ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum.
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V. Ord | D. Steinberg | J. Breslow | A. Plump | W. Palinski | J. Witztum | Daniel Steinberg | Joseph L. Witzrum | D. Steinberg
[1] M. Mitchell,et al. Pre-eclampsia and serum antibodies to oxidised low-density lipoprotein , 1994, The Lancet.
[2] J. Breslow. Transgenic mouse models of lipoprotein metabolism and atherosclerosis. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[3] V. Ord,et al. Abundant expression of apoprotein E by macrophages in human and rabbit atherosclerotic lesions. , 1993, Arteriosclerosis and thrombosis : a journal of vascular biology.
[4] J. Witztum. Murine models for study of lipoprotein metabolism and atherosclerosis. , 1993, The Journal of clinical investigation.
[5] R. Hammer,et al. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. , 1993, The Journal of clinical investigation.
[6] D. Steinberg,et al. Oxidatively modified low density lipoprotein is a chemoattractant for human T lymphocytes. , 1993, The Journal of clinical investigation.
[7] J. Qiao,et al. Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II. , 1993, Science.
[8] K. Marotti,et al. Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein , 1993, Nature.
[9] R. Frants,et al. Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia. , 1993, The Journal of biological chemistry.
[10] N. Mackman,et al. Interferon-gamma inhibits macrophage apolipoprotein E production by posttranslational mechanisms. , 1993, The Journal of clinical investigation.
[11] M. Brown,et al. Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance. , 1992, The Journal of biological chemistry.
[12] N. Maeda,et al. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. , 1992, Science.
[13] E. Rubin,et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells , 1992, Cell.
[14] Margaret S. Wu,et al. Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N'-diphenyl-phenylenediamine. , 1992, The Journal of clinical investigation.
[15] J. Salonen,et al. Autoantibody against oxidised LDL and progression of carotid atherosclerosis , 1992, The Lancet.
[16] P. Libby,et al. Increased apolipoprotein E and c-fms gene expression without elevated interleukin 1 or 6 mRNA levels indicates selective activation of macrophage functions in advanced human atheroma. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[17] R. Giscombe,et al. Induction of T-cell activation by oxidized low density lipoprotein. , 1992, Arteriosclerosis and thrombosis : a journal of vascular biology.
[18] H F Hoff,et al. Lesion-derived low density lipoprotein and oxidized low density lipoprotein share a lability for aggregation, leading to enhanced macrophage degradation. , 1991, Arteriosclerosis and thrombosis : a journal of vascular biology.
[19] P. Henriksson,et al. The antioxidant butylated hydroxytoluene protects against atherosclerosis. , 1991, Arteriosclerosis and thrombosis : a journal of vascular biology.
[20] P. Libby,et al. Involvement of the immune system in human atherogenesis: current knowledge and unanswered questions. , 1991, Laboratory investigation; a journal of technical methods and pathology.
[21] D. Steinberg,et al. Role of oxidised low density lipoprotein in atherogenesis. , 1993, British heart journal.
[22] S. Ylä-Herttuala,et al. Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits. , 1990, Arteriosclerosis.
[23] J L Witztum,et al. Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein. , 1990, Arteriosclerosis.
[24] J. Ordovás,et al. Induction of apolipoprotein E gene expression in human and experimental atherosclerotic lesions. , 1990, Biochemical and biophysical research communications.
[25] A. Lusis,et al. Phenotypic characterization of the Ath-1 gene controlling high density lipoprotein levels and susceptibility to atherosclerosis. , 1990, Journal of lipid research.
[26] A. Gown,et al. Direct evidence for a protein recognized by a monoclonal antibody against oxidatively modified LDL in atherosclerotic lesions from a Watanabe heritable hyperlipidemic rabbit. , 1989, The American journal of pathology.
[27] J L Witztum,et al. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. , 1989, The Journal of clinical investigation.
[28] G. Hansson,et al. Detection of activated T lymphocytes in the human atherosclerotic plaque. , 1989, The American journal of pathology.
[29] G. Hansson,et al. Prelesional complement activation in experimental atherosclerosis. Terminal C5b-9 complement deposition coincides with cholesterol accumulation in the aortic intima of hypercholesterolemic rabbits. , 1989, Laboratory investigation; a journal of technical methods and pathology.
[30] B. Paigen,et al. Ath-2, a second gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice. , 1989, Genetics.
[31] J L Witztum,et al. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. , 1989, The New England journal of medicine.
[32] J L Witztum,et al. Low density lipoprotein undergoes oxidative modification in vivo. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[33] M. Haberland,et al. Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits. , 1988, Science.
[34] R. Mahley,et al. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. , 1988, Science.
[35] R. Hammer,et al. Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice. , 1988, Science.
[36] T. Carew,et al. Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[37] A. Ooshima,et al. Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[38] A. Lusis,et al. Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[39] D. Steinberg,et al. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[40] J. Badimón,et al. Quantification and immunolocalization of apolipoprotein E in experimental atherosclerosis. , 1986, Atherosclerosis.
[41] S. Ishibashi,et al. Immunohistochemical localization of apolipoprotein E in atherosclerotic lesions of the aorta and coronary arteries. , 1986, Atherosclerosis.
[42] R. Mahley,et al. Apolipoprotein E Is the Determinant that Mediates the Receptor Uptake of B‐Very Low Density Lipoproteins by Mouse Macrophages , 1986, Arteriosclerosis.
[43] H. Rus,et al. Immunohistochemical localization of the terminal C5b-9 complement complex in human aortic fibrous plaque. , 1985, Atherosclerosis.
[44] G. Gabbiani,et al. Expression of class II transplantation antigen on vascular smooth muscle cells in human atherosclerosis. , 1985, The Journal of clinical investigation.
[45] J. Witztum,et al. Immunogenicity of homologous low density lipoprotein after methylation, ethylation, acetylation, or carbamylation: generation of antibodies specific for derivatized lysine. , 1984, Journal of lipid research.
[46] R. Havel,et al. Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E. , 1981, Proceedings of the National Academy of Sciences of the United States of America.