Levetiracetam in the treatment of paroxysmal kinesiogenic choreoathetosis

Anticonvulsants are frequently used in the treatment of paroxysmal kinesiogenic choreoathetosis (PKC). Although they are often extremely effective in eliminating paroxysmal movements, short‐ and long‐term side‐effects may limit their use in young patients. Levetiracetam (Keppra), a novel antiepileptic drug approved for the treatment of partial seizures is well tolerated in patients with epilepsy. We report on the use of levetiracetam in the treatment of PKC. Levetiracetam was effective in eliminating paroxysmal events and should be considered as an alternative to standard antiepileptic medications in this disorder. © 2002 Movement Disorder Society

[1]  H. Przuntek,et al.  Therapeutic aspects of kinesiogenic paroxysmal choreoathetosis and familial paroxysmal choreoathetosis of the Mount and Reback type , 2004, Journal of Neurology.

[2]  S. Fahn,et al.  A pilot tolerability and efficacy study of levetiracetam in patients with chronic myoclonus , 2001, Neurology.

[3]  K. Bhatia,et al.  Familial (Idiopathic) Paroxysmal Dyskinesias: An Update , 2001, Seminars in neurology.

[4]  D. Margineanu,et al.  Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs. , 2000, Pharmacological research.

[5]  G. Plosker,et al.  Levetiracetam. A review of its adjunctive use in the management of partial onset seizures. , 2000, Drugs.

[6]  K. Jain.  An assessment of levetiracetam as an anti-epileptic drug , 2000, Expert opinion on investigational drugs.

[7]  F. Dubeau,et al.  Exquisite sensitivity of paroxysmal kinesigenic choreoathetosis to carbamazepine , 1996, Neurology.

[8]  J. Hénichart,et al.  The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes. , 1995, European journal of pharmacology.

[9]  M. Kato,et al.  Paroxysmal Kinesigenic Choreoathetosis: Report of a Case Relieved by Carbamazepine , 1969 .

[10]  A. Kertesz.  Paroxysmal kinesigenic choreoathetosis , 1967, Neurology.

[11]  L. Mount,et al.  FAMILIAL PAROXYSMAL CHOREOATHETOSIS: Preliminary Report on a Hitherto Undescribed Clinical Syndrome , 1940 .