Effect of inhibition of prostaglandin synthesis on epinephrine-induced gastroduodenal electromechanical changes in humans.

We conducted a double-blind randomized study to investigate the role of endogenous prostaglandins in epinephrine-induced changes in human gastric electromechanical activity. Intravenous administration of a pharmacologic dosage of epinephrine (222 ng/kg per min) caused gastric dysrhythmia in 8 of 12 healthy subjects. After indomethacin treatment, the incidence of epinephrine-induced gastric dysrhythmia was reduced to 4 of 12 healthy subjects, which is similar to the incidence of gastric dysrhythmia noted in the placebo group. The difference, however, was not statistically significant (P = 0.2). Epinephrine also substantially inhibited both the amplitude and the frequency of antral contractions. Indomethacin treatment partially reversed the reduction in the amplitude but not the frequency of antral contractions. These results suggest that endogenous prostaglandins may, in part, regulate the amplitude of human antral contractions; however, the role of prostaglandins in epinephrine-induced gastric dysrhythmia in humans remains uncertain.