Epilepsy and Neuron Loss in the Hippocampus

Summary: Quantitation of hippocampal neurons was performed in 20 patients with generalized epilepsy. Twelve suffered from partial seizures. The neuronal numbers were compared with the control series of patients without epilepsy. It was established that there were fewer neurons in the hippocampi from patients with epilepsy than from those of controls. The neuron loss was particularly marked in the endfolium (field H3), the granule cells (fascia dentata), and particularly in the caudal (anterior) part of the structure. Frequent, generalized epileptic seizures and long duration of the epileptic disorder influenced the neuron loss. In some parts of the pyramidal band (field H,), the neuron loss appeared at a younger age, which leads one to suspect its particular involvement in the seizure mechanism. The neuron loss was not related to the different types of seizures investigated. The results support the hypothesis of neuron loss as an ongoing process in patients with epilepsy, whatever the type of epilepsy, when tonic‐clonic seizures, as is very common, are present.

[1]  A. M. Dam,et al.  THE DENSITY OF NEURONS IN THE HUMAN HIPPOCAMPUS , 1979 .

[2]  A. Mouritzen Dam,et al.  The density of neurons in the human hippocampus. , 1979, Neuropathology and applied neurobiology.

[3]  B. Meldrum.  Physiological Changes During Prolonged Seizures and Epileptic Brain Damage , 1978, Neuropadiatrie.

[4]  D. Prince,et al.  Cellular and field potential properties of epileptogenic hippocampal slices , 1978, Brain Research.

[5]  S. Gilman,et al.  Neuropathological changes in cerebellar biopsies of epileptic patients , 1978, Annals of neurology.

[6]  P. Crandall,et al.  Evoked response and after-discharge thresholds to electrical stimulation in temporal lobe epileptics. , 1977, Archives of neurology.

[7]  Paul H. Crandall,et al.  Oxygen availability and blood flow in the temporal lobes during spontaneous epileptic seizures in man , 1976, Brain Research.

[8]  F. Andermann,et al.  Temporal lobe epilepsy and perinatal occlusion of the posterior cerebral artery , 1974, Neurology.

[9]  A. Scheibel,et al.  Hippocampal Pathology in Temporal Lobe Epilepsy. A Golgi Survey , 1973 .

[10]  B. Meldrum,et al.  Neuronal loss and gliosis in the hippocampus following repetitive epileptic seizures induced in adolescent baboons by allylglycine. , 1972, Brain research.

[11]  M. Dam.  The density and ultrastructure of the Purkinje cells following diphenylhydantoin treatment in animals and man. , 1972, Acta neurologica Scandinavica. Supplementum.

[12]  T. Mclardy.  Ammonshorn Pathology and Epileptic Dyscontrol , 1969, Nature.

[13]  F. Seitelberger.  General neuropathology of degenerative processes of the nervous system. , 1969, Neurosciences research.

[14]  Milo Keynes,et al.  Biological Factors in Temporal Lobe Epilepsy , 1967 .

[15]  H. Haug.  Probleme und Methoden der Strukturzählung im Schnittpräparat , 1967 .

[16]  E. Serafetinides,et al.  ETIOLOGY AND PATHOGENESIS OF TEMPORAL LOBE EPILEPSY. , 1964, Archives of neurology.

[17]  J. Green,et al.  SURGERY OF EPILEPTOGENIC LESIONS OF THE TEMPORAL LOBE. , 1964, Archives of neurology.

[18]  J. Peiffer.  Morphologische Aspekte der Epilepsien , 1963 .

[19]  W. Scholz.  The Contribution of Patho‐Anatomical Research to the Problem of Epilepsy , 1959 .

[20]  H. Gastaut,et al.  A Correlation of Clinical, Electroencephalographic and Anatomical Findings in Nine Autopsied Cases of “Temporal Lobe Epilepsy” , 1959 .

[21]  J. Corsellis.  The incidence of Ammon's horn sclerosis. , 1957, Brain : a journal of neurology.

[22]  W PENFIELD,et al.  Epileptogenic lesions. , 1956, Acta neurologica et psychiatrica Belgica.

[23]  R. Lindenberg.  COMPRESSION OF BRAIN ARTERIES AS PATHOGENETIC FACTOR FOR TISSUE NECROSES AND THEIR AREAS , 1955, Journal of neuropathology and experimental neurology.

[24]  D. Hill,et al.  Treatment of temporal-lobe epilepsy by temporal lobectomy; a survey of findings and results. , 1955, Lancet.

[25]  R.N.DeJ..  Epilepsy and the Functional Anatomy of the Human Brain , 1954, Neurology.

[26]  W. Penfield,et al.  Incisural sclerosis and temporal lobe seizures produced by hippocampal herniation at birth. , 1953, A.M.A. archives of neurology and psychiatry.

[27]  Willibald Scholz.  Die Krampfschädigungen des Gehirns , 1951 .

[28]  C. Villavicencio.  [Surgical treatment of psychomotor epilepsy]. , 1951, Neurocirugia.

[29]  F. Gibbs,et al.  Psychomotor epilepsy. , 1948, Archives of neurology and psychiatry.

[30]  M. Abercrombie.  Estimation of nuclear population from microtome sections , 1946, The Anatomical record.

[31]  Die Topik der Ammonshornschädigung , 1930 .

[32]  W. Spielmeyer.  Über örtliche Vulnerabilität , 1929 .