Growth Without Growth Hormone Receptor: Estradiol Is a Major Growth Hormone‐Independent Regulator of Hepatic IGF‐I Synthesis

The role of estrogens in the regulation of pubertal growth independently of GH and its receptor was studied in male mice with disrupted GHRKO. E2 rescued skeletal growth rates in GHRKO associated with an increase in hepatic and serum IGF‐I. These data show that E2 rescues pubertal growth during GH resistance through a novel mechanism of GHR‐independent stimulation of hepatic IGF‐I production.

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