Two Examples of Severe Fetal Disease Due to ABO Incompatibility

From the Department of Pediatrics, Hospital of the University of Pennsylvania and the University of Pennsylvania School of Medicine, Philadelphia, Pa. 19104. IN 1944, Halbrecht demonstrated that jaundice on the first day of life, due to hemolytic disease of the newborn was frequently associated with ABO incompatibility between fetus and mother. Earlier workers believed that all types of ABO heterospecific pregnancy could result in ABO HDN, but later large-scale investigations have made it clear that this disease is virtually limited to group 0 mothers with hetcrospecific infants.2> 3 The antibodies which are associated with ABO hemolytic disease are of the IgG (gamma-G) or 7-S type. These are incomplete antibodies,4-~ and

[1]  G. Munk-Andersen.  Excess of group O-mothers in ABO-haemolytic disease. , 2009, Acta pathologica et microbiologica Scandinavica.

[2]  J. Soothill,et al.  Immunological responses to early and late intrauterine virus infections. , 1969, The Journal of pediatrics.

[3]  M. Werthmann,et al.  Immunoglobulin M determinations in neonates and infants as an adjunct to the diagnosis of infection. , 1969, The Journal of pediatrics.

[4]  C. Bowley,et al.  A Detailed Serological Study on the Prediction and Diagnosis of ABO Haemolytic Disease of the Newborn (ABO HD) , 1969, Vox sanguinis.

[5]  W. Zuelzer,et al.  Interrelationship of Erythrocyte Blood Group Substances A, B, and H Studied with Immunofluorescence 1 , 1969, Vox sanguinis.

[6]  H. D. Palmer,et al.  Screening for Hemolytic Disease of the Newborn by Cord Blood Coombs Testing— , 1968, Clinical pediatrics.

[7]  P. Mollison,et al.  Progress in Hematology , 1957 .

[8]  Miller Df,et al.  FATAL ERYTHROBLASTOSIS FETALIS SECONDARY TO ABO INCOMPATIBILITY. REPORT OF A CASE. , 1963 .

[9]  L. Wasserman,et al.  Isoagglutinins associated with ABO erythroblastosis. , 1961, The Journal of clinical investigation.

[10]  A. Rawson,et al.  Studies of blood group antibodies. IV. Physicochemical differences between isoanti-A,B and isoanti-A or isoanti-B. , 1960, Journal of immunology.

[11]  A. Rawson,et al.  Studies of Blood Group Antibodies , 1959, The Journal of Immunology.

[12]  A. Rawson,et al.  [Studies of blood group antibodies. I. Fractionation of anti-A and anti-B Isohemagglutinins by anioncation cellulose exchange chromatography]. , 1959, Journal of immunology.

[13]  Kunkel Hg,et al.  Comparative levels of high molecular weight (19S) gamma globulin in maternal and umbilical cord sera. , 1958 .

[14]  W. Zuelzer,et al.  ABO hemolytic disease and heterospecific pregnancy. , 1957, Pediatric clinics of North America.

[15]  M. Svarc,et al.  [Hemolytic disease of the newborn]. , 1952, Medicinski arhiv.

[16]  R. B. Roy,et al.  Erythroblastosis Foetalis Following ABO Incompatibility , 1950 .

[17]  M. Ellis,et al.  AN UNUSUAL CASE OF ERYTHROBLASTOSIS FOETALIS , 1946 .

[18]  I. Halbrecht.  ROLE OF HEMOAGGLUTININS ANTI-A AND ANTI-B IN PATHOGENESIS OF JAUNDICE OF THE NEWBORN (ICTERUS NEONATORUM PRECOX) , 1944 .

[19]  N. Hirschberg.  ISOLATION OF INTESTINAL PATHOGENS FROM PRESERVED STOOLS OF CHILDREN , 1942 .

[20]  S. G. Driscoll.  Hydrops fetalis. , 1966, The New England journal of medicine.

[21]  H. Kunkel,et al.  Comparative levels of high molecular weight (19S) gamma globulin in maternal and umbilical cord sera. , 1958, The Journal of laboratory and clinical medicine.

[22]  R. Rosenfield.  A-B Hemolytic disease of the newborn; analysis of 1480 cord blood specimens, with special reference to the direct antiglobulin test and to the group O mother. , 1955, Blood.

[23]  A. S. Wiener,et al.  Permeability of the human placenta to isoantibodies. , 1946, The Journal of laboratory and clinical medicine.