Controlled delivery of DNA origami on patterned surfaces.

Due to its capacity for programmable self-assembly, wellestablished modes of chemical synthesis, and exceptional stability, DNA serves as a powerful nanoscale structural material. In particular, the recent invention of DNA origami technology has established a paradigm in which DNA’s capacity for deterministic self-assembly into essentially any discrete two-dimensional (2D) shape can be exploited for the construction of molecular ‘‘bread boards’’. For example, previous groups have demonstrated the delivery of nanoparticles to specific positions within an origami scaffold with nanometer-scale precision and the weaving of DNA aptamers into origami for the assembly of protein arrays. However, in order to fully harness the potential of DNA as a universal nanoscale template, it is important not only to control the position of cargo material within the origami scaffold but also to accurately control the position and orientation of the