A metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hypertension
暂无分享,去创建一个
Sotirios D. Zervopoulos | E. Michelakis | P. Dromparis | J. Nagendran | A. Haromy | R. Paulin | G. Sutendra
[1] M. S. Mcmurtry,et al. Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer , 2013, Oncogene.
[2] James D. Thomas,et al. Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year. , 2013, Annals of the American Thoracic Society.
[3] J. Bigbee,et al. Metabolic Gene Remodeling and Mitochondrial Dysfunction in Failing Right Ventricular Hypertrophy Secondary to Pulmonary Arterial Hypertension , 2013, Circulation. Heart failure.
[4] L. Farkas,et al. The monocrotaline model of pulmonary hypertension in perspective. , 2012, American journal of physiology. Lung cellular and molecular physiology.
[5] Nico Westerhof,et al. Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy. , 2011, Journal of the American College of Cardiology.
[6] M. S. Mcmurtry,et al. Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension , 2011, Journal of Molecular Medicine.
[7] W. Sessa,et al. The Role of Nogo and the Mitochondria–Endoplasmic Reticulum Unit in Pulmonary Hypertension , 2011, Science Translational Medicine.
[8] N. Voelkel,et al. Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats. , 2010, American journal of respiratory and critical care medicine.
[9] E. Michelakis,et al. The role of mitochondria in pulmonary vascular remodeling , 2010, Journal of Molecular Medicine.
[10] G. Lopaschuk,et al. Fatty Acid Oxidation and Malonyl-CoA Decarboxylase in the Vascular Remodeling of Pulmonary Hypertension , 2010, Science Translational Medicine.
[11] E. Ashley,et al. New insights for the diagnosis and management of right ventricular failure, from molecular imaging to targeted right ventricular therapy , 2010, Current opinion in cardiology.
[12] C. Long,et al. Chronic Pulmonary Artery Pressure Elevation Is Insufficient to Explain Right Heart Failure , 2009, Circulation.
[13] Kevin M. Ryan,et al. p53 and metabolism , 2009, Nature Reviews Cancer.
[14] Justin R. Cross,et al. ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation , 2009, Science.
[15] Kohtaro Abe,et al. The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension. , 2009, Chest.
[16] I. Haber,et al. The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle , 2009, Journal of Molecular Medicine.
[17] N. Denko,et al. Hypoxia, HIF1 and glucose metabolism in the solid tumour , 2008, Nature Reviews Cancer.
[18] J. Dyck,et al. A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted. , 2008, The Journal of thoracic and cardiovascular surgery.
[19] Yi Tang,et al. Acetylation Is Indispensable for p53 Activation , 2008, Cell.
[20] S. Hunt,et al. Right Ventricular Function in Cardiovascular Disease, Part II: Pathophysiology, Clinical Importance, and Management of Right Ventricular Failure , 2008, Circulation.
[21] S. Hunt,et al. Right Ventricular Function in Cardiovascular Disease, Part I: Anatomy, Physiology, Aging, and Functional Assessment of the Right Ventricle , 2008, Circulation.
[22] W. Kaelin. Faculty Opinions recommendation of Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. , 2008 .
[23] I. Komuro,et al. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload , 2007, Nature.
[24] Sébastien Bonnet,et al. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. , 2007, Cancer cell.
[25] D. Srivastava. Making or Breaking the Heart: From Lineage Determination to Morphogenesis , 2006, Cell.
[26] J. Nyengaard,et al. The total length of myocytes and capillaries, and total number of myocyte nuclei in the rat heart are time-dependently increased by growth hormone. , 2005, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
[27] Y. Kagaya,et al. Increased [18F]fluorodeoxyglucose accumulation in right ventricular free wall in patients with pulmonary hypertension and the effect of epoprostenol. , 2005, Journal of the American College of Cardiology.
[28] P. Schumacker,et al. Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. , 2005, Cell metabolism.
[29] Massimo Zeviani,et al. Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. , 2005, Cell metabolism.
[30] M. Lerman,et al. DNA Damage Is a Prerequisite for p53-Mediated Proteasomal Degradation of HIF-1α in Hypoxic Cells and Downregulation of the Hypoxia Marker Carbonic Anhydrase IX , 2004, Molecular and Cellular Biology.
[31] D. Mccrory,et al. Prognosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. , 2004, Chest.
[32] B. Brüne,et al. p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1). , 2004, The Biochemical journal.
[33] Ling Song,et al. Glycogen Synthase Kinase-3β (GSK3β) Binds to and Promotes the Actions of p53* , 2003, Journal of Biological Chemistry.
[34] J. Yoshikawa,et al. Carvedilol inhibits pressure-induced increase in oxidative stress in coronary smooth muscle cells. , 2002, Hypertension research : official journal of the Japanese Society of Hypertension.
[35] H. Morita,et al. Carvedilol Decreases Elevated Oxidative Stress in Human Failing Myocardium , 2002, Circulation.
[36] J. Sandoval,et al. Right ventricular ischemia in patients with primary pulmonary hypertension. , 2001, Journal of the American College of Cardiology.
[37] W. Dai,et al. Reactive Oxygen Species-induced Phosphorylation of p53 on Serine 20 Is Mediated in Part by Polo-like Kinase-3* , 2001, The Journal of Biological Chemistry.
[38] Y. Rojanasakul,et al. Vanadate Induces p53 Transactivation through Hydrogen Peroxide and Causes Apoptosis* , 2000, The Journal of Biological Chemistry.
[39] Xianglin Shi,et al. The role of hydroxyl radical as a messenger in Cr(VI)-induced p53 activation. , 2000, American journal of physiology. Cell physiology.
[40] F. Muders,et al. Animal models of chronic heart failure. , 2000, Pharmacological research.
[41] G. Semenza,et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. , 2000, Genes & development.
[42] J. Conte,et al. Increased p53 protein expression in human failing myocardium. , 1999, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
[43] J. Caro,et al. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. , 1997, The Journal of biological chemistry.
[44] D. Livingston,et al. Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit* , 1996, The Journal of Biological Chemistry.
[45] K. M. Popov,et al. Diversity of the Pyruvate Dehydrogenase Kinase Gene Family in Humans * , 1995, The Journal of Biological Chemistry.
[46] G. Semenza,et al. Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1. , 1995, Biochemical and biophysical research communications.
[47] R. Ferrari,et al. Noradrenaline, atrial natriuretic peptide, bombesin and neurotensin in myocardium and blood of rats in congestive cardiac failure. , 1989, Cardiovascular research.
[48] S. Bishop,et al. Increased glycolytic metabolism in cardiac hypertrophy and congestive failure. , 1970, The American journal of physiology.