Tigecycline treatment of multi‐drug‐resistant Corynebacterium jeikeium infection in a child with relapsing and refractory acute lymphoblastic leukemia

Corynebacterium jeikeium has been recognized as an important cause of infection, particularly among neutropenic patients who have central venous catheter (CVC). Routine use of tigecycline in children is not yet approved. Here in we present a child with relapsed‐refractory lymphoblastic leukemia who was successfully treated with tigecyline due to multi‐drug‐resistant C. jeikeium sepsis without removal of CVC. Our case highlights the use of tigecycline where there are no alternatives. Further studies regarding the efficacy and safety of tigecycline in pediatric patients are needed. Pediatr Blood Cancer. 2010;55:349–351. © 2010 Wiley–Liss, Inc.

[1]  Arthur J. L. Cooper,et al.  Safety and efficacy of intravenous tigecycline in subjects with secondary bacteremia: pooled results from 8 phase III clinical trials. , 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[2]  S. Browd,et al.  Multidrug-resistant Enterococcus faecium meningitis in a toddler: characterization of the organism and successful treatment with intraventricular daptomycin and intravenous tigecycline. , 2009, The Pediatric infectious disease journal.

[3]  M. Falagas,et al.  Tigecycline for the treatment of patients with community-acquired pneumonia requiring hospitalization , 2009, Expert review of anti-infective therapy.

[4]  G. Meckler,et al.  Fever and neutropenia in pediatric patients with cancer. , 2009, Emergency medicine clinics of North America.

[5]  K. Rolston,et al.  Tigecycline Use in Cancer Patients With Serious Infections: A Report on 110 Cases From a Single Institution , 2009, Medicine.

[6]  H. Einsele,et al.  Life-Threatening Infection Caused by Daptomycin-Resistant Corynebacterium jeikeium in a Neutropenic Patient , 2009, Journal of Clinical Microbiology.

[7]  C. Nicolaou,et al.  Tigecycline in the treatment of infections from multi-drug resistant gram-negative pathogens. , 2009, The Journal of infection.

[8]  N. Gordon,et al.  A review of clinical and microbiological outcomes following treatment of infections involving multidrug-resistant Acinetobacter baumannii with tigecycline. , 2009, The Journal of antimicrobial chemotherapy.

[9]  D. Nicolau.  Management of complicated infections in the era of antimicrobial resistance: the role of tigecycline. , 2009, Expert opinion on pharmacotherapy.

[10]  M. Falagas,et al.  New antibiotics: optimal use in current clinical practice. , 2009, International journal of antimicrobial agents.

[11]  L. Peterson.  A review of tigecycline--the first glycylcycline. , 2008, International journal of antimicrobial agents.

[12]  L. Martínez-Martínez,et al.  Activity of Tigecycline against Coryneform Bacteria of Clinical Interest and Listeria monocytogenes , 2008, Antimicrobial Agents and Chemotherapy.

[13]  R. Steele,et al.  Tigecycline: A Single Antibiotic for Polymicrobial Infections , 2007, The Pediatric infectious disease journal.

[14]  H. Giamarellou.  Treatment options for multidrug-resistant bacteria , 2006, Expert review of anti-infective therapy.

[15]  Samir N. Patel,et al.  Methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria; approved guideline , 2006 .

[16]  W. Kern,et al.  Corynebacterium jeikeium bacteremia at a tertiary care center , 1991, Infection.

[17]  D. Pegues,et al.  Corynebacterium jeikeium sepsis after 8-methoxypsolaren photopheresis for cutaneous T-cell lymphoma. , 2004, Diagnostic microbiology and infectious disease.

[18]  A. Wald,et al.  Corynebacterium jeikeium bacteremia in bone marrow transplant patients with Hickman catheters , 2001, Bone Marrow Transplantation.

[19]  E. Kuijper,et al.  Corynebacterium CDC group JK (Corynebacterium jeikeium) sepsis in haematological patients: a report of three cases and a systematic literature review. , 1995, Scandinavian journal of infectious diseases.

[20]  J. Fosi-Mbantenkhu,et al.  Predisposition to Corynebacterium jeikeium infection in acute lymphoblastic leukemia: a report of two cases in Trinidad. , 1994, Medical and pediatric oncology.

[21]  G. Bodey,et al.  Infectious complications of indwelling vascular catheters. , 1992, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.