Clinical Studies of the Interaction between d-Tubocurarine and Succinylcholine

Succinylcholine and d-tubocurarine were given to patients during the administration of general anesthesia in order to test their interaction, d- Tubocurarinc given prior to full recovery from succinylcholine showed no significant change in mean duration of action, but did show a significant decrease in intensity of block. Succinylcholine given after a small dose of d-tubocurarine had a significantly diminished duration and a significantly decreased intensity of block. Succinylcholine after a prolonged block with d-tubocurarine generally reversed the block, while the succinylcholine had a diminished action. One patient developed a prolonged desensitization block after receiving succinylcholine, 52 mg, during a partial d-tubocurarine block.