Icariin reduces α-synuclein over-expression by promoting α-synuclein degradation

[1]  Ru-yi Zhang,et al.  Icariin Decreases the Expression of APP and BACE-1 and Reduces the β-amyloid Burden in an APP Transgenic Mouse Model of Alzheimer's Disease , 2014, International journal of biological sciences.

[2]  Wenlong Lv,et al.  Icaritin Synergistically Enhances the Radiosensitivity of 4T1 Breast Cancer Cells , 2013, PloS one.

[3]  P. Wipf,et al.  Chemical induction of Hsp70 reduces α-synuclein aggregation in neuroglioma cells. , 2013, ACS chemical biology.

[4]  M. Xilouri,et al.  Alpha-synuclein and Protein Degradation Systems: a Reciprocal Relationship , 2013, Molecular Neurobiology.

[5]  S. Chen,et al.  Dysfunction of two lysosome degradation pathways of α-synuclein in Parkinson’s disease: potential therapeutic targets? , 2012, Neuroscience Bulletin.

[6]  L. Stefanis.  α-Synuclein in Parkinson's disease. , 2012, Cold Spring Harbor perspectives in medicine.

[7]  H. Hampel,et al.  Biomarker candidates of neurodegeneration in Parkinson’s disease for the evaluation of disease-modifying therapeutics , 2011, Journal of Neural Transmission.

[8]  B. Hyman,et al.  Heat‐shock protein 70 modulates toxic extracellular α‐synuclein oligomers and rescues trans‐synaptic toxicity , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[9]  Karen A. Lewis,et al.  Abnormal neurites containing C-terminally truncated alpha-synuclein are present in Alzheimer's disease without conventional Lewy body pathology. , 2010, The American journal of pathology.

[10]  C. Tohda,et al.  Icariin improves memory impairment in Alzheimer's disease model mice (5xFAD) and attenuates amyloid β‐induced neurite atrophy , 2010, Phytotherapy research : PTR.

[11]  T. Renda,et al.  Immunolocalization of alpha-synuclein in the rat spinal cord by two novel monoclonal antibodies , 2009, Neuroscience.

[12]  Hui Zheng,et al.  Lack of α-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease , 2007, Molecular Neurodegeneration.

[13]  P. Chan,et al.  Extensive nuclear localization of α-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody , 2007, Neuroscience.

[14]  D. Moore.  Parkin: a multifaceted ubiquitin ligase. , 2006, Biochemical Society transactions.

[15]  K. M. Chen,et al.  Icariin, a flavonoid from the herb Epimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells. , 2005, Die Pharmazie.

[16]  Wei He,et al.  A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and β-amyloid plaques in a mouse model of Alzheimer's disease , 2003, Neurobiology of Disease.

[17]  Kaori Nishikawa,et al.  Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. , 2003, Human molecular genetics.

[18]  P. Lockhart,et al.  Parkin Protects against the Toxicity Associated with Mutant α-Synuclein Proteasome Dysfunction Selectively Affects Catecholaminergic Neurons , 2002, Neuron.

[19]  K. McNaught,et al.  Proteasomal function is impaired in substantia nigra in Parkinson's disease , 2001, Neuroscience Letters.

[20]  A. Ciechanover,et al.  The ubiquitin system , 2000, Nature Medicine.

[21]  A. Iwai.  Properties of NACP/α-synuclein and its role in Alzheimer’s disease , 2000 .

[22]  R. Hamilton,et al.  Lewy Bodies in Alzheimer's Disease: A Neuropathological Review of 145 Cases Using α‐Synuclein Immunohistochemistry , 2000, Brain pathology.

[23]  Shinsei Minoshima,et al.  Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase , 2000, Nature Genetics.

[24]  M. Vila,et al.  α‐Synuclein Up‐Regulation in Substantia Nigra Dopaminergic Neurons Following Administration of the Parkinsonian Toxin MPTP , 2000, Journal of neurochemistry.

[25]  B. Sommer,et al.  Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[26]  E. Masliah,et al.  Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[27]  J. Dorszewska,et al.  [Alpha-synuclein in Parkinson's disease]. , 2014, Przeglad lekarski.

[28]  Ru-yi Zhang,et al.  Tetrahydroxystilbene glucoside antagonizes age-related α-synuclein overexpression in the hippocampus of APP transgenic mouse model of Alzheimer's disease. , 2013, Restorative neurology and neuroscience.

[29]  M. Ciotti,et al.  Spontaneous aggregation and altered intracellular distribution of endogenous alpha-synuclein during neuronal apoptosis. , 2008, Journal of Alzheimer's disease : JAD.

[30]  A. Ciechanover,et al.  Basic Medical Research Award. The ubiquitin system. , 2000, Nature medicine.

[31]  A. Iwai.  Properties of NACP/alpha-synuclein and its role in Alzheimer's disease. , 2000, Biochimica et biophysica acta.

[32]  Paul Nurse,et al.  Basic Medical Research Award , 1998 .