ZM336372, A Raf-1 Activator, Causes Suppression of Proliferation in a Human Hepatocellular Carcinoma Cell Line

[1]  Herb Chen,et al.  Overexpression of the NOTCH1 Intracellular Domain Inhibits Cell Proliferation and Alters the Neuroendocrine Phenotype of Medullary Thyroid Cancer Cells* , 2006, Journal of Biological Chemistry.

[2]  Herb Chen,et al.  The Raf-1 pathway: a molecular target for treatment of select neuroendocrine tumors? , 2006, Anti-cancer drugs.

[3]  H. Blum,et al.  Hepatocellular carcinoma: therapy and prevention. , 2005, World journal of gastroenterology.

[4]  Junhong Han,et al.  Hepatocyte Growth Factor Induces Redistribution of p21CIP1 and p27KIP1 through ERK-dependent p16INK4a Up-regulation, Leading to Cell Cycle Arrest at G1 in HepG2 Hepatoma Cells* , 2005, Journal of Biological Chemistry.

[5]  E. Nakakura,et al.  Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling. , 2005, The Journal of clinical endocrinology and metabolism.

[6]  J. V. Van Gompel,et al.  ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells , 2005, Molecular Cancer Therapeutics.

[7]  D. Hedley,et al.  Raf kinase as a target for anticancer therapeutics , 2005, Molecular Cancer Therapeutics.

[8]  Xuetao Cao,et al.  Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. , 2003, Cancer research.

[9]  Herb Chen,et al.  Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells. , 2003, American journal of physiology. Gastrointestinal and liver physiology.

[10]  R. Hruban,et al.  Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. , 2003, Cancer cell.

[11]  C. Cordon-Cardo,et al.  Oncogenes in melanoma , 2003, Oncogene.

[12]  A. Zhu Hepatocellular Carcinoma: Are We Making Progress? , 2003, Cancer investigation.

[13]  Herb Chen,et al.  Activation of the ras/raf-1 signal transduction pathway in carcinoid tumor cells results in morphologic transdifferentiation. , 2002, Surgery.

[14]  F. Brunello,et al.  Elevated serum chromogranin A in patients with hepatocellular carcinoma , 2002, Clinical and Experimental Medicine.

[15]  A. Ullrich,et al.  Molecular cloning and characterization of a novel gene which is highly expressed in hepatocellular carcinoma , 2002, Oncogene.

[16]  K. Miyazawa,et al.  High Intensity ERK Signal Mediates Hepatocyte Growth Factor-induced Proliferation Inhibition of the Human Hepatocellular Carcinoma Cell Line HepG2* , 2001, The Journal of Biological Chemistry.

[17]  A. Saetta,et al.  Morphological-Histochemical study of intestinal carcinoids and K-ras mutation analysis in appendiceal carcinoids , 1999, Pathology & Oncology Research.

[18]  Philip R. Cohen,et al.  Paradoxical activation of Raf by a novel Raf inhibitor. , 1999, Chemistry & biology.

[19]  M. McMahon,et al.  Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells. , 1999, American journal of respiratory cell and molecular biology.

[20]  Takashi Tsuruo,et al.  Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors , 1999, Oncogene.

[21]  E. Lees,et al.  Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1 , 1997, Molecular and cellular biology.

[22]  E. Kaplan,et al.  The presence of K‐12 ras mutations in duodenal adenocarcinomas and the absence of ras mutations in other small bowel adenocarcinomas and carcinoid tumors , 1997, Cancer.

[23]  S. Baylin,et al.  Differentiation of medullary thyroid cancer by C-Raf-1 silences expression of the neural transcription factor human achaete-scute homolog-1. , 1996, Surgery.

[24]  E. Kaplan,et al.  Comparison of mutations of ras oncogene in human pancreatic exocrine and endocrine tumors. , 1993, Surgery.

[25]  S. Baylin,et al.  Introduction of v-Ha-ras oncogene induces differentiation of cultured human medullary thyroid carcinoma cells. , 1987, Proceedings of the National Academy of Sciences of the United States of America.