Nanoscale Bioactive Glasses in Medical Applications

This review focuses on recent advances in the development and use of nanoscale silicate bioactive glasses for medical applications. In the context of materials for bone substitution, dental applications, and bone tissue engineering, nanoscale bioactive glasses have been gaining attention due to their expected superior osteoconductivity when compared with conventional (micrometer-sized) bioactive glass materials. A detailed overview of recent developments in the field of nanoscale bioactive glasses will be given, including a summary of common fabrication methods and diverse application areas which include tissue engineering scaffolds and coatings, drug delivery devices, and dentistry. The nanofeatures characteristic of this type of bioactive glasses and the possibilities to expand their use in biomedical applications (nanomedicine) are highlighted.

[1]  Hyoun‐Ee Kim,et al.  Sol-gel derived nanoscale bioactive glass (NBG) particles reinforced poly(ε-caprolactone) composites for bone tissue engineering. , 2013, Materials science & engineering. C, Materials for biological applications.

[2]  J. K. Leach,et al.  Proangiogenic Potential of a Collagen/Bioactive Glass Substrate , 2008, Pharmaceutical Research.

[3]  G. Sui,et al.  Osteocompatibility characterization of polyacrylonitrile carbon nanofibers containing bioactive glass nanoparticles , 2013 .

[4]  Afsaneh Amiri,et al.  Transplantation of nano-bioglass/gelatin scaffold in a non-autogenous setting for bone regeneration in a rabbit ulna , 2012, Journal of Materials Science: Materials in Medicine.

[5]  G. Marshall,et al.  Enhanced osteocalcin expression by osteoblast-like cells (MC3T3-E1) exposed to bioactive coating glass (SiO2-CaO-P2O5-MgO-K2O-Na2O system) ions. , 2009, Acta biomaterialia.

[6]  A. Doostmohammadi,et al.  Bioactive glass nanopowder and bioglass coating for biocompatibility improvement of metallic implant , 2009 .

[7]  João F Mano,et al.  Nanostructured multilayer coatings combining chitosan with bioactive glass nanoparticles. , 2009, Journal of nanoscience and nanotechnology.

[8]  Yan Dong,et al.  Nano-sized 58S bioactive glass enhances proliferation and osteogenic genes expression of osteoblast-like cells. , 2012, The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association.

[9]  D. Ficai,et al.  Synthesis and characterization of collagen/hydroxyapatite: magnetite composite material for bone cancer treatment , 2010, Journal of materials science. Materials in medicine.

[10]  T. Webster,et al.  Mimicking the nanofeatures of bone increases bone-forming cell adhesion and proliferation , 2005 .

[11]  Hae-Won Kim,et al.  Robocasting chitosan/nanobioactive glass dual-pore structured scaffolds for bone engineering , 2012 .

[12]  M. Fathi,et al.  Antibacterial effects of sol-gel-derived bioactive glass nanoparticle on aerobic bacteria. , 2010, Journal of biomedical materials research. Part A.

[13]  Aldo R Boccaccini,et al.  The pro-angiogenic properties of multi-functional bioactive glass composite scaffolds. , 2011, Biomaterials.

[14]  Sang-Hyun Kim,et al.  Synthesis of high surface area mesoporous bioactive glass nanospheres , 2010 .

[15]  Aldo R Boccaccini,et al.  Accelerated mineralization of dense collagen-nano bioactive glass hybrid gels increases scaffold stiffness and regulates osteoblastic function. , 2011, Biomaterials.

[16]  Julian R. Jones,et al.  Laser Spinning of Bioactive Glass Nanofibers , 2009 .

[17]  W. Stark,et al.  Radio-opaque nanosized bioactive glass for potential root canal application: evaluation of radiopacity, bioactivity and alkaline capacity. , 2010, International endodontic journal.

[18]  M. Leite,et al.  Characterization and induction of cementoblast cell proliferation by bioactive glass nanoparticles , 2012, Journal of tissue engineering and regenerative medicine.

[19]  C. Balagna,et al.  3D glass-ceramic scaffolds with antibacterial properties for bone grafting , 2008 .

[20]  Fan Yang,et al.  The future of biologic coatings for orthopaedic implants. , 2013, Biomaterials.

[21]  Tao Jiang,et al.  Low temperature electrophoretic deposition of porous chitosan/silk fibroin composite coating for titanium biofunctionalization , 2011 .

[22]  Francesco Baino,et al.  Three-dimensional glass-derived scaffolds for bone tissue engineering: current trends and forecasts for the future. , 2011, Journal of biomedical materials research. Part A.

[23]  D. Brauer,et al.  Surface properties and ion release from fluoride-containing bioactive glasses promote osteoblast differentiation and mineralization in vitro. , 2013, Acta biomaterialia.

[24]  M. Vallet‐Regí,et al.  Mesoporous bioactive scaffolds prepared with cerium-, gallium- and zinc-containing glasses. , 2013, Acta biomaterialia.

[25]  J. Mano,et al.  Micropatterning of bioactive glass nanoparticles on chitosan membranes for spatial controlled biomineralization. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[26]  Juan Pou,et al.  Rapid production of ultralong amorphous ceramic nanofibers by laser spinning , 2007 .

[27]  E. Söderling,et al.  Antibacterial effects of a bioactive glass paste on oral microorganisms. , 1998, Acta odontologica Scandinavica.

[28]  W J Stark,et al.  Antimicrobial Effect of Nanometric Bioactive Glass 45S5 , 2007, Journal of dental research.

[29]  Cato T. Laurencin,et al.  Nanotechnology and orthopedics: a personal perspective. , 2009, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[30]  M. Fathi,et al.  Novel hydroxyapatite–forsterite–bioglass nanocomposite coatings with improved mechanical properties , 2011 .

[31]  J. Mano,et al.  Development of bioactive and biodegradable chitosan-based injectable systems containing bioactive glass nanoparticles. , 2009, Acta biomaterialia.

[32]  Stefan Kaskel,et al.  Proliferation, differentiation and gene expression of osteoblasts in boron-containing associated with dexamethasone deliver from mesoporous bioactive glass scaffolds. , 2011, Biomaterials.

[33]  João F. Mano,et al.  Polymer/bioactive glass nanocomposites for biomedical applications: A review , 2010 .

[34]  A. Moorthi Synthesis, characterization and biological action of nano bioglass ceramic particles for bone formation , 2012 .

[35]  Julian R Jones,et al.  Review of bioactive glass: from Hench to hybrids. , 2013, Acta biomaterialia.

[36]  A. Doostmohammadi,et al.  Genotoxicity effects of nano bioactive glass and Novabone bioglass on gingival fibroblasts using single cell gel electrophoresis (comet assay): An in vitro study , 2012, Dental research journal.

[37]  Ye Jia,et al.  Electrospinning preparation and drug delivery properties of Eu3+/Tb3+ doped mesoporous bioactive glass nanofibers. , 2012, Journal of colloid and interface science.

[38]  Zhijun Ma,et al.  Core–shell glass fibers with high bioactivity and good flexibility , 2012 .

[39]  Larry L. Hench,et al.  Broad-Spectrum Bactericidal Activity of Ag2O-Doped Bioactive Glass , 2002, Antimicrobial Agents and Chemotherapy.

[40]  J. Mano,et al.  A nanotectonics approach to produce hierarchically organized bioactive glass nanoparticles-based macrospheres. , 2012, Nanoscale.

[41]  Peter X Ma,et al.  Nanostructured Biomaterials for Regeneration , 2008, Advanced functional materials.

[42]  Qizhi Chen,et al.  Optimization of Bioglass® Scaffold Fabrication Process , 2011 .

[43]  H. Kim,et al.  Bone regeneration by bioactive hybrid membrane containing FGF2 within rat calvarium. , 2010, Journal of biomedical materials research. Part A.

[44]  A. Boccaccini,et al.  Bioactive glasses as carriers for bioactive molecules and therapeutic drugs: a review , 2012, Journal of Materials Science: Materials in Medicine.

[45]  F. Tavangarian,et al.  Nanostructured bioactive glass coating on porous hydroxyapatite scaffold for strength enhancement , 2008 .

[46]  Aldo R Boccaccini,et al.  45S5 Bioglass-derived glass-ceramic scaffolds for bone tissue engineering. , 2006, Biomaterials.

[47]  N. West,et al.  Synthesis of nanobioglass and formation of apatite rods to occlude exposed dentine tubules and eliminate hypersensitivity. , 2010, Acta biomaterialia.

[48]  R. Reis,et al.  Preparation and in vitro characterization of scaffolds of poly(L-lactic acid) containing bioactive glass ceramic nanoparticles. , 2008, Acta biomaterialia.

[49]  W. Stark,et al.  Do bioactive glasses convey a disinfecting mechanism beyond a mere increase in pH? , 2008, International endodontic journal.

[50]  T. Albrektsson,et al.  Osteoinduction, osteoconduction and osseointegration , 2001, European Spine Journal.

[51]  Aldo R Boccaccini,et al.  Assessment of polyglycolic acid mesh and bioactive glass for soft-tissue engineering scaffolds. , 2004, Biomaterials.

[52]  G. Lim,et al.  Processing of fine hydroxyapatite powders via an inverse microemulsion route , 1996 .

[53]  Jayanth Panyam,et al.  Biodegradable nanoparticles for drug and gene delivery to cells and tissue. , 2003, Advanced drug delivery reviews.

[54]  H. Hajiali,et al.  Preparation of a novel biodegradable nanocomposite scaffold based on poly (3-hydroxybutyrate)/bioglass nanoparticles for bone tissue engineering , 2010, Journal of materials science. Materials in medicine.

[55]  H. Kim,et al.  Odontogenic responses of human dental pulp cells to collagen/nanobioactive glass nanocomposites. , 2012, Dental materials : official publication of the Academy of Dental Materials.

[56]  C. Martínez,et al.  Preparation and bioactive properties of novel bone-repair bionanocomposites based on hydroxyapatite and bioactive glass nanoparticles. , 2012, Journal of biomedical materials research. Part B, Applied biomaterials.

[57]  Maria de Fátima Leite,et al.  Development of biodegradable polyurethane and bioactive glass nanoparticles scaffolds for bone tissue engineering applications. , 2012, Journal of biomedical materials research. Part B, Applied biomaterials.

[58]  A. Doostmohammadi,et al.  Bioactive Glass Nanopowder for the Treatment of Oral Bone Defects , 2007 .

[59]  M. Vallet‐Regí,et al.  Magnetic mesoporous silica spheres for hyperthermia therapy. , 2010, Acta biomaterialia.

[60]  M. Vallet‐Regí,et al.  Bioactive Glasses: From Macro to Nano , 2013 .

[61]  M. Mozafari,et al.  Development of macroporous nanocomposite scaffolds of gelatin/bioactive glass prepared through layer solvent casting combined with lamination technique for bone tissue engineering , 2010 .

[62]  J. Mano,et al.  Preparation and characterization of bioactive glass nanoparticles prepared by sol–gel for biomedical applications , 2011, Nanotechnology.

[63]  Delbert E Day,et al.  Bioactive glass in tissue engineering. , 2011, Acta biomaterialia.

[64]  Robert N Grass,et al.  Remineralization of human dentin using ultrafine bioactive glass particles. , 2007, Acta biomaterialia.

[65]  Aldo R Boccaccini,et al.  A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics. , 2011, Biomaterials.

[66]  A. Boccaccini,et al.  Chitosan membranes containing micro or nano-size bioactive glass particles: evolution of biomineralization followed by in situ dynamic mechanical analysis. , 2013, Journal of the mechanical behavior of biomedical materials.

[67]  L. N. Furini,et al.  Synthesis and thermal properties of nanoparticles of bioactive glasses containing silver , 2009 .

[68]  Sheryl E. Philip,et al.  Poly(3-hydroxybutyrate) multifunctional composite scaffolds for tissue engineering applications. , 2010, Biomaterials.

[69]  W. Stark,et al.  Effect of nanoparticulate bioactive glass particles on bioactivity and cytocompatibility of poly(3-hydroxybutyrate) composites , 2010, Journal of The Royal Society Interface.

[70]  J. Mano,et al.  Chitosan/bioactive glass nanoparticles composites for biomedical applications , 2012, Biomedical materials.

[71]  Ashraf F. Ali,et al.  Synthesis, characterization and microbiological response of silver doped bioactive glass nanoparticles , 2012 .

[72]  D. Boyd,et al.  Time-dependent evaluation of mechanical properties and in vitro cytocompatibility of experimental composite-based nerve guidance conduits. , 2011, Journal of the mechanical behavior of biomedical materials.

[73]  R. Hussain,et al.  In vitro study of nano-sized zinc doped bioactive glass , 2013 .

[74]  C. Schmid,et al.  Characterization of zinc-releasing three-dimensional bioactive glass scaffolds and their effect on human adipose stem cell proliferation and osteogenic differentiation. , 2009, Acta biomaterialia.

[75]  Sheryl E. Philip,et al.  Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass composites. , 2008, Biomaterials.

[76]  A. Boccaccini,et al.  Magnesium‐Containing Bioactive Glasses for Biomedical Applications , 2012 .

[77]  W. Stark,et al.  Bioactive glass (type 45S5) nanoparticles: in vitro reactivity on nanoscale and biocompatibility , 2012, Journal of Nanoparticle Research.

[78]  Heejoo Kim,et al.  Production and Potential of Bioactive Glass Nanofibers as a Next‐Generation Biomaterial , 2006 .

[79]  Larry L. Hench,et al.  Bioglass ®45S5 Stimulates Osteoblast Turnover and Enhances Bone Formation In Vitro: Implications and Applications for Bone Tissue Engineering , 2000, Calcified Tissue International.

[80]  H. Vali,et al.  Influence of calcinated and non calcinated nanobioglass particles on hardness and bioactivity of sol–gel-derived TiO2–SiO2 nano composite coatings on stainless steel substrates , 2011, Journal of materials science. Materials in medicine.

[81]  J. Jansen,et al.  Chitosan/bioactive glass nanoparticle composite membranes for periodontal regeneration. , 2012, Acta biomaterialia.

[82]  B. Lei,et al.  Versatile fabrication of nanoscale sol–gel bioactive glass particles for efficient bone tissue regeneration , 2012 .

[83]  A. U. Daniels,et al.  Bioactive glass nanoparticles with negative zeta potential , 2011 .

[84]  W. Stark,et al.  Glass and bioglass nanopowders by flame synthesis. , 2006, Chemical communications.

[85]  T. Webster,et al.  Enhanced functions of osteoblasts on nanophase ceramics. , 2000, Biomaterials.

[86]  S. Spriano,et al.  Synthesis and characterization of coprecipitation-derived ferrimagnetic glass-ceramic , 2006 .

[87]  Thommey P. Thomas,et al.  Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer. , 2005, Cancer research.

[88]  F. Paqué,et al.  Fine-tuning of Bioactive Glass for Root Canal Disinfection , 2009, Journal of dental research.

[89]  K. Chennazhi,et al.  Biocompatible alginate/nano bioactive glass ceramic composite scaffolds for periodontal tissue regeneration. , 2012, Carbohydrate polymers.

[90]  A. Boccaccini,et al.  Evaluation of angiogenesis of bioactive glass in the arteriovenous loop model. , 2013, Tissue engineering. Part C, Methods.

[91]  P. Manivasakan,et al.  Synthesis, characterization and biological response of magnesium-substituted nanobioactive glass particles for biomedical applications , 2013 .

[92]  M. Jahanshahi,et al.  Synthesis of nano-bioactive glass–ceramic powders and its in vitro bioactivity study in bovine serum albumin protein , 2011 .

[93]  Xin-xing Feng,et al.  Fabrication and characterization of silk fibroin/bioactive glass composite films , 2012 .

[94]  S. Karbasi,et al.  Bonding Strength, Hardness and Bioactivity of Nano Bioglass-Titania Nano Composite Coating Deposited on NiTi Nails , 2011 .

[95]  J. Nedelec,et al.  New strontium-based bioactive glasses: physicochemical reactivity and delivering capability of biologically active dissolution products , 2009 .

[96]  G. Stucky,et al.  Spherical bioactive glass with enhanced rates of hydroxyapatite deposition and hemostatic activity. , 2006, Small.

[97]  C. Sharma,et al.  Magnetic and degradable polymer/bioactive glass composite nanoparticles for biomedical applications. , 2013, Colloids and surfaces. B, Biointerfaces.

[98]  W. Lu,et al.  Bioactive borosilicate glass scaffolds: in vitro degradation and bioactivity behaviors , 2009, Journal of materials science. Materials in medicine.

[99]  Shanshan Huang,et al.  Self-activated luminescent and mesoporous strontium hydroxyapatite nanorods for drug delivery. , 2010, Biomaterials.

[100]  H. Kim,et al.  Providing osteogenesis conditions to mesenchymal stem cells using bioactive nanocomposite bone scaffolds , 2012 .

[101]  R. Appleyard,et al.  Effects of bioactive glass nanoparticles on the mechanical and biological behavior of composite coated scaffolds. , 2011, Acta biomaterialia.

[102]  Aldo R Boccaccini,et al.  Effect of bioactive glasses on angiogenesis: a review of in vitro and in vivo evidences. , 2010, Tissue engineering. Part B, Reviews.

[103]  T. Young,et al.  The development of magnetic degradable DP-Bioglass for hyperthermia cancer therapy. , 2007, Journal of biomedical materials research. Part A.

[104]  Aldo R. Boccaccini,et al.  Preparation and characterisation of poly(lactide-co-glycolide) (PLGA) and PLGA/Bioglass® composite tubular foam scaffolds for tissue engineering applications , 2005 .

[105]  Bushra Parveen,et al.  Preparation and in vitro bioactivity of zinc containing sol-gel-derived bioglass materials. , 2004, Journal of biomedical materials research. Part A.