A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes.

[1]  V. Giguère,et al.  Estrogen-Related Receptor α Directs Peroxisome Proliferator-Activated Receptor α Signaling in the Transcriptional Control of Energy Metabolism in Cardiac and Skeletal Muscle , 2004, Molecular and Cellular Biology.

[2]  R. Evans,et al.  Regulation of Muscle Fiber Type and Running Endurance by PPARδ , 2004, PLoS biology.

[3]  M. Steinmetz,et al.  Malonyl-CoA decarboxylase (MCD) is differentially regulated in subcellular compartments by 5'AMP-activated protein kinase (AMPK). Studies using H9c2 cells overexpressing MCD and AMPK by adenoviral gene transfer technique. , 2004, European journal of biochemistry.

[4]  M. Engelgau,et al.  The Evolving Diabetes Burden in the United States , 2004, Annals of Internal Medicine.

[5]  E. Ojuka Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle , 2004, The Proceedings of the Nutrition Society.

[6]  J. Ju,et al.  UCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction. , 2004, American journal of physiology. Endocrinology and metabolism.

[7]  M. Saad,et al.  Peroxisomal proliferator-activated receptor alpha deficiency diminishes insulin-responsiveness of gluconeogenic/glycolytic/pentose gene expression and substrate cycle flux. , 2004, Endocrinology.

[8]  R. Knutsen,et al.  Dexamethasone induction of hypertension and diabetes is PPAR-α dependent in LDL receptor–null mice , 2003, Nature Medicine.

[9]  M. Daly,et al.  PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes , 2003, Nature Genetics.

[10]  M. Reitman,et al.  Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis. , 2003, Diabetes.

[11]  A. Butte,et al.  Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[12]  Xianlin Han,et al.  A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[13]  C. Kahn,et al.  Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[14]  L. Nolte,et al.  Respiratory Uncoupling Lowers Blood Pressure Through a Leptin-Dependent Mechanism in Genetically Obese Mice , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[15]  C. Kahn,et al.  Insulin signalling and the regulation of glucose and lipid metabolism , 2001, Nature.

[16]  G. Reach,et al.  PPAR-α–Null Mice Are Protected From High-Fat Diet–Induced Insulin Resistance , 2001 .

[17]  Margaret S. Wu,et al.  Role of AMP-activated protein kinase in mechanism of metformin action. , 2001, The Journal of clinical investigation.

[18]  G. Shulman,et al.  Prevention of fat-induced insulin resistance by salicylate. , 2001, The Journal of clinical investigation.

[19]  G. Shulman,et al.  Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[20]  J. Pessin,et al.  Printed in U.S.A. Copyright © 2001 by The Endocrine Society The MEF2A and MEF2D Isoforms Are Differentially Regulated in Muscle and Adipose Tissue during States of Insulin Deficiency* , 2022 .

[21]  C. Semenkovich,et al.  PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice. , 2001, The Journal of clinical investigation.

[22]  P. Puigserver,et al.  Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1 , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[23]  Bruno Derudas,et al.  Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity* , 2000, The Journal of Biological Chemistry.

[24]  J. Pessin,et al.  The MEF2A Isoform Is Required for Striated Muscle-specific Expression of the Insulin-responsive GLUT4 Glucose Transporter* , 2000, The Journal of Biological Chemistry.

[25]  G. Shulman,et al.  On Diabetes: Insulin Resistance Cellular Mechanisms of Insulin Resistance , 2022 .

[26]  W. Wahli,et al.  Peroxisome proliferator-activated receptors: nuclear control of metabolism. , 1999, Endocrine reviews.

[27]  D. Kelly,et al.  A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[28]  W. Wahli,et al.  Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting , 1999 .

[29]  G. Shulman,et al.  Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. , 1999, Diabetes.

[30]  D L Rothman,et al.  Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. , 1999, The Journal of clinical investigation.

[31]  M. Mueckler,et al.  Dissociation of GLUT4 Translocation and Insulin-stimulated Glucose Transport in Transgenic Mice Overexpressing GLUT1 in Skeletal Muscle* , 1998, The Journal of Biological Chemistry.

[32]  D. Kelly,et al.  Activation of a novel metabolic gene regulatory pathway by chronic stimulation of skeletal muscle. , 1996, The American journal of physiology.

[33]  T. Pineau,et al.  Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators , 1995, Molecular and cellular biology.

[34]  B. Lowell,et al.  Development of obesity in transgenic mice after genetic ablation of brown adipose tissue , 1993, Nature.

[35]  K. O'dea,et al.  The Longitudinal Effect of Inhibiting Fatty Acid Oxidation in Diabetic Rats Fed a High Fat Diet , 1992, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[36]  C. Kahn,et al.  Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation. , 1992, The Journal of biological chemistry.

[37]  D. Pessayre,et al.  Inhibition by salicylic acid of the activation and thus oxidation of long chain fatty acids. Possible role in the development of Reye's syndrome. , 1991, The Journal of pharmacology and experimental therapeutics.

[38]  D. Kelly,et al.  The tissue-specific expression and developmental regulation of two nuclear genes encoding rat mitochondrial proteins. Medium chain acyl-CoA dehydrogenase and mitochondrial malate dehydrogenase. , 1989, The Journal of biological chemistry.

[39]  L. Mandarino,et al.  Mechanism of hyperglycemia and response to treatment with an inhibitor of fatty acid oxidation in a patient with insulin resistance due to antiinsulin receptor antibodies. , 1984, The Journal of clinical endocrinology and metabolism.

[40]  T. Kirsch,et al.  Pharmacologic profile of methyl 2-tetradecylglycidate (McN-3716)--an orally effective hypoglycemic agent. , 1978, Metabolism: clinical and experimental.

[41]  E. Newsholme,et al.  The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. , 1963, Lancet.

[42]  David Carling,et al.  The AMP-activated protein kinase cascade--a unifying system for energy control. , 2004, Trends in biochemical sciences.

[43]  W. Wahli,et al.  Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone. , 2004, Journal of lipid research.

[44]  V. Giguère,et al.  Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. , 2004, Molecular and cellular biology.

[45]  Xianlin Han,et al.  The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. , 2002, The Journal of clinical investigation.

[46]  K. O'dea,et al.  Effect of Fatty Acid Oxidation Inhibition on Glucose Metabolism in Diabetic Rats , 1993, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.