonance imaging hyperintensities do not differ between Alzheimer's disease and normal aging. , 1990, Archives of neurology.

[10]  J. V. van Swieten,et al.  Periventricular lesions in the white matter on magnetic resonance imaging in the elderly. A morphometric correlation with arteriolosclerosis and dilated perivascular spaces. , 1991, Brain : a journal of neurology.

[11]  Scott T. Grafton,et al.  Comparison of postmortem magnetic resonance imaging and neuropathologic findings in the cerebral white matter. , 1991, Archives of neurology.

[12]  F. Fazekas,et al.  The morphologic correlate of incidental punctate white matter hyperintensities on MR images. , 1991, AJNR. American journal of neuroradiology.

[13]  Harry A. Whitaker,et al.  Early effects of normal aging on perseverative and non‐perseverative prefrontal measures , 1992 .

[14]  C. Coffey,et al.  Quantitative cerebral anatomy of the aging human brain , 1992, Neurology.

[15]  W. Meier-Ruge,et al.  Age‐Related White Matter Atrophy in the Human Brain , 1992, Annals of the New York Academy of Sciences.

[16]  F. Fazekas,et al.  Pathologic correlates of incidental MRI white matter signal hyperintensities , 1993, Neurology.

[17]  J. Haxby,et al.  Lack of age-related differences in temporal lobe volume of very healthy adults. , 1994, AJNR. American journal of neuroradiology.

[18]  D. Mathalon,et al.  A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. , 1994, Archives of neurology.

[19]  B. Turetsky,et al.  Sex differences in aging of the human frontal and temporal lobes , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[20]  Dewey Odhner,et al.  3DVIEWNIX: an open, transportable, multidimensional, multimodality, multiparametric imaging software system , 1994, Medical Imaging.

[21]  B. C. Richardson,et al.  Human corpus callosum in aging and alzheimer's disease: a magnetic resonance imaging study , 1994, Neurobiology of Aging.

[22]  Daniel H. Mathalon,et al.  Age-related decline in MRI volumes of temporal lobe gray matter but not hippocampus , 1995, Neurobiology of Aging.

[23]  P. Narayana,et al.  Effect of Radio Frequency Inhomogeneity Correction on the Reproducibility of Intra‐Cranial Volumes Using MR Image Data , 1995, Magnetic resonance in medicine.

[24]  F. Barkhof,et al.  Histopathologic correlates of white matter changes on MRI in Alzheimer's disease and normal aging , 1995, Neurology.

[25]  J. Rapoport,et al.  Quantitative MRI of the temporal lobe, amygdala, and hippocampus in normal human development: Ages 4–18 years , 1995, The Journal of comparative neurology.

[26]  P. Pietrini,et al.  Sex differences in human brain morphometry and metabolism: an in vivo quantitative magnetic resonance imaging and positron emission tomography study on the effect of aging. , 1996, Archives of general psychiatry.

[27]  K. Double,et al.  Topography of brain atrophy during normal aging and alzheimer's disease , 1996, Neurobiology of Aging.

[28]  Jagath C. Rajapakse,et al.  Quantitative Magnetic Resonance Imaging of Human Brain Development: Ages 4–18 , 1996 .

[29]  Supun Samarasekera,et al.  Multiple sclerosis lesion quantification using fuzzy-connectedness principles , 1997, IEEE Transactions on Medical Imaging.

[30]  D. Head,et al.  Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter. , 1997, Cerebral cortex.

[31]  Pradeep Rajagopalan,et al.  Age and sex effects on brain morphology , 1997, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[32]  R. Kikinis,et al.  White matter changes with normal aging , 1998, Neurology.

[33]  J. Kaye,et al.  Brain volume preserved in healthy elderly through the eleventh decade , 1998, Neurology.

[34]  D L Rosene,et al.  Feature article: are neurons lost from the primate cerebral cortex during normal aging? , 1998, Cerebral cortex.

[35]  H. Oguro,et al.  Sex differences in morphology of the brain stem and cerebellum with normal ageing , 1998, Neuroradiology.

[36]  C. Pierpaoli,et al.  Visualizing and characterizing white matter fiber structure and architecture in the human pyramidal tract using diffusion tensor MRI. , 1999, Magnetic resonance imaging.

[37]  M Skalej,et al.  Patterns of age-related shrinkage in cerebellum and brainstem observed in vivo using three-dimensional MRI volumetry. , 1999, Cerebral cortex.

[38]  D. Salat,et al.  Prefrontal gray and white matter volumes in healthy aging and Alzheimer disease. , 1999, Archives of neurology.

[39]  J. Jolles,et al.  Quantitative analysis of magnetization transfer images of the brain: Effect of closed head injury, age and sex on white matter , 1999, Magnetic Resonance in Medicine.

[40]  S. Yamaguchi,et al.  Gender effects on age-related changes in brain structure. , 2000, AJNR. American journal of neuroradiology.

[41]  K. Ishii,et al.  Corticobasal degeneration: evaluation of cortical atrophy by means of hemispheric surface display generated with MR images. , 2000, Radiology.

[42]  J. Townsend,et al.  Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers. , 2000, Radiology.

[43]  Christopher S. Monk,et al.  Mechanisms of Postnatal Neurobiological Development: Implications for Human Development , 2001, Developmental neuropsychology.

[44]  M W Weiner,et al.  Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging , 2001, Magnetic resonance in medicine.

[45]  G. Bartzokis,et al.  Age-related changes in frontal and temporal lobe volumes in men: a magnetic resonance imaging study. , 2001, Archives of general psychiatry.

[46]  Alan C. Evans,et al.  Age and Gender Predict Volume Decline in the Anterior and Posterior Hippocampus in Early Adulthood , 2001, The Journal of Neuroscience.

[47]  L G Nyúl,et al.  Relapsing-remitting Multiple Sclerosis: Fractional Volumetric Analysis of Gray Matter and White Matter , 2000 .

[48]  T. Autti,et al.  MRI of the normal brain from early childhood to middle age , 1994, Neuroradiology.