Primary lymphoma of the central nervous system—a diagnostic challenge

Primary lymphoma of the central nervous system is a distinct diffuse large B‐cell lymphoma confined to the nervous system. Whereas classical cases can be classified easily, differential diagnosis can be a challenge in particular in patients who had received treatment prior to biopsy. In the differential diagnosis, other tumours and inflammatory diseases of autoimmune and infectious aetiology need to be considered. Copyright © 2013 John Wiley & Sons, Ltd.

[1]  W. Klapper,et al.  Differenzialdiagnose lymphoider Infiltrate im Zentralnervensystem , 2013, Der Pathologe.

[2]  J. Southern,et al.  Pathology of Central Nervous System Posttransplant Lymphoproliferative Disorders: Lessons from Pediatric Autopsies , 2013, Pediatric and Developmental Pathology.

[3]  W. Schmiegel,et al.  MicroRNAs in cerebrospinal fluid as biomarker for disease course monitoring in primary central nervous system lymphoma , 2012, Journal of Neuro-Oncology.

[4]  G. Hunder,et al.  Primary central nervous system vasculitis: pathology and mechanisms , 2012, Acta Neuropathologica.

[5]  G. Reifenberger,et al.  Inflammatory Demyelinating Brain Lesions Heralding Primary CNS Lymphoma , 2012, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[6]  W. Klapper,et al.  Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma , 2011, Leukemia.

[7]  T. Gasser,et al.  Three cases of CLIPPERS: a serial clinical, laboratory and MRI follow-up study , 2011, Journal of Neurology.

[8]  C. Doglioni,et al.  Central nervous system marginal zone B-cell lymphoma associated with Chlamydophila psittaci infection. , 2011, Human pathology.

[9]  R. Gold,et al.  Identification of microRNAs in the cerebrospinal fluid as marker for primary diffuse large B-cell lymphoma of the central nervous system. , 2011, Blood.

[10]  A. Brunn,et al.  Diagnosis of leptomeningeal disease in diffuse large B‐cell lymphomas of the central nervous system by flow cytometry and cytopathology , 2010, European journal of haematology.

[11]  C. Doglioni,et al.  Perivascular expression of CXCL9 and CXCL12 in primary central nervous system lymphoma: T‐cell infiltration and positioning of malignant B cells , 2010, International journal of cancer.

[12]  L. Gordon,et al.  Post-Transplantation Lymphoproliferative Disorders: Diagnosis, Prognosis, and Current Approaches to Therapy , 2010, Current oncology reports.

[13]  M. Lopes,et al.  IgG4-related meningeal disease: clinico-pathological features and proposal for diagnostic criteria , 2010, Acta Neuropathologica.

[14]  B. Weinshenker,et al.  Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). , 2010, Brain : a journal of neurology.

[15]  A. Straube,et al.  Cerebral angiitis in four patients with chronic GVHD , 2010, Bone Marrow Transplantation.

[16]  P. Aridon,et al.  Progressive necrotic encephalopathy following tacrolimus therapy for liver transplantation , 2009, Neurological Sciences.

[17]  Kai Fu,et al.  A New Immunostain Algorithm Classifies Diffuse Large B-Cell Lymphoma into Molecular Subtypes with High Accuracy , 2009, Clinical Cancer Research.

[18]  D. Hellmann,et al.  Primary angiitis of the central nervous system. , 2009, Archives of neurology.

[19]  E. Thiel,et al.  Meningeal dissemination in primary CNS lymphoma , 2008, Neurology.

[20]  R. Kalnins,et al.  Prolonged interval between sentinel pseudotumoral demyelination and development of primary CNS lymphoma , 2007, Journal of Clinical Neuroscience.

[21]  J. Blay,et al.  Reactive perivascular T‐cell infiltrate predicts survival in primary central nervous system B‐cell lymphomas , 2007, British journal of haematology.

[22]  E. Campo,et al.  Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[23]  Andrew Lister,et al.  Immunohistochemical prognostic markers in diffuse large B-cell lymphoma: validation of tissue microarray as a prerequisite for broad clinical applications--a study from the Lunenburg Lymphoma Biomarker Consortium. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[24]  H. Hsu,et al.  Comparison of the expression and prognostic significance of differentiation markers between diffuse large B-cell lymphoma of central nervous system origin and peripheral nodal origin. , 2006, Clinical cancer research : an official journal of the American Association for Cancer Research.

[25]  L. Staudt,et al.  Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction. , 2005, Blood.

[26]  J. Armitage,et al.  Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[27]  Y. Kasamon,et al.  AIDS-related primary central nervous system lymphoma. , 2005, Hematology/oncology clinics of North America.

[28]  E. Schuuring,et al.  High numbers of tumour‐infiltrating activated cytotoxic T lymphocytes, and frequent loss of HLA class I and II expression, are features of aggressive B cell lymphomas of the brain and testis , 2005, The Journal of pathology.

[29]  G. Reifenberger,et al.  Absence of immunoglobulin class switch in primary lymphomas of the central nervous system. , 2005, The American journal of pathology.

[30]  J. Blay,et al.  Primary CNS lymphoma of T-cell origin: a descriptive analysis from the international primary CNS lymphoma collaborative group. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[31]  W. Wilson,et al.  High incidence of occult leptomeningeal disease detected by flow cytometry in newly diagnosed aggressive B-cell lymphomas at risk for central nervous system involvement: the role of flow cytometry versus cytology. , 2005, Blood.

[32]  Myung-Hwan Kim,et al.  Autoimmune Chronic Pancreatitis , 2004, American Journal of Gastroenterology.

[33]  M. Deckert,et al.  Concomitant manifestation of primary CNS lymphoma and Toxoplasma encephalitis in a patient with AIDS , 2004, Journal of Neurology.

[34]  M. Boiocchi,et al.  Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas. , 2004, Journal of the National Cancer Institute.

[35]  Masatoshi Watanabe,et al.  Intravascular large B‐cell lymphoma presenting with mass lesions in the central nervous system: A report of five cases , 2004, Pathology international.

[36]  S. Kawa,et al.  Autoimmune pancreatitis and bile duct lesions , 2003, Journal of Gastroenterology.

[37]  B. Poiesz,et al.  Primary Central Nervous System Cytotoxic/Suppressor T‐Cell Lymphoma: Report of a Unique Case and Review of the Literature , 2003, The American journal of surgical pathology.

[38]  N. Harris,et al.  BCL-6 expression predicts improved survival in patients with primary central nervous system lymphoma. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[39]  J. Blay,et al.  Prognostic scoring system for primary CNS lymphomas: the International Extranodal Lymphoma Study Group experience. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[40]  L. Deangelis,et al.  Primary CNS lymphoma , 2002, Neurology.

[41]  E. Thiel,et al.  CSF evaluation in primary CNS lymphoma patients by PCR of the CDR III IgH genes , 2002, Neurology.

[42]  Ash A. Alizadeh,et al.  Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling , 2000, Nature.

[43]  G. Reifenberger,et al.  Primary central nervous system lymphomas are derived from germinal-center B cells and show a preferential usage of the V4-34 gene segment. , 1999, The American journal of pathology.

[44]  R. Simon,et al.  Chromosomal imbalances in primary lymphomas of the central nervous system. , 1999, The American journal of pathology.

[45]  L. Larocca,et al.  The molecular and phenotypic profile of primary central nervous system lymphoma identifies distinct categories of the disease and is consistent with histogenetic derivation from germinal center-related B cells. , 1998, Blood.

[46]  D. Louis,et al.  Sentinel lesions of primary CNS lymphoma. , 1996, Journal of neurology, neurosurgery, and psychiatry.

[47]  L. Calabrese,et al.  Limitations of invasive modalities in the diagnosis of primary angiitis of the central nervous system. , 1995, The Journal of rheumatology.

[48]  J. Parisi,et al.  The role of biopsy in vasculitis of the central nervous system. , 1994, Seminars in neurology.

[49]  M. Deckert,et al.  Toxoplasma encephalitis of immunocompetent and nude mice: immunohistochemical characterisation of Toxoplasma antigen, infiltrates and major histocompatibility complex gene products , 1991, Journal of Neuroimmunology.

[50]  L. Calabrese,et al.  Primary Angiitis of the Central Nervous System: REPORT OF 8 NEW CASES, REVIEW OF THE LITERATURE, AND PROPOSAL FOR DIAGNOSTIC CRITERIA , 1988, Medicine.

[51]  P. Kleihues,et al.  The Use of the Monoclonal Antibody Ki-67 in the Identification of Proliferating Cells: Application to Surgical Neuropathology , 1986, The American journal of surgical pathology.

[52]  J. Pumar,et al.  [Primary lymphoma of the central nervous system in immunocompetent patients: neuroimaging features]. , 2012, Revista de neurología (Ed. impresa).

[53]  T. Sano,et al.  Pituitary and stalk lesions (infundibulo-hypophysitis) associated with immunoglobulin G4-related systemic disease: an emerging clinical entity. , 2009, Endocrine journal.

[54]  L. Deangelis,et al.  Bcl‐6 predicts improved prognosis in primary central nervous system lymphoma , 2008, Cancer.

[55]  E. Thiel,et al.  The diagnostic value of cerebrospinal fluid pleocytosis and protein in the detection of lymphomatous meningitis in primary central nervous system lymphomas. , 2006, Haematologica.

[56]  K. Hoang-Xuan,et al.  A uniform activated B-cell-like immunophenotype might explain the poor prognosis of primary central nervous system lymphomas: analysis of 83 cases. , 2006, Blood.

[57]  G. Reifenberger,et al.  Determination of the proliferative potential of human brain tumors using the monoclonal antibody Ki-67 , 2004, Journal of Cancer Research and Clinical Oncology.

[58]  L. Staudt,et al.  Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. , 2004, Blood.

[59]  E. Rodríguez.  [Malignant lymphomas]. , 1985, Revista de enfermeria.