Aspiration cytology and immunocytochemistry of sacral chordoma with liver metastases: A case report

We present the cytologic features and immunocytochemical profile of a case of sacrococcygeal chordoma metastatic to the liver. Cytologic diagnosis was suspected from the aspiration biopsy smears of the primary sacrococcygeal tumor and confirmed by histology. Further aspirates failed to reveal diagnostic physaliferous cells, and only undifferentiated spindle cells were obtained. Chordoma may lack physaliferous cells; in such cases, immunocytochemistry studies can greatly facilitate the diagnosis. This study confirms the utility of irnmunocytochemistry in the differential diagnosis of chordoma and tumors with similar cytologic characteristics.

[1]  E. Vollmer,et al.  S-100 protein and neuron specific enolase (NSE) expression by chordomas in relation to the composition of their stromal mucosubstances. , 1988, Pathology, research and practice.

[2]  A. A. Giraldo,et al.  Chordoma. An immunohistochemical study of 20 cases. , 1988, Archives of pathology & laboratory medicine.

[3]  V. Mazzaferro,et al.  Chordoma: Natural history and treatment results in 33 cases , 1988, Journal of surgical oncology.

[4]  R. T. Callery,et al.  Cytologic diagnosis of a chordoma without physaliforous cells , 1988, Diagnostic cytopathology.

[5]  H. Autio–Harmainen,et al.  Carcinomatous features of cervical chordoma in a fine needle aspirate. , 1987, Acta cytologica.

[6]  P. Hall,et al.  Diagnosis of cervical chordoma by fine needle aspiration biopsy. , 1987, Acta cytologica.

[7]  J. Salisbury.  Demonstration of cytokeratins and an epithelial membrane antigen in chondroid chordoma , 1987, The Journal of pathology.

[8]  G. Rutherfoord,et al.  Chordomas—ultrastructure and immunohistochemistry: a report based on the examination of six cases , 1987, Histopathology.

[9]  W. Frable,et al.  Chordoma: Diagnosis by fine‐needle aspiration biopsy with histologic, immunocytochemical, and ultrastructural confirmation , 1986, Diagnostic cytopathology.

[10]  R. Sibley,et al.  Chordoma: an immunohistologic study. , 1986, Human pathology.

[11]  I. Ramzy,et al.  Anaplastic sacrococcygeal chordoma. Fine needle aspiration cytologic findings and embryologic considerations. , 1986, Acta cytologica.

[12]  R. Stead,et al.  Chordoma: Cytologic and immunocytochemical study of four cases , 1986, Diagnostic cytopathology.

[13]  N. Sneige,et al.  Ovarian and omental ependymomas in peritoneal washings: Cytologic and immunocytochemical features , 1986, Diagnostic cytopathology.

[14]  J. Salisbury,et al.  Demonstration of cytokeratins and an epithelial membrane antigen in chordomas and human fetal notochord , 1985, The American journal of surgical pathology.

[15]  J. Heaton,et al.  Reflections on notochordal differentiation arising from a study of chordomas , 1985, Histopathology.

[16]  B. Mielke,et al.  Chondroid chordoma of the skull base diagnosed by squash‐smear technique , 1985, Diagnostic cytopathology.

[17]  M. Miettinen.  Chordoma. Antibodies to epithelial membrane antigen and carcinoembryonic antigen in differential diagnosis. , 1984, Archives of pathology & laboratory medicine.

[18]  D. Pritchard,et al.  Clinicopathologic study of sacrococcygeal chordoma , 1984, Cancer.

[19]  R. Giorno.  A comparison of two immunoperoxidase staining methods based on the avidin-biotin interaction. , 1984, Diagnostic immunology.

[20]  F. Enzinger,et al.  Soft tissue tumors , 1988 .

[21]  R. Fulks,et al.  Aspiration cytology of metastatic chordoma. A case report. , 1983, Acta cytologica.

[22]  Schumann Gb,et al.  Aspiration cytology and cytochemistry of coccygeal chordoma. A case report and review of the literature. , 1983 .

[23]  Lefer Lg,et al.  The cytology of chordoma. , 1978 .