Cognitive effects of nicotine

Nicotine and other nicotinic agonists have been found to improve performance on attention and memory tasks. Clinical studies using nicotine skin patches have demonstrated the efficacy of nicotine in treating cognitive impairments associated with Alzheimer's disease, schizophrenia, and attention-deficit/hyperactivity disorder. Experimental animal studies have demonstrated the persistence of nicotine-induced working memory improvement with chronic exposure, in addition to the efficacy of a variety of nicotinic agonists. Mechanistic studies have found that alpha7 and alpha4beta2 nicotinic receptors in the hippocampus are critical for nicotinic involvement in cognitive function. Clinical and experimental animal studies provide mutually supporting information for the development of novel nicotinic therapies for cognitive dysfunction.

[1]  E. Levin,et al.  Anticholinergic sensitivity following chronic nicotine administration as measured by radial-arm maze performance in rats. , 1990, Behavioural pharmacology.

[2]  A. Wiser,et al.  Normalization of auditory physiology by cigarette smoking in schizophrenic patients. , 1993, The American journal of psychiatry.

[3]  R Freedman,et al.  Nicotinic receptor function in schizophrenia. , 1996, Schizophrenia bulletin.

[4]  J. Rusted,et al.  Effortful processing is a requirement for nicotine-induced improvements in memory , 1998, Psychopharmacology.

[5]  E. Levin,et al.  Ventral hippocampal ibotenic acid lesions block chronic nicotine-induced spatial working memory improvement in rats. , 1999, Brain research. Cognitive brain research.

[6]  M. Zarrindast,et al.  Effects of nicotine on memory retrieval in mice. , 1996, European journal of pharmacology.

[7]  L. Olson,et al.  Alpha-bungarotoxin binding to hippocampal interneurons: immunocytochemical characterization and effects on growth factor expression , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[8]  D. Moss,et al.  Cholinesterase inhibitors proposed for treating dementia in Alzheimer's disease: selectivity toward human brain acetylcholinesterase compared with butyrylcholinesterase. , 1995, The Journal of pharmacology and experimental therapeutics.

[9]  Cholinergic channel activator, ABT‐418, enhances delayed‐response accuracy in rats , 1997 .

[10]  E. Levin,et al.  Chronic nicotine and withdrawal effects on radial-arm maze performance in rats. , 1990, Behavioral and neural biology.

[11]  T. Taniguchi,et al.  Changes in Nicotinic and Muscarinic Cholinergic Receptors in Alzheimer‐Type Dementia , 1986, Journal of neurochemistry.

[12]  P. Tariot,et al.  A 5-month, randomized, placebo-controlled trial of galantamine in AD , 2000, Neurology.

[13]  D. Warburton,et al.  Evaluation of the information processing and mood effects of a transdermal nicotine patch , 1998, Psychopharmacology.

[14]  D. Hatsukami,et al.  The effects of varying cigarette deprivation duration on cognitive and performance tasks. , 1989, Journal of substance abuse.

[15]  E. Levin,et al.  Transdermal nicotine effects on attention , 1998, Psychopharmacology.

[16]  E. Giacobini,et al.  Nicotinic acetylcholine receptor subtypes in human frontal cortex: Changes in Alzheimer's disease , 1990, Journal of neuroscience research.

[17]  E. Levin,et al.  Nicotinic, muscarinic and dopaminergic actions in the ventral hippocampus and the nucleus accumbens: effects on spatial working memory in rats , 1996, Brain Research.

[18]  R. Friedland,et al.  Nicotine inhibits amyloid formation by the beta-peptide. , 1996, Biochemistry.

[19]  Edward D. Levin,et al.  Bridged nicotine, isonicotine, and norisonicotine effects on working memory performance of rats in the radial‐arm maze , 1999 .

[20]  R. Quirion,et al.  Effect of nicotine and nicotinic receptor agonists on latent inhibition in the rat. , 1996, The Journal of pharmacology and experimental therapeutics.

[21]  P. Sanberg,et al.  Nicotine enhances the learning and memory of aged rats , 1995, Pharmacology Biochemistry and Behavior.

[22]  P. Sargent,et al.  The diversity of neuronal nicotinic acetylcholine receptors. , 1993, Annual review of neuroscience.

[23]  S. Arneric,et al.  Nicotinic receptor agonists facilitate retention of avoidance training: participation of dopaminergic mechanisms. , 1993, Behavioral and neural biology.

[24]  G. Lunt,et al.  Presynaptic modulation of transmitter release by nicotinic receptors. , 1989, Progress in brain research.

[25]  S. Gauthier,et al.  Neurotransmitter and Receptor Deficits in Senile Dementia of the Alzheimer Type , 1986, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[26]  J R Hughes,et al.  Prevalence of smoking among psychiatric outpatients. , 1986, The American journal of psychiatry.

[27]  E. Levin,et al.  Nicotine–Haloperidol Interactions and Cognitive Performance in Schizophrenics , 1996, Neuropsychopharmacology.

[28]  R. Ridley,et al.  Learning impairment following lesion of the basal nucleus of Meynert in the marmoset: Modification by cholinergic drugs , 1986, Brain Research.

[29]  W. Stigelman,et al.  Goodman and Gilman's the Pharmacological Basis of Therapeutics , 1986 .

[30]  E. Perry,et al.  Nicotinic receptor abnormalities in Alzheimer's and Parkinson's diseases. , 1987, Journal of neurology, neurosurgery, and psychiatry.

[31]  S. J. Briggs,et al.  Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection. , 1993, Brain research. Cognitive brain research.

[32]  R. Freedman,et al.  Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia , 1995, Biological Psychiatry.

[33]  E. Levin,et al.  Nicotinic System Involvement in Alzheimer’s and Parkinson’s Diseases , 1997, Drugs & aging.

[34]  S. J. Briggs,et al.  Chronic nicotine‐induced improvement of spatial working memory and D2 dopamine effects in rats , 1996 .

[35]  E. Peskind,et al.  Galantamine in AD , 2000, Neurology.

[36]  K. Davis,et al.  Experimental Approaches to Cognitive Disturbance in Alzheimer's Disease , 1998, Harvard review of psychiatry.

[37]  Edward D Levin,et al.  Effects of nicotinic dimethylaminoethyl esters on working memory performance of rats in the radial-arm maze , 1995, Pharmacology Biochemistry and Behavior.

[38]  S. Wonnacott,et al.  Presynaptic nicotinic ACh receptors , 1997, Trends in Neurosciences.

[39]  E. Levin,et al.  Nicotinic antagonist administration into the ventral hippocampus and spatial working memory in rats , 1997, Neuroscience.

[40]  Bengt Winblad,et al.  Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains , 1988, Neuroscience Letters.

[41]  R. D. Schwartz.  Autoradiographic distribution of high affinity muscarinic and nicotinic cholinergic receptors labeled with [3H]acetylcholine in rat brain. , 1986, Life sciences.

[42]  J. Gray,et al.  Nicotine induces long-lasting potentiation in the dentate gyrus of nicotine-primed rats , 1997, Neuroscience Research.

[43]  E. Levin,et al.  AR-R 17779, an α7 nicotinic agonist, improves learning and memory in rats , 1999 .

[44]  S. Arneric,et al.  Diversity of neuronal nicotinic acetylcholine receptors: lessons from behavior and implications for CNS therapeutics. , 1995, Life sciences.

[45]  P. Sanberg,et al.  Nicotine enhances morris water maze performance of young and aged rats , 1995, Neurobiology of Aging.

[46]  E. Levin,et al.  Nicotinic acetylcholine involvement in cognitive function in animals , 1998, Psychopharmacology.

[47]  A. Nordberg.  Clinical studies in Alzheimer patients with positron emission tomography , 1993, Behavioural Brain Research.

[48]  S. Arneric,et al.  Effects of ABT-418, a novel cholinergic channel ligand, on place learning in septal-lesioned rats. , 1994, European journal of pharmacology.

[49]  M. Aceto,et al.  Nicotine binding sites and their localization in the central nervous system , 1981, Neuroscience & Biobehavioral Reviews.

[50]  P. Sanberg,et al.  Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21 , 1995, Brain Research.

[51]  D. G. Williams,et al.  Effects of cigarette smoking on immediate memory and performance in different kinds of smoker. , 1980, British journal of psychology.

[52]  J. Gray,et al.  6-OHDA Lesions of the Nucleus Accumbens Accentuate Memory Deficits in Animals with Lesions to the Forebrain Cholinergic Projection System: Effects of Nicotine Administration on Learning and Memory in the Water Maze , 1996, Neurobiology of Learning and Memory.

[53]  E. Levin,et al.  Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer’s disease , 1999, Psychopharmacology.

[54]  The effects of nicotine in dermal plaster on cognitive functions in patients with Alzheimer's disease. , 1996, Dementia.

[55]  E D Levin,et al.  Nicotine and attention in adult attention deficit hyperactivity disorder (ADHD). , 1996, Psychopharmacology bulletin.

[56]  E D Levin,et al.  Development of nicotinic drug therapy for cognitive disorders. , 2000, European journal of pharmacology.

[57]  Jack E. Henningfield,et al.  Nicotine and Smoking: A Review of Effects on Human Performance , 1994 .

[58]  R. Gray,et al.  Hippocampal synaptic transmission enhanced by low concentrations of nicotine , 1996, Nature.

[59]  D L Price,et al.  Alzheimer's disease: a disorder of cortical cholinergic innervation. , 1983, Science.

[60]  S. J. Briggs,et al.  Chronic Nicotinic Agonist and Antagonist Effects on T-maze Alternation , 1997, Physiology & Behavior.

[61]  A. Wevers.  Nicotinic receptors in Alzheimer's disease , 2000, European Neuropsychopharmacology.

[62]  E D Levin,et al.  Acute nicotine interactions with nicotinic and muscarinic antagonists: working and reference memory effects in the 16-arm radial maze. , 1997, Behavioural pharmacology.

[63]  C. Pert,et al.  Autoradiographic distribution of nicotine receptors in rat brain , 1984, Brain Research.

[64]  J. Rinne,et al.  A postmortem study of brain nicotinic receptors in Parkinson's and Alzheimer's disease , 1991, Brain Research.

[65]  J. Gray,et al.  Are the cognitive-enhancing effects of nicotine in the rat with lesions to the forebrain cholinergic projection system mediated by an interaction with the noradrenergic system? , 1994, Pharmacology Biochemistry and Behavior.

[66]  M. Monuteaux,et al.  A pilot controlled clinical trial of ABT-418, a cholinergic agonist, in the treatment of adults with attention deficit hyperactivity disorder. , 1999, The American journal of psychiatry.

[67]  L. Jarrard.  What does the hippocampus really do? , 1995, Behavioural Brain Research.

[68]  S. Arneric,et al.  Effects of lobeline, a nicotinic receptor agonist, on learning and memory , 1993, Pharmacology Biochemistry and Behavior.

[69]  M. Ohno,et al.  Blockade of hippocampal nicotinic receptors impairs working memory but not reference memory in rats , 1993, Pharmacology Biochemistry and Behavior.

[70]  S. J. Briggs,et al.  Chronic nicotinic stimulation and blockade effects on working memory. , 1993, Behavioural pharmacology.

[71]  P. Decina,et al.  Cigarette smoking and neuroleptic-induced parkinsonism , 1990, Biological Psychiatry.

[72]  E. Levin,et al.  Nicotine Effects on Memory Performance , 1995 .

[73]  R. Kumar,et al.  Nicotine and smoking. , 1981, Current developments in psychopharmacology.

[74]  B. Sahakian,et al.  The Effects of Nicotine on Attention, Information Processing, and Short-Term Memory in Patients with Dementia of the Alzheimer Type , 1989, British Journal of Psychiatry.

[75]  F. Fadda,et al.  Serotonin and acetylcholine release response in the rat hippocampus during a spatial memory task , 1999, Neuroscience.

[76]  E. Giacobini,et al.  The Cholinergic Receptor System in the Frontal Lobe of Alzheimer Patients , 1988 .

[77]  K. Sekizawa,et al.  Nicotine improves cognitive disturbance in rodents fed with a choline-deficient diet , 1991, Pharmacology Biochemistry and Behavior.

[78]  S B Dunnett,et al.  Proactive interference effects on short-term memory in rats: I. Basic parameters and drug effects. , 1990, Behavioral neuroscience.

[79]  L. Wilkins.  Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension , 2000, Neurology.

[80]  J. McCarten,et al.  Nicotine patches in Alzheimer's disease: Pilot study on learning, memory, and safety , 1995, Pharmacology Biochemistry and Behavior.