Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases.

The human diet contains a great variety of natural mutagens and carcinogens, as well as many natural antimutagens and anticarcinogens. Many of these mutagens and carcinogens may act through the generation of oxygen radicals. Oxygen radicals may also play a major role as endogenous initiators of degenerative processes, such as DNA damage and mutation (and promotion), that may be related to cancer, heart disease, and aging. Dietary intake of natural antioxidants could be an important aspect of the body's defense mechanism against these agents. Many antioxidants are being identified as anticarcinogens. Characterizing and optimizing such defense systems may be an important part of a strategy of minimizing cancer and other age-related diseases.

[1]  R. Macholz Xenobiotics in Foods and Feeds. Herausgegeben von J. W. Finley und D. E. Schwass. 421 Seiten, zahlr. Abb. und Tab. American Chemical Society, Washington, D. C., 1983. Preis: 49.95 $ (USA und Canada); 59.95 $ (Export) , 1984 .

[2]  R. Schoental Health hazards of pyrrolizidine alkaloids: a short review. , 1982, Toxicology letters.

[3]  A. Lurie,et al.  Effects of low-level X-radiation on 7,12-dimethylbenz[a]anthracene-induced lingual tumors in Syrian golden hamsters. , 1979, Journal of the National Cancer Institute.

[4]  D. Jerina,et al.  Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: exceptional activity of ellagic acid. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[5]  L. Ernster,et al.  DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation. , 1982, Archives of biochemistry and biophysics.

[6]  J. Bremer,et al.  Metabolism of very long-chain monounsaturated fatty acids (22:1) and the adaptation to their presence in the diet. , 1982, Journal of lipid research.

[7]  W. Powrie,et al.  Clastogenic activity of caramel and caramelized sugars. , 1981, Mutation research.

[8]  F. Bischoff Carcinogenic effects of steroids. , 1969, Advances in lipid research.

[9]  B. Brunekreef,et al.  Long-term average suspended particulate concentrations in Smokers' homes , 1982, International archives of occupational and environmental health.

[10]  M. Chevion,et al.  A novel method for quantitation of favism-inducing agents in legumes. , 1983, Analytical biochemistry.

[11]  H. Ishiwata,et al.  Separation and determination of macrocyclic pyrrolizidine alkaloids of the otonecine type present in the edible plant Petasites japonicus by reversed-phase high-performance liquid chromatography. , 1983, Journal of chromatography.

[12]  P. Hartge,et al.  Coffee and ovarian cancer , 1982, International journal of cancer.

[13]  M. Banerjee,et al.  Selenium mediated dose-inhibition of 7,12-dimethylbenz[a] anthracene-induced transformation of mammary cells in organ culture. , 1982, Cancer letters.

[14]  N. Dhalla,et al.  Role of free radicals in catecholamine-induced cardiomyopathy. , 1982, Canadian journal of physiology and pharmacology.

[15]  A. Tuyns,et al.  Cancers of the digestive tract, alcohol and tobacco , 1982, International journal of cancer.

[16]  P. Puska,et al.  ASSOCIATION BETWEEN CARDIOVASCULAR DEATH AND MYOCARDIAL INFARCTION AND SERUM SELENIUM IN A MATCHED-PAIR LONGITUDINAL STUDY , 1982, The Lancet.

[17]  A. Gown,et al.  Further investigations of the capacity of polynuclear aromatic hydrocarbons to elicit atherosclerotic lesions. , 1981, Journal of toxicology and environmental health.

[18]  C. Welsch,et al.  Enhancement of murine mammary tumorigenesis by feeding high levels of dietary fat: a hormonal mechanism? , 1983, Journal of the National Cancer Institute.

[19]  Lei Peng,et al.  Can , 1984 .

[20]  L. Bjeldanes,et al.  Mutagens from the cooking of food. II. Survey by Ames/Salmonella test of mutagen formation in the major protein-rich foods of the American diet. , 1982, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[21]  L. Wattenberg,et al.  Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse. , 1982, Cancer research.

[22]  T. Slaga,et al.  Diminution of mouse epidermal superoxide dismutase and catalase activities by tumor promoters. , 1981, Carcinogenesis.

[23]  J. Totter Spontaneous cancer and its possible relationship to oxygen metabolism. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[24]  J. P. Brown,et al.  A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds. , 1980, Mutation research.

[25]  E C Miller,et al.  Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole. , 1983, Cancer research.

[26]  A. Murai,et al.  Structure of Rishitinone, a Valencane Stress Metabolite in Diseased Potato , 1982 .

[27]  B. Halliwell,et al.  INCREASED NON-PROTEIN-BOUND IRON AND DECREASED PROTECTION AGAINST SUPEROXIDE-RADICAL DAMAGE IN CEREBROSPINAL FLUID FROM PATIENTS WITH NEURONAL CEROID LIPOFUSCINOSES , 1982, The Lancet.

[28]  N. Werthessen,et al.  Angiotoxicity of oxygenated sterols and possible precursors. , 1980, Science.

[29]  D. Mourelatos,et al.  Anti-tumour alkylating agents act synergistically with methylxanthines on induction of sister-chromatid exchange in human lymphocytes. , 1982, Mutation research.

[30]  J. Marx Do tumor promoters affect DNA after all? , 1983, Science.

[31]  H. Renner,et al.  Genotoxicity of cocoa examined by microbial and mammalian systems. , 1982, Mutation research.

[32]  H. F. Stich,et al.  Short-Term Tests for Chemical Carcinogens , 1981, Topics in Environmental Physiology and Medicine.

[33]  J. Higginson Cancer and environment: Higginson speaks out. , 1979, Science.

[34]  M. Rajewsky,et al.  Development and possible use of immunological techniques to detect individual exposure to carcinogens: International Agency for Research on Cancer/International Programme on Chemical Safety Working Group Report. , 1982, Cancer research.

[35]  D. Lucido,et al.  Dietary vitamin C and uterine cervical dysplasia. , 1981, American journal of epidemiology.

[36]  C. C. Reddy,et al.  Cadmium, methylmercury, mercury, and lead inhibition of calf liver glutathione S-transferase exhibiting selenium-independent glutathione peroxidase activity. , 1981, Toxicology and applied pharmacology.

[37]  F. Speizer,et al.  Assessment of the epidemiological data relating lung cancer to air pollution. , 1983, Environmental health perspectives.

[38]  J. Haseman,et al.  Carcinogenesis bioassay of allyl isothiocyanate. , 1982, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[39]  H. Black,et al.  A model system for the evaluation of the role of cholesterol -oxide in ultraviolet carcinogenesis. , 1972, Cancer research.

[40]  E. Abel Consumption of alcohol during pregnancy: a review of effects on growth and development of offspring. , 1982, Human biology.

[41]  V. O. Mora-Arellano,et al.  Free radicals and singlet oxygen scavengers: reaction of a peroxy-radical with beta-carotene, diphenyl furan and 1,4-diazobicyclo (2,2,2)-octane. , 1981, Biochemical and biophysical research communications.

[42]  J. Heddle Mutagenicity, new horizons in genetic toxicology , 1982 .

[43]  M. Rosin,et al.  Quantitating the synergistic effect of smoking and alcohol consumption with the micronucleus test on human buccal mucosa cells , 1983, International journal of cancer.

[44]  B. Tóth,et al.  Gastric tumorigenesis by a single dose of 4-(hydroxymethyl)benzenediazonium ion of Agaricus bisporus. , 1982, British Journal of Cancer.

[45]  L. Pauling,et al.  Effects of intake of L-ascorbic acid on the incidence of dermal neoplasms induced in mice by ultraviolet light. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[46]  H. Bernstein,et al.  DNA Damage as the Primary Cause of Aging , 1981, The Quarterly Review of Biology.

[47]  S. Urasawa,et al.  Genotoxicity of flavoring agents. , 1982, Mutation research.

[48]  R. A. Neal,et al.  Biotransformation of phenol to hydroquinone and catechol by rat liver microsomes. , 1983, Molecular pharmacology.

[49]  R. Mason,et al.  CHAPTER 6 – Free-Radical Intermediates in the Metabolism of Toxic Chemicals , 1982 .

[50]  T. Hirayama Diet and cancer , 1979 .

[51]  R. Lambert,et al.  Wine and tobacco: risk factors for gastric cancer in France. , 1981, American journal of epidemiology.

[52]  T. Sugimura,et al.  Environmental mutagens and carcinogens. , 1978, Annual review of genetics.

[53]  B. Ames,et al.  Concentration of mutagens from urine by absorption with the nonpolar resin XAD-2: cigarette smokers have mutagenic urine. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[54]  I. Weinstein Tumour promoters:Protein kinase, phospholipid and control of growth , 1983, Nature.

[55]  B Chance,et al.  Hydroperoxide metabolism in mammalian organs. , 1979, Physiological reviews.

[56]  C. Scoggin,et al.  Hydrogen peroxide causes the fatal injury to human fibroblasts exposed to oxygen radicals. , 1981, The Journal of biological chemistry.

[57]  I. Emerit,et al.  Activated oxygen species at the origin of chromosome breakage and sister-chromatid exchanges. , 1982, Mutation research.

[58]  I. Emerit,et al.  Suppression of tumor promoter phorbolmyristate acetate-induced chromosome breakage by antioxidants and inhibitors of arachidonic acid metabolism. , 1983, Mutation research.

[59]  T. Slaga,et al.  Inhibition of mouse skin tumor promotion by several inhibitors of arachidonic acid metabolism. , 1982, Carcinogenesis.

[60]  W. Willett,et al.  PREDIAGNOSTIC SERUM SELENIUM AND RISK OF CANCER , 1983, The Lancet.

[61]  I. Weinstein The monitoring of DNA adducts as an approach to carcinogen detection. , 1983, Annual review of public health.

[62]  S. Venitt Mutagenicity—New Horizons in Genetic Toxicology , 1983, British Journal of Cancer.

[63]  J. Warren,et al.  HEPATIC AND RENAL EFFECTS OF PEROXISOME PROLIFERATORS: BIOLOGICAL IMPLICATIONS * , 1982, Annals of the New York Academy of Sciences.

[64]  N. Brot,et al.  Lens methionine sulfoxide reductase. , 1982, Biochemical and biophysical research communications.

[65]  L. Flohé CHAPTER 7 – Glutathione Peroxidase Brought into Focus , 1982 .

[66]  T. Suga,et al.  Changes in peroxisomal fatty acid oxidation in the diabetic rat liver. , 1981, Journal of biochemistry.

[67]  W. Pryor Free Radicals in Biology , 1976 .

[68]  J. Barrett,et al.  Tumour promoters induce mitotic aneuploidy in yeast , 1981, Nature.

[69]  G. Brooks,et al.  Free radicals and tissue damage produced by exercise. , 1982, Biochemical and biophysical research communications.

[70]  A. Awad Trans Fatty Acids in Tumor Development: Reply , 1982 .

[71]  C. Goin,et al.  Induction of mitotic recombination by certain hair-dye chemicals in Saccharomyces cerevisiae. , 1980, Mutation research.

[72]  H. L. Plaine The Effect of Oxygen and of Hydrogen Peroxide on the Action of a Specific Gene and on Tumor Induction in Drosophila Melanogaster. , 1955, Genetics.

[73]  R. Laine,et al.  Factors affecting the elicitation of sesquiterpenoid phytoalexin accumulation by eicosapentaenoic and arachidonic acids in potato. , 1982, Plant physiology.

[74]  H. Birnboim Factors which affect DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate. , 1982, Canadian journal of physiology and pharmacology.

[75]  A. M. Pearson,et al.  Effects of dietary fat and vitamin E on the liquid composition and stability of veal during frozen storage. , 1981, Journal of agricultural and food chemistry.

[76]  W. Powrie,et al.  Chapter 5 – The Use of Mutagenicity Testing to Evaluate Food Products , 1982 .

[77]  Anthony M. Guarino Toxic Constituents of Plant Foodstuffs. Irvin E. Liener, Ed. Academic Press, New York, 1969. xvi + 504 pp., illus. $20. Food Science and Technology, vol. 6 , 1969 .

[78]  I. Berenblum,et al.  The effect of caffeine on two-stage skin carcinogenesis and on complete systemic carcinogenesis. , 1981, Carcinogenesis.

[79]  A. Murai,et al.  Structure of Epilubimin, Epioxylubimin, and Isolubimin, Spirovetivane Stress Metabolites in Diseased Potato , 1982 .

[80]  J. Strong,et al.  Atherosclerosis and polyps of the colon. Quantification of precursors of coronary heart disease and colon cancer. , 1982, Journal of chronic diseases.

[81]  D. Kritchevsky,et al.  Influence of trans unsaturated fats on experimental atherosclerosis in rabbits. , 1983, The Journal of nutrition.

[82]  M. Mathews-Roth Photosensitization by porphyrins and prevention of photosensitization by carotenoids. , 1982, Journal of the National Cancer Institute.

[83]  M. M. Jacobs Selenium inhibition of 1,2-dimethylhydrazine-induced colon carcinogenesis. , 1983, Cancer research.

[84]  R. Hoover,et al.  Esophageal cancer among black men in Washington, D.C. II. Role of nutrition. , 1981, Journal of the National Cancer Institute.

[85]  B. Ames,et al.  Detection of mutagenic activity in cigarette smoke condensates. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[86]  J. Casida,et al.  Toxaphene, a complex mixture of polychloroterpenes and a major insecticide, is mutagenic. , 1979, Science.

[87]  B. Tóth,et al.  Evidence for the occurrence and formation of diazonium ions in the Agaricus bisporus mushroom and its extracts. , 1982, Journal of agricultural and food chemistry.

[88]  L. Oberley,et al.  The role of oxygen-derived free radicals in radiation-induced damage and death of nondividing eucaryotic cells. , 1980, Radiation research.

[89]  J. Prebble,et al.  Protection of cell viability and respiratory quinone levels by carotenoid in Micrococcus lysodeikticus (M. luteus). , 1980, Journal of general microbiology.

[90]  S. Wolff,et al.  Induction of sister-chromatid exchanges in human lymphocytes by microsomal activation of benzene metabolites. , 1983, Mutation research.

[91]  E. Klekowski Environmental Mutagenesis, Carcinogenesis and Plant Biology , 1982 .

[92]  F. Serres,et al.  CHEMICAL MUTAGENS: PRINCIPLES AND METHODS FOR THEIR DETECTION , 1972 .

[93]  W. Powrie,et al.  Induction of mitotic gene conversion by browning reaction products and its modulation by naturally occurring agents. , 1982, Mutation research.

[94]  G. Stoewsand,et al.  Modification of beet and cabbage diets of aflatoxin B1-induced rat plasma alpha-foetoprotein elevation, hepatic tumorigenesis, and mutagenicity of urine. , 1982, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[95]  T. Slaga,et al.  Promotion of carcinomas by repeated abrasion in initiated skin of mice. , 1981, Cancer research.

[96]  W. Pryor,et al.  The radicals in cigarette tar: their nature and suggested physiological implications. , 1983, Science.

[97]  Rebecca Rawls Dioxin's Human Toxicity Is Most Difficult Problem: Dioxin is extremely toxic to certain animals, but scientists are only beginning to understand the nature of its toxicity and exactly what it does to humans , 1983 .

[98]  K J Rothman,et al.  Interaction of alcohol and tobacco in laryngeal cancer. , 1982, American journal of epidemiology.

[99]  W. Powrie,et al.  The action of transition metals on the genotoxicity of simple phenols, phenolic acids and cinnamic acids. , 1981, Cancer letters.

[100]  Y. Ito,et al.  A new view of the etiology of nasopharyngeal carcinoma. , 1981, Preventive medicine.

[101]  W. Powrie,et al.  A comparative genotoxicity study of chlorogenic acid (3-0-caffeoylquinic acid). , 1981, Mutation research.

[102]  I. Emerit,et al.  Tumor promoter phorbol 12-myristate 13-acetate induces a clastogenic factor in human lymphocytes. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[103]  S. Latt,et al.  Stimulated human phagocytes produce cytogenetic changes in cultured mammalian cells. , 1983, The New England journal of medicine.

[104]  P. Hartman Nitrates and Nitrites: Ingestion, Pharmacodynamics, and Toxicology , 1982 .

[105]  A. Kinsella Elimination of metabolic co-operation and the induction of sister chromatid exchanges are not properties common to all promoting or co-carcinogenic agents. , 1982, Carcinogenesis.

[106]  H. Cuckle,et al.  Coffee and cancer of the pancreas. , 1981, British Journal of Cancer.

[107]  C. Borek,et al.  Modifiers of free radicals inhibit in vitro the oncogenic actions of x-rays, bleomycin, and the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[108]  J. Pitts Formation and fate of gaseous and particulate mutagens and carcinogens in real and simulated atmospheres. , 1983, Environmental health perspectives.

[109]  Mutagenicity of Maillard browning products obtained from a starch--glycine model system. , 1981, Food and cosmetics toxicology.

[110]  H. Stich,et al.  Inhibitory effects of phenolics, teas and saliva on the formation of mutagenic nitrosation products of salted fish , 1982, International journal of cancer.

[111]  C. Chichester,et al.  Metabolism and nutritional significance of carotenoids. , 1981, Annual review of nutrition.

[112]  T. Higashi,et al.  Relative contributions of sulfur atoms of dietary cysteine and methionine to rat liver glutathione and proteins. , 1981, Journal of biochemistry.

[113]  A. Novi Regression of aflatoxin B1-induced hepatocellular carcinomas by reduced glutathione. , 1981, Science.

[114]  J. Koeman,et al.  Mutagenicity of extracts of some vegetables commonly consumed in the Netherlands. , 1983, Journal of agricultural and food chemistry.

[115]  T. Kensler,et al.  Inhibiton of phorbol ester-stimulated chemiluminescence in human polymorphonuclear leukocytes by retinoic acid and 5,6-epoxyretinoic acid. , 1981, Cancer research.

[116]  V. Hubbard,et al.  Medical uses of vitamin E. , 1983, The New England journal of medicine.

[117]  P. Hartman Review: putative mutagens and carcinogens in foods. I. Nitrate/nitrite ingestion and gastric cancer mortality. , 1983, Environmental mutagenesis.

[118]  D. Angus,et al.  Detection of mutagenic activity in human urine following fried pork or bacon meals. , 1982, Cancer letters.

[119]  I. Hirono,et al.  Natural carcinogenic products of plant origin. , 1981, Critical reviews in toxicology.

[120]  J. M. Concon,et al.  Black pepper [piper nigrum]: Evidence of carcinogenicity , 1979 .

[121]  S. Stohs,et al.  Lipid peroxidation as a possible cause of TCDD toxicity. , 1983, Biochemical and biophysical research communications.

[122]  E. Bardana,et al.  Systemic lupus erythematosus-like syndrome in monkeys fed alfalfa sprouts: role of a nonprotein amino acid. , 1982, Science.

[123]  J. Ebel,et al.  Phytoalexins, Chemical Defense Substances of Higher Plants? , 1978 .

[124]  L. Videla,et al.  Liver lipoperoxidative pressure and glutathione status following acetaldehyde and aliphatic alcohols pretreatments in the rat. , 1982, Biochemical and biophysical research communications.

[125]  L. Kinlen Fat and cancer. , 1983, British medical journal.

[126]  S. Friedlander,et al.  Relating particulate pollution to sources: the 1972 California aerosol characterization study. , 1975, Atmospheric environment.

[127]  G. Speit,et al.  Characterization of sister chromatid exchange induction by hydrogen peroxide. , 1982, Environmental mutagenesis.

[128]  B. Ames,et al.  A new Salmonella tester strain (TA102) with A X T base pairs at the site of mutation detects oxidative mutagens. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[129]  S. Varma,et al.  PHOTOPEROXIDATION OF LENS LIPIDS: PREVENTION BY VITAMIN E , 1982, Photochemistry and photobiology.

[130]  R. Beier,et al.  HPLC analysis of linear furocoumarins (psoralens) in healthy celery (Apium graveolens). , 1983, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[131]  J. Miquel,et al.  Is cell aging caused by respiration-dependent injury to the mitochondrial genome? , 1982, Gerontology.

[132]  H. Stich,et al.  Clastogenic activity of caffeic acid and its relationship to hydrogen peroxide generated during autooxidation. , 1983, Mutation research.

[133]  D. Birt,et al.  Inhibition by dietary selenium of colon cancer induced in the rat by bis(2-oxopropyl)nitrosamine. , 1982, Cancer research.

[134]  L. Oberley,et al.  Cell differentiation, aging and cancer: the possible roles of superoxide and superoxide dismutases. , 1980, Medical hypotheses.

[135]  J. Vena Air pollution as a risk factor in lung cancer. , 1982, American journal of epidemiology.

[136]  Jeremiah Stamler,et al.  DIETARY VITAMIN A AND RISK OF CANCER IN THE WESTERN ELECTRIC STUDY , 1981, The Lancet.

[137]  M. Sporn,et al.  Can dietary beta-carotene materially reduce human cancer rates? , 1981, Nature.

[138]  R. L. Hall Naturally occurring toxicants and food additives: Our perception and management of risks , 1978 .

[139]  V. Feron,et al.  Respiratory tract tumours in hamsters exposed to acetaldehyde vapour alone or simultaneously to benzo(a)pyrene or diethylnitrosamine. , 1982, European journal of cancer & clinical oncology.

[140]  J R Gillette,et al.  Acetaminophen-induced hepatotoxicity. , 1981, Life sciences.

[141]  O. Glatt MUTAGENS IN OUR ENVIRONMENT , 1965, Journal of the American Geriatrics Society.

[142]  S. Natori,et al.  Mutagenicity of anthraquinones in the Salmonella preincubation test. , 1983, Mutation research.

[143]  T. Slaga,et al.  Specificity and mechanism(s) of promoter inhibitors in multistage promotion. , 1982, Carcinogenesis; a comprehensive survey.

[144]  N. Krinsky,et al.  Interaction of oxygen and oxy-radicals with carotenoids. , 1982, Journal of the National Cancer Institute.

[145]  B. Ames,et al.  Fecalase: a model for activation of dietary glycosides to mutagens by intestinal flora. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[146]  B. Macmahon Risk factors for cancer of the pancreas. , 1982, Cancer.

[147]  J. Hendricks,et al.  Hepatocarcinogenicity of glandless cottonseeds and cottonseed oil to rainbow trout (Salmo gairdnerii). , 1980, Science.

[148]  D. Gardner,et al.  Stimulation of oxidant production in alveolar macrophages by pollutant and latex particles. , 1980, Environmental research.

[149]  A. Varshavsky Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: Possible mechanisms and relevance to tumor promotion , 1981, Cell.

[150]  B. Goldstein,et al.  Stimulation of human polymorphonuclear leukocyte superoxide anion radical production by tumor promoters. , 1981, Cancer letters.

[151]  P. Magee Nitrosamines and human cancer , 1982 .

[152]  A. P. Autor Pathology of oxygen , 1982 .

[153]  T. Kamada,et al.  Lipid peroxidation in alcoholic liver disease in man. , 1981, Advances in experimental medicine and biology.

[154]  E. Mimnaugh,et al.  Activation of pharmacologic agents to radical intermediates. Implications for the role of free radicals in drug action and toxicity. , 1982, Biochemical pharmacology.

[155]  R. Schneider,et al.  Tumours and hormonal changes produced in rats by subcutaneous injections of linoletic acid hydroperoxide. , 1974, Food and cosmetics toxicology.

[156]  S. Walter,et al.  Coffee drinking and bladder cancer in Connecticut. , 1983, American journal of epidemiology.

[157]  Mutagenic activity of hymenovin in Salmonella typhimurium: association with the bishemiacetal functional group. , 1978, Toxicology and applied pharmacology.

[158]  T. Höfer,et al.  Selenium in the testis of the rat: studies on its regulation and its importance for the organism. , 1982, The Journal of nutrition.

[159]  N. Petrakis,et al.  Cholesterol and cholesterol epoxides in nipple aspirates of human breast fluid. , 1981, Cancer research.

[160]  B. Halliwell Production of superoxide, hydrogen peroxide and hydroxyl radicals by phagocytic cells: a cause of chronic inflammatory disease? , 1982, Cell biology international reports.

[161]  D. Comings Metabolic basis of inherited disease , 1983 .

[162]  J. Eys,et al.  Molecular Interrelations of Nutrition and Cancer , 1982 .

[163]  H. Tsuda Chromosomal aberrations induced by hydrogen peroxide in cultured mammalian cells , 1981 .

[164]  T. Slaga,et al.  Effects of peroxides on rodent skin: epidermal hyperplasia and tumor promotion. , 1982, The Journal of investigative dermatology.

[165]  T. Sugimura,et al.  Chapter 3 – The Use of Mutagenicity to Evaluate Carcinogenic Hazards in Our Daily Lives , 1982 .

[166]  S. Hecht,et al.  Quantitative analysis of catechol and 4-methylcatechol in human urine. , 1982, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[167]  E. Dratz,et al.  Effects of antioxidant nutrient deficiency on the retina and retinal pigment epithelium of albino rats: a light and electron microscopic study. , 1982, Experimental eye research.

[168]  S. Orrenius,et al.  Metabolism of hydrogen peroxide in isolated hepatocytes: relative contributions of catalase and glutathione peroxidase in decomposition of endogenously generated H2O2. , 1981, Archives of biochemistry and biophysics.

[169]  M. Thomassen,et al.  Effects of high-fat diets on hepatic fatty acid oxidation in the rat. Isolation of rat liver peroxisomes by vertical-rotor centrifugation by using a self-generated, iso-osmotic, Percoll gradient. , 1981, The Biochemical journal.

[170]  C. Beckman,et al.  Modification of radiation-induced sex-linked recessive lethal mutation frequency by tocopherol. , 1982, Mutation research.

[171]  R. Anderson,et al.  Ethanol-induced male infertility: impairment of spermatozoa. , 1983, The Journal of pharmacology and experimental therapeutics.

[172]  R. Peto Detection of risk of cancer to man , 1979, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[173]  J. H. Gans Dietary influences on theobromine-induced toxicity in rats. , 1982, Toxicology and applied pharmacology.

[174]  R. Bird,et al.  Effect of malonaldehyde and acetaldehyde on cultured mammalian cells. Production of micronuclei and chromosomal aberrations. , 1982, Mutation research.

[175]  R. Cutler,et al.  Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[176]  Hunter Je Trans fatty acids in tumor development. , 1982 .

[177]  A. Fantel,et al.  Teratogenicity of acetaldehyde invitro: Relevance to the fatal alcohol syndrome , 1983 .

[178]  R. Czerniak,et al.  Naturally occurring quinones as potential bioreductive alkylating agents , 1981, Medicinal research reviews.

[179]  M. Fox Naturally Occurring Carcinogens, Mutagens and Modulators of Carcinogenesis , 1980, British Journal of Cancer.

[180]  J. Hatcher,et al.  Quercetin, a rat intestinal and bladder carcinogen present in bracken fern (Pteridium aquilinum). , 1980, Cancer research.

[181]  G. W. Ivie,et al.  Natural toxicants in human foods: psoralens in raw and cooked parsnip root. , 1981, Science.

[182]  R. Huxtable Herbal Teas and Toxins: Novel Aspects of Pyrrolizidine Poisoning in the United States , 2015, Perspectives in biology and medicine.

[183]  B. Zuckerman,et al.  Patterns of Alcohol Consumption and Fetal Development , 1983, Obstetrics and gynecology.

[184]  D. Trichopoulos,et al.  Coffee and ovarian cancer , 1981, International journal of cancer.

[185]  H. Osmundsen Factors which can influence beta-oxidation by peroxisomes isolated from livers of clofibrate treated rats. Some properties of peroxisomal fractions isolated in a self-generated Percoll gradient by vertical rotor centrifugation. , 1982, The International journal of biochemistry.

[186]  R. J. Evans,et al.  A REVIEW OF CYCLOPROPENOID COMPOUNDS: BIOLOGICAL EFFECTS OF SOME DERIVATIVES. , 1965, Poultry science.

[187]  L. Levine,et al.  α-Tocopherol inhibits 12−O-tetradecanoylphorbol-13-acetate-stimulated deacylation of cellular lipids, prostaglandin production, and changes in cell morphology of madin-darby canine kidney cells , 1980 .

[188]  M. Mathews-Roth Antitumor Activity of β-Carotene, Canthaxanthin and Phytoene , 1982 .

[189]  C. Ioannides,et al.  Safrole: its metabolism, carcinogenicity and interactions with cytochrome P-450. , 1981, Food and cosmetics toxicology.

[190]  R. Charlson,et al.  Molecular composition of secondary aerosol and its possible origin , 1975 .

[191]  B. Mannervik,et al.  Purification of a new glutathione S-transferase (transferase μ) from human liver having high activity with benzo(α)pyrene-4,5-oxide , 1981 .

[192]  I. Emerit,et al.  Tumour promoter phorbol-12-myristate-13-acetate induces chromosomal damage via indirect action , 1981, Nature.

[193]  B. Ames,et al.  Identifying environmental chemicals causing mutations and cancer. , 1979, Science.

[194]  B. Henderson,et al.  Bladder cancer etiology: A different perspective , 1983, Cancer.

[195]  A. Cederbaum,et al.  A correlation between hydroxyl radical generation and ethanol oxidation by liver, lung and kidney microsomes. , 1982, Biochemical pharmacology.

[196]  J. Little,et al.  Factors influencing the induction of sister chromatid exchanges in mammalian cells by 12-O-tetradecanoyl-phorbol-13-acetate. , 1981, Carcinogenesis.

[197]  M. Thomassen,et al.  Characterization of the stimulatory effect of high-fat diets on peroxisomal beta-oxidation in rat liver. , 1982, The Biochemical journal.

[198]  N. Artman The chemical and biological properties of heated and oxidized fats. , 1969, Advances in lipid research.

[199]  P. McNamara,et al.  Effect of dietary vitamin E on dimethylhydrazine-induced colonic tumors in mice. , 1980, Cancer research.

[200]  A. Meister,et al.  Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[201]  A. Tauber The human neutrophil oxygen armory , 1982 .

[202]  P. McCay,et al.  Lipid peroxidation and alteration of membrane lipids in isolated hepatocytes exposed to carbon tetrachloride. , 1976, The Journal of biological chemistry.

[203]  J. Gart,et al.  Dietary habits and lung cancer risk , 1983, International journal of cancer.

[204]  B. Ames,et al.  LIPID PEROXIDATION AND OXIDATIVE DAMAGE TO DNA1 , 1982 .

[205]  L. Meeker,et al.  Effect of short-term feeding of sodium selenite on 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in the rat. , 1982, Cancer research.

[206]  E. Speckmann,et al.  Diet, nutrition, and cancer. , 1976, The American journal of clinical nutrition.

[207]  T. Flatmark,et al.  Effects of marine oil diet on peroxisomes and mitochondria of rat liver. A combined biochemical and morphometric study. , 1981, European journal of cell biology.

[208]  A. Krasnovsky,et al.  Dark Oxidation of Unsaturated Lipids by the Photoxidized 8-Methoxypsoralen , 1982, Zeitschrift fur Naturforschung. Section C, Biosciences.

[209]  D. K. Salunkhe,et al.  Naturally occurring toxic alkaloids in foods. , 1981, Critical reviews in toxicology.

[210]  G. Obe,et al.  Influence of chronic ethanol uptake and acute acetaldehyde treatment on the chromosomes of bone-marrow cells and peripheral lymphocytes of Chinese hamsters. , 1981, Mutation research.

[211]  J. Sullivan Superoxide dismutase, longevity and specific metabolic rate. , 1982, Gerontology.

[212]  B. Ames,et al.  Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. , 1981, Proceedings of the National Academy of Sciences of the United States of America.