Weightlifting and the actomyosin cycle

How does a human lift a weight? Can we relate the dynamics of the lift to the molecular actin–myosin interactions responsible for muscle contraction? We address these questions with bench press experiments that we analyse with a theoretical model, based on the sliding filament theory. The agreement is fair, and we discuss its possible extension to medical diagnostics.

[1]  R. T. Tregear,et al.  Movement and force produced by a single myosin head , 1995, Nature.

[2]  H. Huxley.  Fifty years of muscle and the sliding filament hypothesis. , 2004, European journal of biochemistry.

[3]  H. Lodish.  Molecular Cell Biology , 1986 .

[4]  D. Wilkie.  The relation between force and velocity in human muscle , 1949, The Journal of physiology.

[5]  I. Gryczynski,et al.  Cross-bridge duty cycle in isometric contraction of skeletal myofibrils. , 2008, Biochemistry.

[6]  H. Huxley.  X-ray analysis and the problem of muscle , 1953, Proceedings of the Royal Society of London. Series B - Biological Sciences.

[7]  Alf Månsson,et al.  Actomyosin-ADP states, interhead cooperativity, and the force-velocity relation of skeletal muscle. , 2010, Biophysical journal.

[8]  R. Cooke,et al.  Orientation of spin labels attached to cross-bridges in contracting muscle fibres , 1982, Nature.

[9]  A. Huxley.  Muscle structure and theories of contraction. , 1957, Progress in biophysics and biophysical chemistry.

[10]  O. Schmitt.  The heat of shortening and the dynamic constants of muscle , 2017 .

[11]  A. Huxley.  Muscular contraction. Review lecture , 1974 .

[12]  J. Sellers,et al.  Direct observation of the myosin-V power stroke and its reversal , 2010, Nature Structural &Molecular Biology.

[13]  Aristotle,et al.  Aristotle's De Motu Animalium , 1980 .

[14]  James J. Feng,et al.  Mathematical simulation of muscle cross-bridge cycle and force-velocity relationship. , 2006, Biophysical journal.

[15]  D. Needham.  Machina Carnis: The Biochemistry of Muscular Contraction in its Historical Development , 1971 .

[16]  Kenneth C. Holmes,et al.  Introduction: one contribution of 14 to a discussion meeting issue 'Myosin, muscle and motility' , 2004 .

[17]  Thomas A. McMahon,et al.  Muscles, Reflexes, and Locomotion , 1984 .

[18]  C. Clanet,et al.  Capillary muscle , 2015, Proceedings of the National Academy of Sciences.

[19]  Matthias Rief,et al.  Myosin-V is a mechanical ratchet. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[20]  J. Spudich,et al.  Single myosin molecule mechanics: piconewton forces and nanometre steps , 1994, Nature.

[21]  B. Colombini,et al.  Characterization of actomyosin bond properties in intact skeletal muscle by force spectroscopy , 2007, Proceedings of the National Academy of Sciences.

[22]  Martha Craven Nussbaum,et al.  Aristotle's De Motu Animalium. , 1980 .

[23]  J. Telleria.  [Mechanism of muscular contraction]. , 1951, Medicina.

[24]  Giovanni Alfonso Borelli,et al.  De motu animalium , 1967 .

[25]  A kinetic theory of striated muscle contraction. , 1971, Biorheology.

[26]  Michael Grüninger,et al.  Introduction , 2002, CACM.